Identifying the longitudinal outcomes of suicide loss in a population-based cohort
确定基于人群的队列中自杀损失的纵向结果
基本信息
- 批准号:10716673
- 负责人:
- 金额:$ 73.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-06 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:AccidentsAddressAdverse eventBig DataCaringCessation of lifeChildComputerized Medical RecordDataData SourcesDenmarkDiagnosticDiseaseDistressEpidemiologyEventExposure toFamilyFirst Degree RelativeFoundationsFriendsFundingFutureGeneral PopulationGoalsGovernmentHealthHealthcareHealthcare SystemsIndividualInsuranceInternational Classification of Disease CodesInterventionKnowledgeLinkLiteratureMedicalMental HealthMethodsNational Institute of Mental HealthOutcomePatternPersonsPolicy MakerPopulationPreventionPsychiatric epidemiologyPublic HealthPublishingRecordsRegistriesReportingResearchResourcesSample SizeSamplingSelection BiasSourceSpousesSubgroupSuicideSuicide preventionSurvivorsTimeTraumaUnited StatesUnited States Department of Veterans AffairsWorkadverse outcomecohortcomorbiditycomparison groupcost efficientdata registrydesigneHealthemotional distressepidemiology studyexperiencefollow-uphigh riskimprovedlongitudinal designnovelphysical conditioningpopulation basedpreventsecondary analysissexsocialsociodemographicssuicidal individualsuicidal morbiditytherapy designtraumatic stressunsupervised learning
项目摘要
PROJECT ABSTRACT
The impact of suicide reaches well-beyond individual suicide decedents. For each suicide death, an estimated
135 people are exposed to the potential trauma of suicide loss. Research indicates that exposure to suicide
loss can result in mental and physical health distress, with those experiencing adverse outcomes called
“suicide loss survivors.” At the same time, the literature is severely limited by a lack of appropriate comparison
groups (e.g., accident death loss), examining a limited number of outcomes without considering comorbidity,
and focusing on one type of familial relation (e.g., spouses) while ignoring non-familial loss survivors (e.g.,
cohabitants). Consequently, the lack of high-quality population-level longitudinal epidemiologic studies of
suicide loss survivors hinders our ability to understand the full health effects of suicide and the full extent of the
suicide public health crisis. The overall goal of this project is to use Danish national registry data to document
the mental and physical health outcomes and comorbidities among the population of individuals exposed to
suicide loss over a 30-year period. Denmark has a universal healthcare system, with government supported
nationwide electronic health and social registries, and the ability to link records across registries and
individuals using unique personal/family identifiers and address information. Our project will leverage the
registries to directly address gaps in the suicide loss literature. We will develop a cohort of all first-degree
relatives and cohabitants exposed to suicide loss between 1994 and 2024, as well as two comparison cohorts
(1) exposed to accident loss, and (2) from the general population (Aim 1). The cohorts will include all available
socio-demographic and electronic medical record data over the 30-year follow-up period. These data will be
used to conduct an epidemiologic outcome-wide analysis of suicide loss (Aim 2). We will identify all mental and
physical health ICD-coded diagnostic outcomes that are specific to suicide loss (compared to accident loss and
the general population), and examine how outcomes vary by time since loss, relationship type, and sex. This
approach will inform novel and more precise targets for prevention and intervention within the field of suicide
postvention. The cohort also will be used to identify the most salient patterns of diagnostic comorbidity that
follow suicide loss (Aim 3). Unsupervised machine learning will identify latent subgroups of suicide loss
survivors characterized by common patterns of mental and physical health comorbidity, with the goal of
informing transdiagnostic prevention/treatment and generating mechanistic hypotheses. This study is an
efficient way to lay a foundation for the epidemiology of suicide loss. Our results will provide clinicians and
policymakers with the information needed to design and study both disorder-specific and transdiagnostic
interventions to prevent and treat currently unexplored and underexplored effects of suicide on loss survivors.
The cohort also can serve as an enduring resource for future research on suicide loss. Going forward, results
can be replicated across other populations (e.g., smaller US samples) to further contextualize our findings.
项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jaimie L. Gradus其他文献
Publisher Correction to: Time‑dependent suicide rates among Army soldiers returning from an Afghanistan/Iraq deployment, by military rank and component
- DOI:
10.1186/s40621-023-00432-x - 发表时间:
2023-04-24 - 期刊:
- 影响因子:2.200
- 作者:
Rachel Sayko Adams;Jeri E. Forster;Jaimie L. Gradus;Claire A. Hoffmire;Trisha A. Hostetter;Mary Jo Larson;Colin G. Walsh;Lisa A. Brenner - 通讯作者:
Lisa A. Brenner
Bias analysis of childhood trauma and probable post-traumatic stress disorder
- DOI:
10.1016/j.annepidem.2022.06.009 - 发表时间:
2022-09-01 - 期刊:
- 影响因子:
- 作者:
Sharonda M. Lovett;Matthew P. Fox;Jaimie L. Gradus;Amelia K. Wesselink;Renée Boynton-Jarrett;Yael I. Nillni;Lauren A. Wise - 通讯作者:
Lauren A. Wise
Gender and ethnoracial disparities in Veterans’ trauma exposure prevalence across differing life phases
- DOI:
10.1186/s40621-025-00561-5 - 发表时间:
2025-02-03 - 期刊:
- 影响因子:2.200
- 作者:
Fernanda S. Rossi;Yael I. Nillni;Alexandria N. Miller;Annie B. Fox;Johanne Eliacin;Paula P. Schnurr;Christopher C. Duke;Jaimie L. Gradus;Tara E. Galovski - 通讯作者:
Tara E. Galovski
State policies and suicidal behavior among sexual and gender minority college students
州政策与性少数和性别少数大学生的自杀行为
- DOI:
10.1007/s00127-025-02903-6 - 发表时间:
2025-04-21 - 期刊:
- 影响因子:3.500
- 作者:
Michelle Flesaker;Even Paglisotti;Christina E. Freibott;Jaimie L. Gradus;Sarah K. Lipson - 通讯作者:
Sarah K. Lipson
Posttraumatic Stress Disorder and Death From Suicide
- DOI:
10.1007/s11920-018-0965-0 - 发表时间:
2018-09-17 - 期刊:
- 影响因子:6.700
- 作者:
Jaimie L. Gradus - 通讯作者:
Jaimie L. Gradus
Jaimie L. Gradus的其他文献
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{{ truncateString('Jaimie L. Gradus', 18)}}的其他基金
Identifying Cardiotoxic Manifestations of Posttraumatic Psychopathology: A Population-based Longitudinal Investigation
识别创伤后精神病理学的心脏毒性表现:基于人群的纵向调查
- 批准号:
10344540 - 财政年份:2021
- 资助金额:
$ 73.83万 - 项目类别:
Identifying Cardiotoxic Manifestations of Posttraumatic Psychopathology: A Population-based Longitudinal Investigation
识别创伤后精神病理学的心脏毒性表现:基于人群的纵向调查
- 批准号:
10534712 - 财政年份:2021
- 资助金额:
$ 73.83万 - 项目类别:
Identification of Novel Agents to Treat PTSD using Clinical Data
利用临床数据鉴定治疗 PTSD 的新药
- 批准号:
10371100 - 财政年份:2020
- 资助金额:
$ 73.83万 - 项目类别:
Identification of Novel Agents to Treat PTSD using Clinical Data
利用临床数据鉴定治疗 PTSD 的新药
- 批准号:
10579848 - 财政年份:2020
- 资助金额:
$ 73.83万 - 项目类别:
Characterizing Trauma Outcomes: From Pre-trauma Risk to Post-trauma Sequelae
描述创伤结果:从创伤前风险到创伤后后遗症
- 批准号:
9309288 - 财政年份:2017
- 资助金额:
$ 73.83万 - 项目类别:
Constructing a Danish Reaction to Severe Stress Cohort
构建丹麦对严重压力队列的反应
- 批准号:
8300390 - 财政年份:2012
- 资助金额:
$ 73.83万 - 项目类别:
Constructing a Danish Reaction to Severe Stress Cohort
构建丹麦对严重压力队列的反应
- 批准号:
8450081 - 财政年份:2012
- 资助金额:
$ 73.83万 - 项目类别:
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