Together: Transforming and Translating Discovery to Improve Health

共同努力：转变和转化发现以改善健康

• 批准号: 10440250
• 负责人: DUANE A. MITCHELL
• 金额: $ 340.33万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440250
• 关键词: Achievement; Address; Aging; Area; Catchment Area; Clinical; Clinical Informatics; Clinical Research; Clinical Sciences; Clinical Trials Network; Collaborations; Communities; Computer software; Country; Data; Development; Diagnosis; Disabled Persons; Ensure; Environment; Evaluation; Evolution; Faculty; Florida; Fostering; Funding; Genomic medicine; Geography; Goals; Good Clinical Practice; Guidelines; Health; Health Care Research; Health Priorities; Health system; Healthcare; Historically Black Colleges and Universities; Human; Informatics; Infrastructure; Institutes; Institution; Knowledge; Learning; Longevity; Medicaid; Mission; Modeling; Participant; Pathway interactions; Patient-Focused Outcomes; Performance; Phase; Policies; Population Heterogeneity; Prevention; Process; Research; Research Infrastructure; Research Personnel; Resources; Role; Rural Community; Science; Scientist; Site; Surgeon; TNFSF15 gene; Technology; Training; Translating; Translational Research; Translations; Trust; Underrepresented Minority; United States National Institutes of Health; Universities; Urban Community; Vision; Work; biomedical informatics; burden of illness; career development; catalyst; college; community engagement; evidence base; genomic data; human disease; implementation science; improved; innovation; metabolomics; new technology; next generation; novel; novel strategies; patient population; personalized medicine; precision medicine; programs; recruit; rural area; skills; success; training opportunity; translational pipeline; underserved community; urban area

Contact PD/PI: Nelson, David R Overall Abstract ABSTRACT Florida is a demographically and geographically diverse state. The University of Florida (UF) and Florida State University (FSU) CTSA hub will work within this environment to further the mission to improve human health by accelerating the translation of scientific discoveries and the implementation of evidence-based best practices for the diagnosis, treatment, prevention and cure of human diseases across the lifespan. The UF-FSU hub vision is “think globally, act locally”, offering research opportunities to underserved participants in North and North Central Florida, creating innovative career development and training opportunities, as well as collaborating across the country with the Accelerated Clinical Trials Network and PCORnet. Research strengths include precision medicine, team science, community engagement, implementation science and informatics which are conducted in diverse settings through the OneFlorida Clinical Research Consortium. The 2019-2024 period represents the next phase of evolution from creating a clinical and translational science infrastructure to enhancing the local, state and national impact of CTSI-led science. During this period, FSU will be integrated across all components and will engage six additional colleges. Hub activities will be centered around four strategic goals: (1) chart new pathways for developing the translational workforce by taking UF’s success in career development and translating this success to the FSU and historically black colleges and universities; (2) strengthen the capacity of the learning health system environment and develop transferable models for embedding translational science into the clinical enterprise by further integrating data and software, developing multi-site pilots in healthcare institutions serving unique patient populations and building on the success of the personalized medicine program to use genomics data to improve patient outcomes; (3) expand statewide collaborations and opportunities to advance a participant-centered research agenda that reflects the health priorities and diversity of the catchment area by continuing to strengthen stakeholder engagement and trust in research through the HealthStreet Program and enhance collaboration with policy stakeholders from Florida Medicaid, Florida surgeon general and others; and (4) strengthen regional and national collaborations to accelerate the collective impact of the CTSA network through continued work with ACT, PCORnet, genomic medicine, aging and metabolomics. Throughout this important work, the UF-FSU hub will remain dedicated to supporting the recruitment, retention and career development of underrepresented minority and disabled trainees and faculty. Integral to the success of the proposed work, the UF-FSU hub will further integrate health care and research in Florida guided by four keys to success: (1) organizational alignment, (2) clinical informatics, (3) clinician and stakeholder engagement, and (4) strong support from implementation and improvement science expertise. Page 415 Project Summary/Abstract Contact PD/PI: Nelson, David R Overall Narrative NARRATIVE The University of Florida (UF) and Florida State University (FSU) CTSA hub will work within the demographically and geographically diverse state of Florida to improve human health by accelerating the translation of scientific discoveries and the implementation of evidence-based best practices for the diagnosis, treatment, prevention and cure of human diseases across the lifespan. The 2019-2024 period represents the next phase of evolution from creating a clinical and translational science infrastructure to enhancing the local, state and national impact of CTSI-led science with a special emphasis on underserved and unique patient populations. Page 416

联系 PD/PI：Nelson, David R 总体摘要 抽象的 佛罗里达州是一个人口和地理多元化的州。佛罗里达大学 (UF) 和佛罗里达州立大学 大学 (FSU) CTSA 中心将在这种环境下工作，通过以下方式进一步推进改善人类健康的使命： 加速科学发现的转化和基于证据的最佳实践的实施 用于人类整个生命周期疾病的诊断、治疗、预防和治愈。 UF-FSU 枢纽 愿景是“全球化思考，本地化行动”，为北部和北部服务不足的参与者提供研究机会 佛罗里达州中北部，创造创新的职业发展和培训机会，以及 与加速临床试验网络和 PCORnet 在全国范围内合作。研究 优势包括精准医疗、团队科学、社区参与、实施科学和 通过 OneFlorida 临床研究联盟在不同环境中进行的信息学研究。这 2019-2024 年期间代表了从创建临床和转化科学到发展的下一阶段 基础设施，以增强 CTSI 主导的科学对地方、州和国家的影响。在此期间，前苏联 将整合所有组成部分，并将与另外六所大学合作。枢纽活动将集中 围绕四个战略目标：（1）通过利用佛罗里达大学的 职业发展方面的成功，并将这种成功转化为佛罗里达州立大学和历史悠久的黑人大学 大学； (2) 加强学习健康系统环境的能力并开发可转移的 通过进一步整合数据和软件将转化科学嵌入临床企业的模型， 在医疗机构中开展多站点试点，为独特的患者群体提供服务，并在此基础上 利用基因组数据改善患者治疗效果的个性化医疗计划取得成功； (3) 展开 全州范围内的合作和机会，以推进以参与者为中心的研究议程，该议程反映了 通过继续加强利益相关者的参与和 通过 HealthStreet 计划增强对研究的信任，并加强与政策利益相关者的合作 佛罗里达州医疗补助计划、佛罗里达州卫生局局长等； (4) 加强区域和国家合作 通过与 ACT、PCORnet、基因组学的持续合作，加速 CTSA 网络的集体影响 医学、衰老和代谢组学。在这项重要工作的整个过程中，UF-FSU 中心将继续致力于 支持代表性不足的少数族裔和残疾人的招聘、保留和职业发展 实习生和教员。作为拟议工作成功的一部分，UF-FSU 中心将进一步整合健康 佛罗里达州的护理和研究遵循四个成功关键：(1) 组织协调，(2) 临床 信息学，(3) 临床医生和利益相关者的参与，以及 (4) 实施和实施的大力支持 提高科学专业知识。 第415页 项目概要/摘要 联系 PD/PI：Nelson, David R 整体叙述 叙述 佛罗里达大学 (UF) 和佛罗里达州立大学 (FSU) CTSA 中心将在 人口和地理多样化的佛罗里达州通过加速改善人类健康 翻译科学发现并实施基于证据的最佳诊断实践， 治疗、预防和治愈人类整个生命周期的疾病。 2019年至2024年期间代表 下一阶段的发展从创建临床和转化科学基础设施到加强当地、 CTSI 主导的科学对州和国家的影响，特别强调服务不足和独特的患者 人口。 第416页