Administrative Core
行政核心
基本信息
- 批准号:10270973
- 负责人:
- 金额:$ 35.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-05-13 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdvisory CommitteesApplications GrantsAreaBig DataBioinformaticsCOVID-19 testingCareer MobilityCell SeparationCenter for Translational Science ActivitiesCenters of Research ExcellenceClinicClinicalCollaborationsCollectionCore FacilityData AnalysesDiseaseEnsureEpigenetic ProcessEvaluationEventExtramural ActivitiesFlow CytometryFosteringFundingGoalsGraduation RatesGrantGrant ReviewGroomingHandHealthHealth SciencesHistologyHumanImageImage CytometryImmune responseIndividualInflammatoryInfrastructureJournalsMentorsMicrobeNatureNorth DakotaOutcomePeripheralPhaseProductivityProgram DevelopmentPublicationsResearchResearch InfrastructureResearch PersonnelResearch SupportResourcesSamplingSeriesServicesSupport GroupsTherapeuticUnited States National Institutes of HealthWorkbiomedical scientistcareercareer developmenteducation resourcesgut dysbiosishigh throughput analysishost-microbe interactionsimmunoregulationmedical schoolsmeetingsmembermicrobial communitynovelpandemic diseasepathogenpathogenic bacteriapathogenic virusprogramsrecruitservice providerssuccesssymposium
项目摘要
Summary
The goal of Administrative Core in Phase 2 is to continue centralizing and managing resources necessary to
enhance the success of the COBRE on Host-pathogen Interactions (HPI). Building on the success of Phase 1,
this Core will provide support to investigators focused on determining the mechanisms underlying immune
modulations in the host upon interaction with various microbes to identify possible treatments for devastating
inflammatory diseases. Specifically, the concerted effort will focus on (1) expanding the research enterprise of
this center by supporting and recruiting junior investigators working on host-microbe interactions that are central
to human health and diseases; (2) facilitating productive scientific interactions by organizing networking
opportunities through annual symposium and seminar series ; (3) providing an individualized and tailored
mentoring program for each investigator; 4) providing oversight and support for mentoring programs through
Internal and External Advisory Committees with regular meetings; 5) raising the national profile of the group by
providing cutting edge infrastructural support; 6) establishing a new Computational Data Analysis Core facility to
provide cutting-edge bioinformatics analytical and interpretative support for the group; 6) providing administrative
support to the existing Cores (Histology, Imaging and Flow Cytometry; and 7) fostering collaboration between
the other North Dakota COBRE, INBRE and CTR DaCCoTA grant supported groups and between individuals in
the respective groups. Successful completion of these goals in Phase 2 of our COBRE will elevate this center to
a nationally recognized level with a group dedicated to understanding various aspects of host-microbe
interactions in human health and disease. With the recent funding of a Phase 2 Epigenetics COBRE and a Phase
I Clinical Translational Research Center DaCCoTA, our HPI COBRE Phase 2 has an unprecedented opportunity
at hand to execute high-quality, cutting edge research of immense therapeutic and clinical potential.
总结
第二阶段行政核心的目标是继续集中和管理必要的资源,
增强COBRE在宿主-病原体相互作用(HPI)方面的成功。在第一阶段成功的基础上,
该核心将为致力于确定免疫机制的研究人员提供支持
在与各种微生物相互作用后,宿主中的调节,以确定可能的治疗破坏性
炎症性疾病。具体而言,协调一致的努力将集中在(1)扩大研究企业,
该中心通过支持和招募初级研究人员从事宿主-微生物相互作用,
(2)通过组织网络,促进富有成效的科学互动
通过年度研讨会和系列研讨会提供机会;(3)提供个性化和量身定制的
为每个调查员提供指导计划; 4)通过以下方式为指导计划提供监督和支持
内部和外部咨询委员会,定期举行会议; 5)通过以下方式提高集团的国家形象:
提供最先进的基础设施支持; 6)建立新的计算数据分析核心设施,
为小组提供尖端的生物信息学分析和解释支持; 6)提供行政管理
支持现有核心(组织学、成像和流式细胞术); 7)促进
其他北达科他州COBRE,INBRE和CTR DaCCoTA赠款支持团体和个人之间,
各自的群体。在我们的COBRE第2阶段成功完成这些目标将使该中心提升到
一个国家认可的水平,一个致力于了解宿主微生物各个方面的小组
人类健康和疾病的相互作用。随着最近对第二阶段表观遗传学COBRE和第三阶段的资助,
I临床转化研究中心DaCCoTA,我们的HPI COBRE 2期有一个前所未有的机会
随时准备执行具有巨大治疗和临床潜力的高质量尖端研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Colin K Combs其他文献
Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Aβ1-40
- DOI:
10.1186/1742-2094-7-22 - 发表时间:
2010-01-01 - 期刊:
- 影响因子:10.100
- 作者:
Cindy M Sondag;Colin K Combs - 通讯作者:
Colin K Combs
Colin K Combs的其他文献
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{{ truncateString('Colin K Combs', 18)}}的其他基金
Communicating Lung Dysfunction to the Brain in Alzheimer's Disease
阿尔茨海默氏病将肺功能障碍传达给大脑
- 批准号:
10711004 - 财政年份:2023
- 资助金额:
$ 35.76万 - 项目类别:
Impact of sex differences on molecular determinants of AD risk and responsiveness to treatment
性别差异对 AD 风险分子决定因素和治疗反应的影响
- 批准号:
10482427 - 财政年份:2021
- 资助金额:
$ 35.76万 - 项目类别:
Oral Cavity and Brain Cross-talk in Alzheimer's Disease
阿尔茨海默病中的口腔和大脑交互作用
- 批准号:
10231824 - 财政年份:2021
- 资助金额:
$ 35.76万 - 项目类别:
Impact of sex differences on molecular determinants of AD risk and responsiveness to treatment
性别差异对 AD 风险分子决定因素和治疗反应的影响
- 批准号:
10295254 - 财政年份:2021
- 资助金额:
$ 35.76万 - 项目类别:
Impact of sex differences on molecular determinants of AD risk and responsiveness to treatment
性别差异对 AD 风险分子决定因素和治疗反应的影响
- 批准号:
10652594 - 财政年份:2021
- 资助金额:
$ 35.76万 - 项目类别:
Communicating Intestinal Inflammation to the Brain in Alzheimer's Disease
阿尔茨海默氏病中肠道炎症与大脑的沟通
- 批准号:
10472821 - 财政年份:2020
- 资助金额:
$ 35.76万 - 项目类别:
Long noncoding RNAs interact with miRNAs to regulate inflammatory response
长非编码 RNA 与 miRNA 相互作用调节炎症反应
- 批准号:
10216960 - 财政年份:2018
- 资助金额:
$ 35.76万 - 项目类别:
Mechanisms of exposure-induced tissue functional and pathological changes in a mouse model of Alzheimer's Disease
阿尔茨海默病小鼠模型暴露引起的组织功能和病理变化的机制
- 批准号:
9908035 - 财政年份:2017
- 资助金额:
$ 35.76万 - 项目类别:
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