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Identification of Novel Agents to Treat PTSD using Clinical Data

Identification of Novel Agents to Treat PTSD using Clinical Data
利用临床数据鉴定治疗 PTSD 的新药
批准号:
10579848
负责人:
Jaimie L. Gradus
金额:
$53.98万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-05-01 至 2025-02-28

项目摘要

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中文摘要
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项目总结
英文摘要
PROJECT SUMMARY This study will leverage large-scale clinical data from the Department of Veterans Affairs (VA) to identify existing pharmaceutical agents commonly prescribed for a multitude of indications that are incidentally associated with improvements in post-traumatic stress disorder (PTSD) symptoms. Through prior efforts, a data source containing almost 20 years of treatment data on all (over one million) VA users diagnosed with PTSD between October 1999 and February 2018 has been constructed, including a complete historical record of their evidence-based medication and psychotherapy receipt within the VA healthcare system. Importantly, the team has also amassed symptom-level patient-reported PTSD outcome data for hundreds of thousands of these patients. The existing data is a powerful resource with which the research team proposes to explore the following specific aims: (1) identify off-label pharmaceutical agents associated with improvements in PTSD symptoms over time; (2) further evaluate the clinical effectiveness of newly-identified off-label pharmaceutical agents for improvement in PTSD symptoms using rigorous causal methods; and (3) identify common adverse events related to off-label pharmaceutical agents associated with improvements in PTSD symptoms in this complex, psychiatrically and medically ill population The proposed project will identify agents that may merit further rigorous clinical evaluation for psychiatric benefit. New therapeutic targets may be identified that will lead to greater treatment options or specific treatments. Further, identification of off-label medications that improve or have contraindicated effects for psychiatric populations will provide critical guidance to practicing clinicians.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Comparative Effectiveness of Direct-Acting Antivirals for Posttraumatic Stress Disorder in Veterans Affairs Patients With Hepatitis C Virus Infection.
直接作用抗病毒药物治疗丙型肝炎病毒感染退伍军人事务部患者创伤后应激障碍的比较疗效。
DOI: 10.1093/aje/kwac104
发表时间: 2022
期刊: American journal of epidemiology
影响因子: 5
作者: [Shiner,Brian, Huybrechts,Krista, Gui,Jiang, Rozema,Luke, Forehand,Jenna, Watts,BradleyV, Jiang,Tammy, Hoyt,JessicaE, Esteves,Jack, Schnurr,PaulaP, Ray,Kristen, Gradus,JaimieL]
通讯作者: Gradus,JaimieL
DOI: 10.1016/j.biopsych.2021.10.008
发表时间: 2022-04-01
期刊: Biological psychiatry
影响因子: 10.6
作者: [Shiner B, Forehand JA, Rozema L, Kulldorff M, Watts BV, Trefethen M, Jiang T, Huybrechts KF, Schnurr PP, Vincenti M, Gui J, Gradus JL]
通讯作者: Gradus JL
Safety of Glecaprevir/Pibrentasvir for hepatitis C in patients with posttraumatic stress disorder: A post-marketing surveillance study.
Glecaprevir/Pibrentasvir 对于创伤后应激障碍患者治疗丙型肝炎的安全性:一项上市后监测研究。
DOI: 10.1016/j.genhosppsych.2023.06.012
发表时间: 2023
期刊: General hospital psychiatry
影响因子: 7
作者: [Shiner,Brian, Park,JennaA, Rozema,Luke, Hoyt,JessicaE, Watts,BradleyV, Gradus,JaimieL]
通讯作者: Gradus,JaimieL
Identifying the longitudinal outcomes of suicide loss in a population-based cohort
  • 批准号:
    10716673
  • 项目类别:
  • 资助金额:
    $73.83万
  • 财政年份:
    2023
  • 负责人:
    Jaimie L. Gradus
  • 依托单位:
Identifying Cardiotoxic Manifestations of Posttraumatic Psychopathology: A Population-based Longitudinal Investigation
Identifying Cardiotoxic Manifestations of Posttraumatic Psychopathology: A Population-based Longitudinal Investigation
Identification of Novel Agents to Treat PTSD using Clinical Data
  • 批准号:
    10371100
  • 项目类别:
  • 资助金额:
    $55.58万
  • 财政年份:
    2020
  • 负责人:
    Jaimie L. Gradus
  • 依托单位:
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