Identifying Cardiotoxic Manifestations of Posttraumatic Psychopathology: A Population-based Longitudinal Investigation
识别创伤后精神病理学的心脏毒性表现:基于人群的纵向调查
基本信息
- 批准号:10344540
- 负责人:
- 金额:$ 70.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-12-15 至 2025-11-30
- 项目状态:未结题
- 来源:
- 关键词:18 year oldAccidentsAccountingAddressAffectAnxietyAutomobile DrivingBig DataCardiotoxicityCardiovascular DiseasesCardiovascular systemCharacteristicsComplexComputerized Medical RecordDataData ScienceData SourcesDatabasesDevelopmentDiagnosisDisease OutcomeEventExposure toFutureHealthHeart DiseasesHeart failureHypertensionIncidenceIndividualInterventionInvestigationKnowledgeLinkLiteratureMachine LearningMeasuresMental DepressionMental disordersMyocardial InfarctionNational Heart, Lung, and Blood InstituteOutcomePatternPersonsPopulationPopulation-Based RegistryPost-Traumatic Stress DisordersPrevalencePreventionPsychopathologyPublic HealthRegistriesReportingResearchResourcesRiskRisk FactorsRoleSamplingSex DifferencesSmokingStrokeSubstance abuse problemTechniquesTimeTraumaUnited StatesWomanWorkassaultbasecardiovascular disorder preventioncardiovascular disorder riskcardiovascular healthcardiovascular risk factorcohortcomorbiditydata registryfollow-upimprovedmenmortalitynovelnovel strategiespopulation basedprimary outcomeprospectivepsychiatric comorbiditypsychologicresiliencerisk prediction modelsecondary outcomesexsubstance misusetrauma exposuretraumatic eventvenous thromboembolismvirtualworking group
项目摘要
PROJECT SUMMARY
Trauma affects the vast majority of people (50-89%) during their lifetime, and it can have lasting impacts on not
only psychiatric but also cardiovascular health. Both trauma exposure and posttraumatic stress disorder
(PTSD)—the quintessential trauma-related psychiatric disorder—have been linked prospectively to increased
risk of developing a range of cardiovascular outcomes. However, as described in a recent NHLBI Working
Group report, critical knowledge gaps must be addressed before trauma or its psychiatric sequelae might be
novel targets for reducing cardiovascular disease (CVD) risk. Indeed, our current understanding is limited by a
disproportionate focus on PTSD when examining subsequent CVD risk in trauma-exposed individuals.
Posttraumatic psychopathology manifests in heterogeneous ways (e.g., depression, anxiety, substance abuse)
that have been linked to elevated CVD risk in non-trauma-exposed samples. Further, despite differences in the
prevalence and manifestations of posttraumatic psychopathology and CVD in men and women, few studies
have directly examined sex differences in these associations. The field's ability to investigate these questions
has been hampered by a lack of rigorous measures of trauma exposure and posttraumatic psychopathology in
most existing electronic medical record databases, which have extensive data on CVD outcomes. This study
will address these knowledge gaps by harnessing a unique prospective, population-based trauma cohort in
order to characterize “cardiotoxic” manifestations of posttraumatic psychopathology in men and women. This
trauma cohort was created using Danish electronic health registry (EHR) data as part of R01MH110453 (PI:
Gradus), and it identified over 1.4 million individuals exposed to a trauma between 1994 and 2016. This
established data source includes rich, highly valid, and complete registry-based data with up to 25 years of
follow-up on psychiatric and cardiovascular diagnoses following trauma. We will use this existing resource,
restricted to persons age 18 years and older with no prior CVD events (n = 1,068,100), to comprehensively
examine posttraumatic psychopathology as a predictor of incident CVD. In Aim 1, we will harness cutting edge,
novel data science techniques (machine learning) to identify particularly “cardiotoxic” manifestations of
psychopathology after trauma. Given sex differences in psychiatric disorders and CVD, sex-specific
psychopathology profiles associated with incident CVD risk will be examined in stratified analyses. In Aim 2,
we will use traditional analyses to quantify discovered psychiatric predictors and unanticipated/novel
psychiatric comorbidity profiles associated with CVD risk in the machine learning analyses, as well as a priori
literature-based combinations of psychiatric disorders that increase CVD risk. This EHR-based trauma cohort
provides a unique opportunity to consider comprehensively the constellation of posttraumatic psychopathology
that may predict CVD, and the results of this study will be used to ultimately inform the development of
targeted CVD prevention efforts in trauma-exposed populations.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jaimie L. Gradus其他文献
Publisher Correction to: Time‑dependent suicide rates among Army soldiers returning from an Afghanistan/Iraq deployment, by military rank and component
- DOI:
10.1186/s40621-023-00432-x - 发表时间:
2023-04-24 - 期刊:
- 影响因子:2.200
- 作者:
Rachel Sayko Adams;Jeri E. Forster;Jaimie L. Gradus;Claire A. Hoffmire;Trisha A. Hostetter;Mary Jo Larson;Colin G. Walsh;Lisa A. Brenner - 通讯作者:
Lisa A. Brenner
Bias analysis of childhood trauma and probable post-traumatic stress disorder
- DOI:
10.1016/j.annepidem.2022.06.009 - 发表时间:
2022-09-01 - 期刊:
- 影响因子:
- 作者:
Sharonda M. Lovett;Matthew P. Fox;Jaimie L. Gradus;Amelia K. Wesselink;Renée Boynton-Jarrett;Yael I. Nillni;Lauren A. Wise - 通讯作者:
Lauren A. Wise
Gender and ethnoracial disparities in Veterans’ trauma exposure prevalence across differing life phases
- DOI:
10.1186/s40621-025-00561-5 - 发表时间:
2025-02-03 - 期刊:
- 影响因子:2.200
- 作者:
Fernanda S. Rossi;Yael I. Nillni;Alexandria N. Miller;Annie B. Fox;Johanne Eliacin;Paula P. Schnurr;Christopher C. Duke;Jaimie L. Gradus;Tara E. Galovski - 通讯作者:
Tara E. Galovski
State policies and suicidal behavior among sexual and gender minority college students
州政策与性少数和性别少数大学生的自杀行为
- DOI:
10.1007/s00127-025-02903-6 - 发表时间:
2025-04-21 - 期刊:
- 影响因子:3.500
- 作者:
Michelle Flesaker;Even Paglisotti;Christina E. Freibott;Jaimie L. Gradus;Sarah K. Lipson - 通讯作者:
Sarah K. Lipson
Posttraumatic Stress Disorder and Death From Suicide
- DOI:
10.1007/s11920-018-0965-0 - 发表时间:
2018-09-17 - 期刊:
- 影响因子:6.700
- 作者:
Jaimie L. Gradus - 通讯作者:
Jaimie L. Gradus
Jaimie L. Gradus的其他文献
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{{ truncateString('Jaimie L. Gradus', 18)}}的其他基金
Identifying the longitudinal outcomes of suicide loss in a population-based cohort
确定基于人群的队列中自杀损失的纵向结果
- 批准号:
10716673 - 财政年份:2023
- 资助金额:
$ 70.01万 - 项目类别:
Identifying Cardiotoxic Manifestations of Posttraumatic Psychopathology: A Population-based Longitudinal Investigation
识别创伤后精神病理学的心脏毒性表现:基于人群的纵向调查
- 批准号:
10534712 - 财政年份:2021
- 资助金额:
$ 70.01万 - 项目类别:
Identification of Novel Agents to Treat PTSD using Clinical Data
利用临床数据鉴定治疗 PTSD 的新药
- 批准号:
10371100 - 财政年份:2020
- 资助金额:
$ 70.01万 - 项目类别:
Identification of Novel Agents to Treat PTSD using Clinical Data
利用临床数据鉴定治疗 PTSD 的新药
- 批准号:
10579848 - 财政年份:2020
- 资助金额:
$ 70.01万 - 项目类别:
Characterizing Trauma Outcomes: From Pre-trauma Risk to Post-trauma Sequelae
描述创伤结果:从创伤前风险到创伤后后遗症
- 批准号:
9309288 - 财政年份:2017
- 资助金额:
$ 70.01万 - 项目类别:
Constructing a Danish Reaction to Severe Stress Cohort
构建丹麦对严重压力队列的反应
- 批准号:
8300390 - 财政年份:2012
- 资助金额:
$ 70.01万 - 项目类别:
Constructing a Danish Reaction to Severe Stress Cohort
构建丹麦对严重压力队列的反应
- 批准号:
8450081 - 财政年份:2012
- 资助金额:
$ 70.01万 - 项目类别:
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