Graduate Training in Cellular and Molecular Pathogenesis of Human Diseases

人类疾病的细胞和分子发病机制研究生培训

• 批准号: 10620761
• 负责人: Zsuzsanna Fabry
• 金额: $ 31.83万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620761
• 关键词: Molecular; Pathogenesis; Training; human disease

PROJECT SUMMARY/ABSTRACT The Cellular and Molecular Pathology (CMP) Graduate Training Program is a joint venture of the University of Wisconsin (UW)-Madison Graduate School, the Department of Pathology & Laboratory Medicine and the School of Medicine and Public Health (SMPH). CMP provides rigorous didactic training in fundamental basic biomedical sciences combined with interdisciplinary and innovative training in the pathogenesis of major human diseases. The goal of the CMP program is to create a stimulating and robust intellectual environment for predoctoral training embedded in a dynamic basic and clinical translational research atmosphere in order to develop the skills needed to move biological knowledge toward clinical application. Biomedical Graduate Training for the future demands that first rate academic scientists graduate with appropriate operational, technical and professional skills that will position them for diverse bioscience careers in academia, industry or government. The primary mission of the CMP program is to answer this demand and prepare our graduates for productive careers in the rapidly evolving biomedical research field. The program provides operational (in-depth knowledge, rigorous and reproducible experimental design, critical thinking), technical (teaching state-of-the-art methods, rigor and reproducibility) and professional (career development, IDPs and other opportunities) skills to ensure student success. The overall objective of CMP is to educate trainees so that they have a fundamental knowledge of pathology and molecular medicine, and have an in-depth research experience that combines pathobiological and translational clinical research. CMP’s specific objective is to ensure optimal PhD completion rates and time-to-degree with the implementation of monitored IDPs, student success and progress monitoring. CMP objectives will integrate measurable outcomes the program intends to achieve, such as appropriate completion rates, career placement outcomes and student retention rates. The Program draws 85 PhD, MD/PhD or MD funded faculty trainers from 24 departments. We are requesting training of eight pre-doctoral students under the Molecular Medicine Program. Trainees will be supported in the first or second year of their training. Candidates will be selected based on commitment to research documented by research experience, letters of recommendation and the potential to enhance diversity and make significant contributions toward the health-related research needs of our nation. Our curriculum provides interdisciplinary and integrated training in fundamental concepts in modern pathobiology with an emphasis on biochemical, cellular and molecular approaches to the study of human disease, including training in statistics, rigor and reproducibility and responsible conduct in research. CMP helps students to develop teaching and leadership skills through committee service, presentations and workshop teaching. The proposed program provides the fundamental knowledge base, research experience, and understanding of translational clinical research necessary for the success of our graduates.

项目总结/摘要 细胞和分子病理学（CMP）研究生培训计划是一个合资企业的大学， 威斯康星州（UW）-麦迪逊研究生院，病理学与实验室医学系和 医学与公共卫生学院（SMPH）。CMP提供严格的基础教育培训， 生物医学科学与主要发病机制的跨学科和创新培训相结合 人类疾病。CMP计划的目标是创造一个刺激和强大的智力环境 博士前培训嵌入在一个充满活力的基础和临床转化研究的氛围，以 培养将生物学知识推向临床应用所需的技能。生物医学研究生 未来的培训要求一流的学术科学家毕业于适当的操作， 技术和专业技能，这将使他们在学术界，工业界的各种生物科学职业生涯 或者政府CMP计划的主要使命是满足这一需求， 毕业生在快速发展的生物医学研究领域的生产性职业。该计划提供 操作（深入的知识，严格和可重复的实验设计，批判性思维），技术 （教授最先进的方法、严谨性和可重复性）和专业（职业发展、国内流离失所者和 其他机会）技能，以确保学生的成功。CMP的总体目标是教育学员， 他们有病理学和分子医学的基础知识，并有深入的研究， 结合病理生物学和转化临床研究的经验。CMP的具体目标是 确保最佳的博士学位完成率和时间与实施监测国内流离失所者，学生 成功和进展监测。CMP目标将整合可衡量的成果，该计划打算 实现，如适当的完成率，职业安置结果和学生保留率。的 该计划吸引了来自24个部门的85名博士，MD/PhD或MD资助的教师培训师。我们要求 在分子医学项目下培养了8名博士前学生。学员将得到以下方面的支持： 第一年或第二年的训练。候选人将根据对研究的承诺进行选择 通过研究经验、推荐信和增强多样性的潜力来记录， 为我们国家的健康相关研究需求做出重大贡献。我们的课程提供 现代病理生物学基本概念的跨学科和综合培训，重点是 研究人类疾病的生物化学、细胞和分子方法，包括统计学培训， 严谨性和可重复性以及负责任的研究行为。CMP帮助学生发展教学， 通过委员会服务，演讲和研讨会教学的领导技能。拟议程序 提供基本的知识基础，研究经验，并了解转化临床 我们的毕业生的成功所需的研究。

项目成果

Consistent ultra-long DNA sequencing with automated slow pipetting.

• DOI: 10.1186/s12864-021-07500-w
• 发表时间: 2021-03-12
• 期刊: BMC genomics
• 影响因子: 4.4
• 作者: Prall TM;Neumann EK;Karl JA;Shortreed CG;Baker DA;Bussan HE;Wiseman RW;O'Connor DH
• 通讯作者: O'Connor DH

Trimethylamine N-Oxide Reduces Neurite Density and Plaque Intensity in a Murine Model of Alzheimer's Disease.

• DOI: 10.3233/jad-220413
• 发表时间: 2022
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Zarbock, Katie R.;Han, Jessica H.;Singh, Ajay P.;Thomas, Sydney P.;Bendlin, Barbara B.;Denu, John M.;Yu, John-Paul J.;Rey, Federico E.;Ulland, Tyler K.
• 通讯作者: Ulland, Tyler K.

Interleukin-1α Is a Critical Mediator of the Response of Human Bronchial Fibroblasts to Eosinophilic Inflammation.

• DOI: 10.3390/cells10030528
• 发表时间: 2021-03-02
• 期刊: Cells
• 影响因子: 6
• 作者: Bernau K;Leet JP;Floerke H;Bruhn EM;Noll AL;McDermott IS;Esnault S;Jarjour NN;Sandbo N
• 通讯作者: Sandbo N