Together: Transforming and Translating Discovery to Improve Health

联系PD/PI：Nelson，David R 总体摘要 摘要 佛罗里达州是一个人口和地理多样化的州。佛罗里达大学(UF)和佛罗里达州立大学 大学(FSU)CTSA中心将在这种环境下努力，通过以下方式促进改善人类健康的使命 加快科学发现的转化和循证最佳做法的实施 用于诊断、治疗、预防和治愈人类一生中的疾病。UF-FSU枢纽 愿景是“全球思考，本地化行动”，为北欧和南美服务不足的参与者提供研究机会。 佛罗里达州中北部，创造创新的职业发展和培训机会，以及 通过加速临床试验网络和PCORnet在全国范围内进行合作。研究 优势包括精准医学、团队科学、社区参与、实施科学和 信息学是通过One佛罗里达临床研究联盟在不同的环境中进行的。这个 2019年至2024年是临床和翻译科学发展的下一个阶段 基础设施，以加强CTSI领导的科学对地方、州和国家的影响。在此期间，FSU 将整合所有组成部分，并将聘请另外六所学院。枢纽活动将以 围绕四个战略目标：(1)通过使用UF制定发展翻译劳动力的新途径 在职业发展方面的成功，并将这种成功转化为FSU和历史上的黑人大学和 (2)加强学习卫生系统环境能力建设，发展可转移性 通过进一步集成数据和软件，将翻译科学嵌入临床企业的模型， 在医疗机构开展多地点试点，为独特的患者群体提供服务，并在 利用基因组学数据改善患者预后的个性化医疗计划的成功；(3)扩大 全州范围内的合作和机会，以推进以参与者为中心的研究议程，反映 健康优先事项和集水区的多样性，继续加强利益攸关方的参与和 通过HealthStreet计划信任研究，并加强与来自 佛罗里达州医疗补助、佛罗里达州卫生局局长等；以及(4)加强区域和国家合作 通过继续与ACT、PCORnet、基因组公司合作，加速CTSA网络的集体影响 医学、衰老和代谢组学。在这项重要工作中，UF-FSU中心将继续致力于 支持任职人数不足的少数群体和残疾人的招聘、保留和职业发展 实习生和教职员工。UF-FSU中心将进一步整合卫生保健，这是拟议工作取得成功不可或缺的一部分 佛罗里达州的护理和研究以四个成功关键为指导：(1)组织一致性，(2)临床 信息学，(3)临床医生和利益相关者的参与，以及(4)来自实施和 提高科学专业知识。 第415页 项目摘要/摘要 联系PD/PI：Nelson，David R 整体叙事 叙事 佛罗里达大学(UF)和佛罗里达州立大学(FSU)CTSA中心将在 人口和地理多样化的佛罗里达州通过加快 转化科学发现和实施基于证据的诊断最佳做法， 治疗、预防和治愈人类一生中的疾病。2019年至2024年代表着 下一阶段的发展从创建临床和转化科学基础设施到增强本地、 CTSI主导的科学对州和国家的影响，特别强调服务不足和独特的患者 人口。 第416页

Contact PD/PI: Nelson, David R Overall Abstract ABSTRACT Florida is a demographically and geographically diverse state. The University of Florida (UF) and Florida State University (FSU) CTSA hub will work within this environment to further the mission to improve human health by accelerating the translation of scientific discoveries and the implementation of evidence-based best practices for the diagnosis, treatment, prevention and cure of human diseases across the lifespan. The UF-FSU hub vision is “think globally, act locally”, offering research opportunities to underserved participants in North and North Central Florida, creating innovative career development and training opportunities, as well as collaborating across the country with the Accelerated Clinical Trials Network and PCORnet. Research strengths include precision medicine, team science, community engagement, implementation science and informatics which are conducted in diverse settings through the OneFlorida Clinical Research Consortium. The 2019-2024 period represents the next phase of evolution from creating a clinical and translational science infrastructure to enhancing the local, state and national impact of CTSI-led science. During this period, FSU will be integrated across all components and will engage six additional colleges. Hub activities will be centered around four strategic goals: (1) chart new pathways for developing the translational workforce by taking UF’s success in career development and translating this success to the FSU and historically black colleges and universities; (2) strengthen the capacity of the learning health system environment and develop transferable models for embedding translational science into the clinical enterprise by further integrating data and software, developing multi-site pilots in healthcare institutions serving unique patient populations and building on the success of the personalized medicine program to use genomics data to improve patient outcomes; (3) expand statewide collaborations and opportunities to advance a participant-centered research agenda that reflects the health priorities and diversity of the catchment area by continuing to strengthen stakeholder engagement and trust in research through the HealthStreet Program and enhance collaboration with policy stakeholders from Florida Medicaid, Florida surgeon general and others; and (4) strengthen regional and national collaborations to accelerate the collective impact of the CTSA network through continued work with ACT, PCORnet, genomic medicine, aging and metabolomics. Throughout this important work, the UF-FSU hub will remain dedicated to supporting the recruitment, retention and career development of underrepresented minority and disabled trainees and faculty. Integral to the success of the proposed work, the UF-FSU hub will further integrate health care and research in Florida guided by four keys to success: (1) organizational alignment, (2) clinical informatics, (3) clinician and stakeholder engagement, and (4) strong support from implementation and improvement science expertise. Page 415 Project Summary/Abstract Contact PD/PI: Nelson, David R Overall Narrative NARRATIVE The University of Florida (UF) and Florida State University (FSU) CTSA hub will work within the demographically and geographically diverse state of Florida to improve human health by accelerating the translation of scientific discoveries and the implementation of evidence-based best practices for the diagnosis, treatment, prevention and cure of human diseases across the lifespan. The 2019-2024 period represents the next phase of evolution from creating a clinical and translational science infrastructure to enhancing the local, state and national impact of CTSI-led science with a special emphasis on underserved and unique patient populations. Page 416