Molecular Mycology: Current Approaches to Fungal Pathogenesis (MoMy) Training Course

分子真菌学：真菌发病机制的最新方法 (MoMy) 培训课程

• 批准号: 10664997
• 负责人: David R Andes
• 金额: $ 10.81万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-04 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664997
• 关键词: Achievement; Address; Affect; Animal Model; Anniversary; Antifungal Agents; Authorship; Biological; Biology; Biomedical Research; Clinical; Collaborations; Communities; Data; Development; Development Plans; Disease; Education; Ethics; Faculty; Funding; Fungi Model; Future; Grant; Health; Human; Humanities; Immune; Immune response; Immunology; Incidence; Instruction; Knowledge; Laboratories; Medical; Mentors; Methods; Microscopy; Mission; Molecular; Molecular Biology; Morbidity - disease rate; Mycoses; National Institute of Allergy and Infectious Disease; Nursing Faculty; Paper; Participant; Pathogenesis; Personal Satisfaction; Pharmaceutical Preparations; Physicians; Positioning Attribute; Procedures; Publishing; Recommendation; Recording of previous events; Research; Research Personnel; Role; Science; Scientist; Students; Surveys; Techniques; Technology; The science of Mycology; Therapeutic; Training; Underrepresented Minority; United States National Institutes of Health; Writing; career; data sharing; drug development; experience; experimental study; faculty mentor; fungus; hands-on learning; immunoregulation; marine; meetings; microbiome components; mortality; novel; pathogen; patient population; peer; programs; research faculty; response; responsible research conduct; skill acquisition; skills; skills training; tenure track

PROJECT SUMMARY The purpose of this application is to support the Molecular Mycology and Pathogenesis education program (MOMY) at the Marine Biological Laboratory (MBL) in Woods Hole, MA. MOMY is now approaching its 25th anniversary at the MBL. Over the course’s history it has provided pivotal training for a scientific workforce to meet the world’s biomedical research needs related to the growing incidence of, and limited therapeutic options for, human fungal infections. Simply put, there is an urgent need for new research with human fungal infections given the rapid advances in immune modulating medical therapies that often result in opportunistic fungal infections. MOMY has addressed both the significant impact of fungi on morbidity and mortality in immune compromised patient populations, as well as the role of fungi as microbiome components that affect health and disease. Our intensive and immersive MOMY program provides trainees hands-on laboratory skill training by leading scientists in the fields of fungal biology, immunology & host response, and antifungal drug development. These skills are critical to develop and promote a well-trained workforce in the face of the growing threat posed by fungi to human well-being. MOMY’s objective during the 2 week course is to provide foundational knowledge and training in the techniques, procedures, and concepts in molecular mycology through direct experiences working with fungi and animal models of fungal disease. Importantly, MOMY provides critical career mentoring and professional development opportunities throughout the course to all participants. We achieve our objective in part through the participation of a diverse and committed faculty who are leading experts from the mycology community. Our specifics aims are: (1) To provide in-depth instruction on fundamental contemporary skills in molecular medical mycology; (2) To provide mentored research opportunities based on cutting edge methods and concepts in molecular medical mycology; and (3) To provide trainees with career mentoring, including professional development advice, science ethics training, and development of a lifelong professional mentoring network. Overall, MOMY has a long history of successfully meeting these aims to advance the NIH Mission and advance our ability to ask, explore, and answer critical questions related to the impact of fungi on human health. The course remains of utmost significance given the increasing scope and incidence of fungi’s impact on humanity and the rapid research technological and conceptual advances occurring in our field.

项目摘要 此申请的目的是支持分子真菌学和发病机制教育计划 （MOMY）在马萨诸塞州伍兹霍尔的海洋生物实验室（MBL）进行。MOMY现在接近25岁 在MBL的周年纪念日在课程的历史上，它为科学工作者提供了关键的培训， 满足世界生物医学研究的需要，相关的发病率不断增加，治疗有限， 人类真菌感染的可能性简而言之，迫切需要对人类进行新的研究。 由于免疫调节医学疗法的快速发展，真菌感染经常导致 机会性真菌感染MOMY已经解决了真菌对发病率的重大影响， 免疫受损患者人群的死亡率，以及真菌作为微生物组的作用 影响健康和疾病的成分。我们的密集和身临其境的MOMY计划为学员提供 由真菌生物学、免疫学和宿主领域的顶尖科学家进行的实验室技能培训 反应和抗真菌药物开发。这些技能对于培养和促进训练有素的 面对真菌对人类福祉构成的日益严重的威胁，MOMY的目标 为期2周的课程是提供技术，程序和 分子真菌学的概念，通过与真菌和真菌动物模型的直接经验， 疾病重要的是，MOMY提供重要的职业指导和专业发展机会 在整个过程中，所有参与者。我们实现我们的目标，部分是通过参与一个 多样化和忠诚的教师谁是来自真菌学社区的领先专家。我们的具体目标 （1）深入讲授现代分子医学真菌学的基本技能; (2)提供基于分子生物学前沿方法和概念的指导研究机会 医学真菌学;以及（3）为学员提供职业指导，包括专业发展 咨询、科学道德培训和发展终身专业指导网络。总的来说， MOMY在成功实现这些目标以推进NIH使命和推进我们的 能够提出，探索和回答有关真菌对人类健康影响的关键问题。的 鉴于真菌对人类健康影响的范围和发生率不断增加， 人类和快速的研究技术和概念的进步发生在我们的领域。