Together: Transforming and Translating Discovery to Improve Health

共同努力：转变和转化发现以改善健康

• 批准号: 10625179
• 负责人: DUANE A. MITCHELL
• 金额: $ 19.51万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10625179
• 关键词: Achievement; Address; Aging; Area; Catchment Area; Clinical; Clinical Informatics; Clinical Research; Clinical Sciences; Clinical Trials Network; Collaborations; Communities; Computer software; Country; Data; Development; Diagnosis; Disabled Persons; Ensure; Environment; Evaluation; Evolution; Faculty; Florida; Fostering; Funding; Genomic medicine; Geography; Goals; Good Clinical Practice; Guidelines; Health; Health Care Research; Health Priorities; Health system; Healthcare; Historically Black Colleges and Universities; Human; Informatics; Infrastructure; Institutes; Institution; Knowledge; Learning; Longevity; Medicaid; Mission; Modeling; Participant; Pathway interactions; Patient-Focused Outcomes; Performance; Phase; Policies; Population Heterogeneity; Prevention; Process; Research; Research Infrastructure; Research Personnel; Resources; Role; Rural Community; Science; Scientist; Site; Surgeon; TNFSF15 gene; Technology; Training; Translating; Translational Research; Translations; Trust; Underrepresented Minority; United States National Institutes of Health; Universities; Urban Community; Vision; Work; biomedical informatics; burden of illness; career development; catalyst; college; community engagement; evidence base; genomic data; human disease; implementation science; improved; innovation; metabolomics; new technology; next generation; novel; novel strategies; patient population; personalized medicine; precision medicine; programs; recruit; rural area; skills; success; training opportunity; translational pipeline; underserved community; urban area

Contact PD/PI: Nelson, David R Overall Abstract ABSTRACT Florida is a demographically and geographically diverse state. The University of Florida (UF) and Florida State University (FSU) CTSA hub will work within this environment to further the mission to improve human health by accelerating the translation of scientific discoveries and the implementation of evidence-based best practices for the diagnosis, treatment, prevention and cure of human diseases across the lifespan. The UF-FSU hub vision is “think globally, act locally”, offering research opportunities to underserved participants in North and North Central Florida, creating innovative career development and training opportunities, as well as collaborating across the country with the Accelerated Clinical Trials Network and PCORnet. Research strengths include precision medicine, team science, community engagement, implementation science and informatics which are conducted in diverse settings through the OneFlorida Clinical Research Consortium. The 2019-2024 period represents the next phase of evolution from creating a clinical and translational science infrastructure to enhancing the local, state and national impact of CTSI-led science. During this period, FSU will be integrated across all components and will engage six additional colleges. Hub activities will be centered around four strategic goals: (1) chart new pathways for developing the translational workforce by taking UF’s success in career development and translating this success to the FSU and historically black colleges and universities; (2) strengthen the capacity of the learning health system environment and develop transferable models for embedding translational science into the clinical enterprise by further integrating data and software, developing multi-site pilots in healthcare institutions serving unique patient populations and building on the success of the personalized medicine program to use genomics data to improve patient outcomes; (3) expand statewide collaborations and opportunities to advance a participant-centered research agenda that reflects the health priorities and diversity of the catchment area by continuing to strengthen stakeholder engagement and trust in research through the HealthStreet Program and enhance collaboration with policy stakeholders from Florida Medicaid, Florida surgeon general and others; and (4) strengthen regional and national collaborations to accelerate the collective impact of the CTSA network through continued work with ACT, PCORnet, genomic medicine, aging and metabolomics. Throughout this important work, the UF-FSU hub will remain dedicated to supporting the recruitment, retention and career development of underrepresented minority and disabled trainees and faculty. Integral to the success of the proposed work, the UF-FSU hub will further integrate health care and research in Florida guided by four keys to success: (1) organizational alignment, (2) clinical informatics, (3) clinician and stakeholder engagement, and (4) strong support from implementation and improvement science expertise. Page 415 Project Summary/Abstract Contact PD/PI: Nelson, David R Overall Narrative NARRATIVE The University of Florida (UF) and Florida State University (FSU) CTSA hub will work within the demographically and geographically diverse state of Florida to improve human health by accelerating the translation of scientific discoveries and the implementation of evidence-based best practices for the diagnosis, treatment, prevention and cure of human diseases across the lifespan. The 2019-2024 period represents the next phase of evolution from creating a clinical and translational science infrastructure to enhancing the local, state and national impact of CTSI-led science with a special emphasis on underserved and unique patient populations. Page 416

联系PD/PI：纳尔逊，大卫R 总体摘要 摘要 佛罗里达是一个人口结构和地理位置多样化的州。佛罗里达大学（UF）和佛罗里达州立大学 大学（FSU）CTSA中心将在这种环境中工作，以进一步的使命，以改善人类健康， 加快科学发现的转化和循证最佳做法的实施 用于诊断、治疗、预防和治愈人类疾病。UF-FSU集线器 愿景是“全球思考，当地行动”，为北部和南部地区服务不足的参与者提供研究机会， 中北部佛罗里达，创造创新的职业发展和培训机会，以及 在全国范围内与加速临床试验网络和PCORnet合作。研究 优势包括精准医学，团队科学，社区参与，实施科学和 通过OneFlorida临床研究联盟在不同环境中进行的信息学。的 2019-2024年期间代表了从创建临床和转化科学的下一个发展阶段 基础设施，以提高CTSI领导的科学的地方，州和国家的影响。在此期间，FSU 将整合所有组成部分，并将参与另外六所学院。中心活动将集中在 围绕四个战略目标：（1）通过采取UF的图表发展翻译劳动力的新途径 成功的职业发展，并将这一成功转化为FSU和历史上的黑人大学， 大学;（2）加强学习卫生系统环境的能力并发展可转移性 通过进一步整合数据和软件，将转化科学嵌入临床企业的模型， 在为独特患者群体服务的医疗机构中开展多站点试点， 成功的个性化医疗计划，使用基因组学数据，以改善病人的结果;（3）扩大 全州范围内的合作和机会，以推进以参与者为中心的研究议程，反映 通过继续加强利益攸关方的参与， 通过健康街计划信任研究，并加强与政策利益相关者的合作， 佛罗里达医疗补助计划、佛罗里达卫生局局长和其他人;以及（4）加强区域和国家合作 通过继续与ACT、PCORnet、基因组 医学、衰老和代谢组学。在这项重要工作中，UF-FSU中心将继续致力于 支持任职人数不足的少数族裔和残疾人的征聘、留用和职业发展 学员和教员。作为拟议工作取得成功的一部分，UF-FSU中心将进一步整合健康 佛罗里达的护理和研究由四个成功的关键指导：（1）组织调整，（2）临床 信息学，（3）临床医生和利益相关者的参与，以及（4）实施和 提高科学知识。 第415页 项目总结/摘要 联系PD/PI：纳尔逊，大卫R 整体叙事 叙事 佛罗里达大学（UF）和佛罗里达州立大学（FSU）CTSA中心将在 人口和地理上多样化的佛罗里达州，以改善人类健康，加快 科学发现的转化和实施基于证据的最佳诊断实践， 治疗，预防和治愈人类疾病的整个生命周期。2019-2024年期间代表了 下一阶段的发展，从创建临床和转化科学基础设施，以加强当地， CTSI领导科学对州和国家的影响，特别强调服务不足和独特的患者 人口。 第416页