Histology Core

组织学核心

• 批准号: 10270975
• 负责人: Colin K Combs
• 金额: $ 14.28万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-13 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10270975
• 关键词: Applications Grants; Biomedical Research; Businesses; Centers of Research Excellence; Cities; Communities; Core Facility; Coupled; Drops; Ensure; Equipment; Experimental Designs; Fee-for-Service Plans; Fees; Floor; Growth; Health Sciences; Histological Techniques; Histology; Human; Image; Image Analysis; Infrastructure; Institution; Instruction; Investments; Maintenance; Morphology; North Dakota; Nutritional Study; Outcome; Pathologist; Phase; Preparation; Productivity; Publications; Recommendation; Research; Research Personnel; Resolution; Resources; Safety; Sampling; Services; Slide; Stains; Structure; Students; Suggestion; Techniques; Time; Tissue Banks; Tissue Fixation; Tissue Sample; Tissues; Training; United States National Institutes of Health; Universities; Veterinarians; Vision; analytical tool; base; cost; detection method; fluorescence imaging; improved; instrument; instrumentation; medical schools; meetings; member; pathogen; programs; response; sample fixation; tissue preparation; tribal college; undergraduate student; whole slide imaging

Summary The Histology Core at UND was established to improve the infrastructure supporting our successful implementation of the Phase 1 Center for Excellence in Host Pathogen Interactions COBRE at the University of North Dakota School of Medicine and Health Sciences. The Core was developed to provide high quality instrumentation, tissue preparation, staining, image analysis services, and training in a wide spectrum of fundamental and advanced histological techniques to COBRE research investigators. The Core also provides access and support to non-COBRE investigators within and outside the UND SMHS, as well as those from institutions adjoining (USDA-Grand Forks Human Nutrition Research Center) and in neighboring cities (North Dakota State University, North Dakota primarily undergraduate institutions and tribal colleges). The Core remains essential for successful growth of the host pathogen interaction enterprise at UND and completing al four of the projects proposed in this Phase 2 renewal application. The Core evolved from being a primarily shared equipment facility with provided user training to now a complete drop off service facility for users across the UND campus. Multiple tissue sectioning and staining services coupled with whole slide brightfield or fluorescent imaging and image quantitation have made the Core invaluable to growth of the research enterprise at UND. In Phase 2, the Core will continue to assist COBRE team members and the broader UND/ND research community with experimental design specifically with regards to application-specific sample preparation techniques, identifying appropriate analytical tools available, resolution restrictions, and quantitative morphological techniques. The Core will also provide service, training, and instruction to COBRE and other users in all aspects of instrument use, safety, tissue sample preparation, and aid with trouble shooting all aspects of tissue preparation and analysis. Finally, the Core will implement a business plan that includes strategies to continue expanding the user base and provide fee-for-service assistance in all aspects of histo- and immunochemical detection methods and analyses, thus paving a way to long-term sustainability of the Core.

总结 UND组织学核心的建立是为了改善基础设施，支持我们成功的 在该大学实施宿主病原体相互作用COBRE卓越中心的第一阶段 北达科他州医学与健康科学学院的教授。核心是为了提供高质量的 仪器，组织制备，染色，图像分析服务，以及广泛的 为COBRE研究人员提供基础和先进的组织学技术。核心还提供 访问和支持非COBRE调查员内部和外部的UND SMHS，以及那些从 毗邻（美国农业部-大福克斯人类营养研究中心）和邻近城市（北 达科他州立大学，北达科他州主要是本科院校和部落学院）。核心 对于UND宿主病原体相互作用企业的成功发展和完成所有 第二阶段更新申请中提出的四个项目。核心从最初的 共享设备设施，提供用户培训，现在是一个完整的下车服务设施，为用户提供 UND校园多种组织切片和染色服务，以及全载玻片明场或 荧光成像和图像定量使核心对研究的发展非常宝贵 企业在UND在第二阶段，核心将继续协助COBRE团队成员和更广泛的 UND/ND研究社区，专门针对特定应用样本进行实验设计 制备技术，确定可用的适当分析工具，分辨率限制和定量 形态学技术核心还将为COBRE和其他机构提供服务、培训和指导。 用户在仪器使用、安全性、组织样本制备的各个方面， 组织制备和分析方面。最后，核心将实施一项业务计划，其中包括 继续扩大用户基础和在历史学各方面提供收费服务援助的战略， 以及免疫化学检测方法和分析，从而为长期可持续发展铺平了道路。 核心