Molecular Mycology: Current Approaches to Fungal Pathogenesis (MoMy) Training Course

分子真菌学：真菌发病机制的最新方法 (MoMy) 培训课程

• 批准号: 10461947
• 负责人: David R Andes
• 金额: $ 10.81万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-04 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461947
• 关键词: Achievement; Address; Affect; Animal Model; Anniversary; Antifungal Agents; Authorship; Biological; Biology; Biomedical Research; Clinical; Collaborations; Communities; Data; Development; Development Plans; Disease; Education; Ethics; Faculty; Foundations; Funding; Fungi Model; Future; Grant; Health; Human; Immersion; Immune; Immune response; Immunology; Incidence; Instruction; Knowledge; Laboratories; Medical; Mentors; Methods; Microscopy; Mission; Molecular; Molecular Biology; Morbidity - disease rate; Mycoses; National Institute of Allergy and Infectious Disease; Nursing Faculty; Paper; Participant; Pathogenesis; Personal Satisfaction; Pharmaceutical Preparations; Physicians; Positioning Attribute; Procedures; Publishing; Recording of previous events; Research; Research Personnel; Role; Science; Scientist; Students; Surveys; Techniques; The science of Mycology; Therapeutic; Training; Underrepresented Minority; United States National Institutes of Health; Wood material; Writing; base; career; data sharing; drug development; experience; experimental study; faculty mentor; faculty research; fungus; hands-on learning; meetings; microbiome components; mortality; novel; pathogen; patient population; peer; programs; response; responsible research conduct; skill acquisition; skills; skills training; tenure track

PROJECT SUMMARY The purpose of this application is to support the Molecular Mycology and Pathogenesis education program (MOMY) at the Marine Biological Laboratory (MBL) in Woods Hole, MA. MOMY is now approaching its 25th anniversary at the MBL. Over the course’s history it has provided pivotal training for a scientific workforce to meet the world’s biomedical research needs related to the growing incidence of, and limited therapeutic options for, human fungal infections. Simply put, there is an urgent need for new research with human fungal infections given the rapid advances in immune modulating medical therapies that often result in opportunistic fungal infections. MOMY has addressed both the significant impact of fungi on morbidity and mortality in immune compromised patient populations, as well as the role of fungi as microbiome components that affect health and disease. Our intensive and immersive MOMY program provides trainees hands-on laboratory skill training by leading scientists in the fields of fungal biology, immunology & host response, and antifungal drug development. These skills are critical to develop and promote a well-trained workforce in the face of the growing threat posed by fungi to human well-being. MOMY’s objective during the 2 week course is to provide foundational knowledge and training in the techniques, procedures, and concepts in molecular mycology through direct experiences working with fungi and animal models of fungal disease. Importantly, MOMY provides critical career mentoring and professional development opportunities throughout the course to all participants. We achieve our objective in part through the participation of a diverse and committed faculty who are leading experts from the mycology community. Our specifics aims are: (1) To provide in-depth instruction on fundamental contemporary skills in molecular medical mycology; (2) To provide mentored research opportunities based on cutting edge methods and concepts in molecular medical mycology; and (3) To provide trainees with career mentoring, including professional development advice, science ethics training, and development of a lifelong professional mentoring network. Overall, MOMY has a long history of successfully meeting these aims to advance the NIH Mission and advance our ability to ask, explore, and answer critical questions related to the impact of fungi on human health. The course remains of utmost significance given the increasing scope and incidence of fungi’s impact on humanity and the rapid research technological and conceptual advances occurring in our field.

项目概要 此应用程序的目的是支持分子真菌学和发病机制教育计划 （MOMY）在马萨诸塞州伍兹霍尔的海洋生物实验室（MBL）。 MOMY 即将迎来 25 岁生日 MBL 周年纪念日。在该课程的历史上，它为科学工作者提供了关键的培训 满足与日益增长的发病率和有限的治疗相关的世界生物医学研究需求 人类真菌感染的选择。简而言之，迫切需要针对人类进行新的研究。 鉴于免疫调节医学疗法的快速进步，真菌感染通常会导致 机会性真菌感染。 MOMY 解决了真菌对发病率的重大影响和 免疫受损患者群体的死亡率，以及真菌作为微生物组的作用 影响健康和疾病的成分。我们密集且身临其境的 MOMY 项目为学员提供 由真菌生物学、免疫学和宿主领域的顶尖科学家提供的实验室实践技能培训 反应和抗真菌药物开发。这些技能对于培养和促进训练有素的人才至关重要 劳动力面临真菌对人类福祉构成的日益严重的威胁。 MOMY 期间的目标 为期两周的课程旨在提供技术、程序和技术方面的基础知识和培训 通过直接使用真菌和真菌动物模型的经验了解分子真菌学的概念 疾病。重要的是，MOMY 提供重要的职业指导和专业发展机会 在整个课程中向所有参与者传达。我们部分通过以下人员的参与来实现我们的目标： 多元化且忠诚的教师队伍，他们都是真菌学界的顶尖专家。我们的具体目标 是：（1）提供分子医学真菌学基本现代技能的深入指导； (2) 提供基于分子生物学前沿方法和概念的指导研究机会 医学真菌学； (3) 为学员​​提供职业指导，包括专业发展 建议、科学道德培训以及建立终身专业指导网络。全面的， MOMY 长期以来一直成功实现这些目标，以推进 NIH 使命并推进我们的使命 能够提出、探索和回答与真菌对人类健康影响相关的关键问题。这 鉴于真菌影响的范围和发生率不断增加，这一过程仍然至关重要 人类以及我们领域中发生的快速研究技术和概念进步。