The Transmission Biology of Mycobacterium Tuberculosis

结核分枝杆菌的传播生物学

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT Christopher Brown MD, PhD is an Instructor of Medicine in the division of infectious diseases at Weill- Cornell Medical College in New York City. His research interests focus on defining the biology of transmission in Mycobacterium tuberculosis. This five-year training grant outlines technical, research and professionalism goals needed to launch an independent academic career. Dr. Brown has extensive research training as an organic chemist and chemical biologist from his doctoral work in the laboratory of Laura L. Kiessling. This proposal expands into the fields of microbiology, metabolomics and regulated gene expression. Utilizing a combination of these disciplines is a powerful method for the molecular interrogation of biological systems. Mtb transmission biology is a field of substantial opportunity for discovery. Development of a transmission blocking therapy would have a profound impact on global health and mortality. The research goal of this proposal is to identify bacterially-encoded determinants that favor successful transmission by imparting survival in air. The PI will expose laboratory and clinical strains of Mtb to air-drying stress and document the effects on metabolism and cellular integrity. Hypotheses regarding the essentiality of metabolic pathways for survival will be tested using CRISPRi (clustered regularly interspersed short palindromic repeat interference) gene silencing.
项目总结/文摘

项目成果

期刊论文数量(0)
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Christopher David Brown其他文献

Christopher David Brown的其他文献

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{{ truncateString('Christopher David Brown', 18)}}的其他基金

The Transmission Biology of Mycobacterium Tuberculosis
结核分枝杆菌的传播生物学
  • 批准号:
    10301479
  • 财政年份:
    2021
  • 资助金额:
    $ 19.49万
  • 项目类别:
The Transmission Biology of Mycobacterium Tuberculosis
结核分枝杆菌的传播生物学
  • 批准号:
    10436357
  • 财政年份:
    2021
  • 资助金额:
    $ 19.49万
  • 项目类别:
Epigenetic fine-mapping of cardiometabolic disease loci in the human liver
人类肝脏心脏代谢疾病位点的表观遗传精细定位
  • 批准号:
    9309707
  • 财政年份:
    2017
  • 资助金额:
    $ 19.49万
  • 项目类别:
Integrated target discovery in Alzheimer's disease
阿尔茨海默病的综合靶标发现
  • 批准号:
    9285327
  • 财政年份:
    2017
  • 资助金额:
    $ 19.49万
  • 项目类别:
Identification and validation of cell specific eQTLs by Bayesian modeling
通过贝叶斯模型识别和验证细胞特异性 eQTL
  • 批准号:
    8878357
  • 财政年份:
    2013
  • 资助金额:
    $ 19.49万
  • 项目类别:
Identification and validation of cell specific eQTLs by Bayesian modeling
通过贝叶斯模型识别和验证细胞特异性 eQTL
  • 批准号:
    8586116
  • 财政年份:
    2013
  • 资助金额:
    $ 19.49万
  • 项目类别:
Identification and validation of cell specific eQTLs by Bayesian modeling
通过贝叶斯模型识别和验证细胞特异性 eQTL
  • 批准号:
    8708217
  • 财政年份:
    2013
  • 资助金额:
    $ 19.49万
  • 项目类别:

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考虑适用于 COVID-19 的供暖通风和空调 (HVAC) 系统的机舱内气溶胶 CFD 建模的实验验证
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用于空气质量评估中超细气溶胶化学成分分析的多光谱传感器
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    2022
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Using satellites to map the spatial characteristics of urban air pollution from aerosols at a time of climate change, health choices and pandemics
利用卫星绘制气候变化、健康选择和流行病时期城市气溶胶空气污染的空间特征
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CINDAER 室内气溶胶的成分及其对空气质量的作用
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考虑适用于 COVID-19 的供暖通风和空调 (HVAC) 系统的机舱内气溶胶 CFD 建模的实验验证
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开发手持式快速空气传感系统,实时监测和量化气溶胶中的 SARS-CoV-2
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