Genomic and Microenvironment Analysis of HIV-Associated Diffuse Large B-cell Lymphoma (Immuno/Microenvironment)

HIV 相关弥漫性大 B 细胞淋巴瘤的基因组和微环境分析(免疫/微环境)

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT This proposal addresses the high priority statement related to “HIV-associated comorbidities, coinfections, and complications.” This study will be addressing this high priority requirement from two aspects, including the study of co-infection by EBV and HIV, as well as the molecular differences between EBV+ and EBV- diffuse large B- cell lymphoma in HIV+ patients. HIV-associated diffuse large B-cell lymphoma (HIV+/DLBCL) remains an understudied disease and is one of the leading causes of death in persons living with HIV on anti-retroviral therapy. Although there have been significant strides taken with de novo DLBCL in terms of molecular classification, HIV+/DLBCL has lagged behind, particularly because it was originally excluded from most large studies. While approximately 30% of these tumors can be EBV-positive, potentially serving as a driving mechanism for lymphomagenesis, the molecular pathogenesis in the majority of cases have not been comprehensively studied. Additionally, the tumor microenvironment (TME) plays an important role in lymphomas related to prognosis and therapy, but this area has not been investigated in HIV+/DLBCL. We hypothesize that by investigating the genomic landscape and TME of HIV+/DLBCL, we will identify key cellular vulnerabilities and pathways that can provide insights for tailoring novel therapies for patients with HIV+/EBV-positive versus HIV+/EBV-negative DLBCL. Utilizing our multi-institutional collaboration, we plan to evaluate the 1) whole “omics” of HIV+/DLBCL as well as 2) investigate the TME of HIV+/DLBCL using multispectral immunofluorescence in conjunction with spatial gene expression data, EBV-status, and genomic data. 3) We will utilize the Lymphoma and Leukemia Molecular Profiling Project (LLMPP) with their established pathology review and bioinformatics pipeline to facilitate this study which will generate important data that we and other investigators around the world can use in future years to generate new hypothesis, design targeted treatments and trials for this aggressive disease.
项目总结/文摘

项目成果

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STEVEN Terry ROSEN其他文献

STEVEN Terry ROSEN的其他文献

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{{ truncateString('STEVEN Terry ROSEN', 18)}}的其他基金

Novel targeted therapies for HPV-associated Non-AIDS-defining cancers (Biospecimens/Biocohort)
针对 HPV 相关非艾滋病定义癌症的新型靶向疗法(生物样本/生物队列)
  • 批准号:
    10620083
  • 财政年份:
    2022
  • 资助金额:
    $ 25万
  • 项目类别:
Caribbean Investigation of Cancer Stigma and its effect on Cervical Cancer Screening and HPV Vaccination
加勒比癌症耻辱调查及其对宫颈癌筛查和 HPV 疫苗接种的影响
  • 批准号:
    10406126
  • 财政年份:
    2021
  • 资助金额:
    $ 25万
  • 项目类别:
Creating an Efficient Clinical Trial Build System Via the Clinical Trials Rapid Activation Consortium (CTRAC)
通过临床试验快速激活联盟 (CTRAC) 创建高效的临床试验构建系统
  • 批准号:
    10227589
  • 财政年份:
    2020
  • 资助金额:
    $ 25万
  • 项目类别:
Targeting p38 gamma signaling to advance Cutaneous T Cell Lymphoma Therapy
靶向 p38 γ 信号传导以推进皮肤 T 细胞淋巴瘤治疗
  • 批准号:
    10525229
  • 财政年份:
    2018
  • 资助金额:
    $ 25万
  • 项目类别:
Targeting p38 gamma signaling to advance Cutaneous T Cell Lymphoma Therapy
靶向 p38 γ 信号传导以推进皮肤 T 细胞淋巴瘤治疗
  • 批准号:
    10057371
  • 财政年份:
    2018
  • 资助金额:
    $ 25万
  • 项目类别:
Targeting p38 gamma signaling to advance Cutaneous T Cell Lymphoma Therapy
靶向 p38 γ 信号传导以推进皮肤 T 细胞淋巴瘤治疗
  • 批准号:
    10296667
  • 财政年份:
    2018
  • 资助金额:
    $ 25万
  • 项目类别:
Novel RNA-Directed Therapy for the Treatment of Acute Myeloid Leukemia
治疗急性髓系白血病的新型 RNA 导向疗法
  • 批准号:
    9243226
  • 财政年份:
    2016
  • 资助金额:
    $ 25万
  • 项目类别:
Novel RNA-Directed Therapy for the Treatment of Acute Myeloid Leukemia
治疗急性髓系白血病的新型 RNA 导向疗法
  • 批准号:
    9107212
  • 财政年份:
    2016
  • 资助金额:
    $ 25万
  • 项目类别:
Novel RNA-Directed Therapy for the Treatment of Acute Myeloid Leukemia
治疗急性髓系白血病的新型 RNA 导向疗法
  • 批准号:
    9900748
  • 财政年份:
    2016
  • 资助金额:
    $ 25万
  • 项目类别:
Novel RNA-Directed Therapy for the Treatment of Acute Myeloid Leukemia
治疗急性髓系白血病的新型 RNA 导向疗法
  • 批准号:
    9458707
  • 财政年份:
    2016
  • 资助金额:
    $ 25万
  • 项目类别:

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