Imaging Core

成像核心

基本信息

  • 批准号:
    10624201
  • 负责人:
  • 金额:
    $ 17.33万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-08-01 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

Project Summary Yale Cooperative Center of Excellence in Hematology Imaging Core The Imaging Core of the YCCEH has provided access to state-of-the-art microscopy for benign hematology to progressively more users each year. In this renewal, we propose to continue operations with enhancements including longterm timelapse with decreased phototoxicity, adapted super resolution imaging for hematopoietic tissues and automated high-throughput microscopy for imaging of 1,000 to 10,000 cells/24 hrs at super- resolution. Hematopoiesis is a complex and dynamic process involving many heterologous cell types. Due to the rich spatial and/or temporal information contained in imaging data, imaging is uniquely powerful in revealing the influences of cellular dynamics and tissue organization on the relevant cells and states. As many hematopoietic cells are small in size, minimally adhesive, difficult to manipulate genetically, reside in deep tissues, highly dynamic and/or exceedingly rare, the ability to apply imaging approaches to hematopoiesis research has been limited to few laboratories with the requisite technical expertise and instrumentation. YCCEH Imaging Core aims to reduce the high technical hurdle and promote the application of imaging techniques for hematopoietic research. Yale is the home of many state-of-the-art imaging equipment and facilities overseen by world-renowned leaders and experts in microscopy. The YCCEH Imaging Core will make the large array of imaging platforms readily accessible to all investigators with a research interest in hematopoiesis, locally or nationally. YCCEH Imaging Core will continue to provide its members with access to state-of-the-art instrumentation including widefield, confocal, 2-photon and flow cytometry imaging. Importantly, through this Imaging Core, we are making it available as a service, access to and expertise in using innovative imaging modalities including automated long-term live-cell time-lapse microscopy, optical clearing of tissue and super-resolution microscopy. The directors of the Core, Drs. Bewersdorf and Guo will act as liaisons between YCCEH members and the participating facilities and labs and will help identifying most suitable techniques for individual research projects. The Imaging Core will also support two part time imaging specialists who will train YCCEH members, maintain the instruments provided by the Bewersdorf and Guo labs and assist with reagents, sample preparation and data analysis. We will continue to promote the dissemination of knowledge for imaging in hematopoietic research by organizing symposia, workshops, seminars and training with an emphasis on students, trainees and other early-stage investigators. Furthermore, the Imaging Core will continue to develop, optimize and disseminate innovative reporters/probes that are suitable for analyzing hematopoietic cells by fluorescence imaging and/or flow cytometry. We will continue to encourage YCCEH members to evaluate various microscopy techniques for their research projects through the user incentive program, by eliminating the psychological hurdle of investing funds into an unfamiliar technical domain. Overall, the Imaging Core will facilitate and enable individual hematopoietic researchers to make observations of their specific hematopoietic cell linages, using approaches that can provide unique structural, functional and/or dynamic information.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Joerg Bewersdorf其他文献

Joerg Bewersdorf的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Joerg Bewersdorf', 18)}}的其他基金

Development of a Versatile Multiplexing Nanoscopy Platform for Cell Biology
细胞生物学多功能多重纳米显微镜平台的开发
  • 批准号:
    10753760
  • 财政年份:
    2023
  • 资助金额:
    $ 17.33万
  • 项目类别:
Development of pan-Expansion Microscopy to reveal mechanisms underlying epidermal differentiation
开发泛膨胀显微镜以揭示表皮分化的机制
  • 批准号:
    10662553
  • 财政年份:
    2022
  • 资助金额:
    $ 17.33万
  • 项目类别:
Development of pan-Expansion Microscopy to reveal mechanisms underlying epidermal differentiation
开发泛膨胀显微镜以揭示表皮分化的机制
  • 批准号:
    10539999
  • 财政年份:
    2022
  • 资助金额:
    $ 17.33万
  • 项目类别:
Imaging Core
成像核心
  • 批准号:
    10677847
  • 财政年份:
    2015
  • 资助金额:
    $ 17.33万
  • 项目类别:
An Integrated Imaging System for High-throughput Nanoscopy of the 4D Nucleome
用于 4D 核组高通量纳米显微成像的集成成像系统
  • 批准号:
    9308968
  • 财政年份:
    2015
  • 资助金额:
    $ 17.33万
  • 项目类别:
Imaging Core
成像核心
  • 批准号:
    10249342
  • 财政年份:
    2015
  • 资助金额:
    $ 17.33万
  • 项目类别:
Imaging Core
成像核心
  • 批准号:
    10060458
  • 财政年份:
    2015
  • 资助金额:
    $ 17.33万
  • 项目类别:
4PI MICROSCOPY
4PI显微镜
  • 批准号:
    8169625
  • 财政年份:
    2010
  • 资助金额:
    $ 17.33万
  • 项目类别:
4PI MICROSCOPY
4PI显微镜
  • 批准号:
    7957636
  • 财政年份:
    2009
  • 资助金额:
    $ 17.33万
  • 项目类别:
4PI MICROSCOPY
4PI显微镜
  • 批准号:
    7722473
  • 财政年份:
    2008
  • 资助金额:
    $ 17.33万
  • 项目类别:

相似海外基金

Genome analysis-based prediction model development for response to stereotactic radiosurgery in benign brain tumors
基于基因组分析的预测模型开发,用于良性脑肿瘤立体定向放射外科治疗的反应
  • 批准号:
    23K08495
  • 财政年份:
    2023
  • 资助金额:
    $ 17.33万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Clinical breast cancer risk prediction models for women with a high-risk benign breast diagnosis
高风险良性乳腺诊断女性的临床乳腺癌风险预测模型
  • 批准号:
    10719777
  • 财政年份:
    2023
  • 资助金额:
    $ 17.33万
  • 项目类别:
Environmentally Benign Precise Transformations of Alkenes by Chiral Chalcogenide Catalysts
手性硫属化物催化剂对环境无害的烯烃精确转化
  • 批准号:
    22KJ2498
  • 财政年份:
    2023
  • 资助金额:
    $ 17.33万
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
Learners to LeAders in benign Urology, benign Nephrology, and non-Cancer Hematology
良性泌尿外科、良性肾脏病学和非癌症血液学领域的学习者和领导者
  • 批准号:
    10726042
  • 财政年份:
    2023
  • 资助金额:
    $ 17.33万
  • 项目类别:
The role of estrogen receptor alpha in prostatic fibrosis contributing to benign prostatic hyperplasia
雌激素受体α在导致良性前列腺增生的前列腺纤维化中的作用
  • 批准号:
    10607151
  • 财政年份:
    2023
  • 资助金额:
    $ 17.33万
  • 项目类别:
Development of a medical device to resolve benign esophageal stricture by heating and traction
开发通过加热和牵引解决良性食管狭窄的医疗设备
  • 批准号:
    23H03765
  • 财政年份:
    2023
  • 资助金额:
    $ 17.33万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of benign/malignant differentiation method for thyroid follicular tumor using organoids
利用类器官开发甲状腺滤泡性肿瘤良恶性鉴别方法
  • 批准号:
    23K08075
  • 财政年份:
    2023
  • 资助金额:
    $ 17.33万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Mechanisms of p53 Engagement and Action at the Benign-to-Malignant Transition in Sporadic Tumorigenesis
p53在散发性肿瘤发生良性向恶性转变中的参与和作用机制
  • 批准号:
    10720034
  • 财政年份:
    2023
  • 资助金额:
    $ 17.33万
  • 项目类别:
I-Corps: Mitigating Multidrug Resistant Bacterial Infections with Biocompatible and Environmentally Benign Nanoantibiotics
I-Corps:利用生物相容性且对环境无害的纳米抗生素减轻多重耐药细菌感染
  • 批准号:
    2306943
  • 财政年份:
    2023
  • 资助金额:
    $ 17.33万
  • 项目类别:
    Standard Grant
Towards Achieving Zero Emissions through the use of an Environmentally Benign Non-Regenerable Solvent to Capture CO2 from Large Point Source Emitters for Direct Permanent Storage in Geological Formation or Usage in Accelerated Curing of Ready-mix Con
通过使用环境友好的不可再生溶剂从大型点源排放器捕获二氧化碳,直接永久储存在地质构造中或用于预拌混凝土的加速固化,从而实现零排放
  • 批准号:
    RGPIN-2022-03431
  • 财政年份:
    2022
  • 资助金额:
    $ 17.33万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了