UV to blue neuronal phototransduction mechanisms
紫外到蓝色神经元光转导机制
基本信息
- 批准号:10621560
- 负责人:
- 金额:$ 52.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-04-01 至 2028-03-31
- 项目状态:未结题
- 来源:
- 关键词:AedesAgricultureAnopheles gambiaeArousalBehaviorBehavior ControlBehavioralBiologicalBiological AssayBrainCellsColor VisionsComplexCryingCulicidaeCustomDevicesDisease VectorsDrosophila genusEconomicsElectrophysiology (science)EnvironmentEyeFlavin-Adenine DinucleotideFriendsG-Protein Signaling PathwayGeneticGoalsHealthHumanImageInsect ControlInsectaLightMeasuresMediatingMolecular GeneticsMosquito ControlNeuronsOpsinOutputOxidation-ReductionPesticidesPhototransductionPhysiologicalResearchRhodopsinSignal TransductionSystemTimeVector-transmitted infectious diseaseVisionVisualbehavioral responsechromophorecombatcryptochromedesignfightingflyhazardhuman diseasein vivoinnovationinstrumentationnovelresponsevector-borne
项目摘要
Many insects pose major health and economic hazards to humans as common disease vectors and
agricultural pests. Almost all of our present understanding of insect phototransduction is based on opsin-based
photoreception in eyes that mediate image forming vision. My lab has recently discovered two additional
phototransduction mechanisms in Drosophila. Cryptochrome (CRY) and Rhodopsin 7 (Rh7) expressed in central
brain neurons mediate rapid onset sustained electrophysiological responses in these neurons. CRY and Rh7
light signaling underlie a novel form of non-image forming vision that strongly modulates complex time-of-day
dependent insect behavioral responses to light, including avoidance/attraction behavioral choice between light
and shade and light evoked arousal. While CRY's mechanism of action is due to light evoked redox state
changes of its flavin adenine dinucleotide (FAD) chromophore and Rh7's mechanism of action is through a G-
protein signaling pathway, they physiologically interact and may form the basis of a true color vision system for
non-image forming vision that discerns specific light spectra. We have extended our study of non-image forming
vision to harmful nocturnal Anopheles gambiae and diurnal Aedes aegypti mosquitoes and find that CRY1s
mediate very distinct time-of-day dependent species specific behavioral light responses in these mosquitp-o
important disease vectors. Remarkably, nocturnal and diurnal mosquito CRY1s confer mosquito species specific
behavioral effects when expressed in all CRY expressing cells in a cry-null Drosophila genetic background and
nocturnal mosquito CRY1 is significantly more light sensitive than diurnal mosquito CRY1 measured by multiple
behavioral and electrophysiological assays. We will determine the detailed mechanisms that confer species
specific physiological and behavioral light responses for flies and mosquitoes and other insects using a highly
sensitive electrophysiological assay that we have developed that will allow us to accurately measure redox state
changes and biological outputs for light sensitive CRYs and functional interactions between CRYs and Rh7, in
combination with behavioral analysis. Our custom designed instrumentation allows us to examine CRY
spectrally driven redox state changes in vivo. Present insect control strategies rely heavily on highly toxic
pesticides. A far more environmentally friendly alternative is to make use of light-based behavioral manipulation
of insects in a species specific fashion to attract harmful insect species to traps or to repel them away from
human habitation. The goal of our research to form a rational basis for designing innovative new LED devices
for species-specific harmful insect control in the ongoing fight against vector-borne diseases.
许多昆虫作为常见的疾病媒介,对人类的健康和经济构成重大危害
项目成果
期刊论文数量(20)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine.
- DOI:10.1038/s41398-021-01255-4
- 发表时间:2021-02-24
- 期刊:
- 影响因子:6.8
- 作者:Grieco SF;Qiao X;Johnston KG;Chen L;Nelson RR;Lai C;Holmes TC;Xu X
- 通讯作者:Xu X
Erythrocyte-brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo.
- DOI:10.1186/s12974-023-02932-5
- 发表时间:2023-11-15
- 期刊:
- 影响因子:9.3
- 作者:
- 通讯作者:
Weekend Light Shifts Evoke Persistent Drosophila Circadian Neural Network Desynchrony.
- DOI:10.1523/jneurosci.3074-19.2021
- 发表时间:2021-06-16
- 期刊:
- 影响因子:0
- 作者:Nave C;Roberts L;Hwu P;Estrella JD;Vo TC;Nguyen TH;Bui TT;Rindner DJ;Pervolarakis N;Shaw PJ;Leise TL;Holmes TC
- 通讯作者:Holmes TC
Probing neural circuit mechanisms in Alzheimer's disease using novel technologies.
- DOI:10.1038/s41380-023-02018-x
- 发表时间:2023-10
- 期刊:
- 影响因子:11
- 作者:Grieco, Steven F.;Holmes, Todd C.;Xu, Xiangmin
- 通讯作者:Xu, Xiangmin
Mosquito cryptochromes expressed in Drosophila confer species-specific behavioral light responses.
- DOI:10.1016/j.cub.2022.07.021
- 发表时间:2022-09-12
- 期刊:
- 影响因子:9.2
- 作者:Au, David D.;Foden, Alexander J.;Park, Soo Jee;Nguyen, Thanh H.;Liu, Jenny C.;Tran, Mary D.;Jaime, Olga G.;Yu, Zhaoxia;Holmes, Todd C.
- 通讯作者:Holmes, Todd C.
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Todd C Holmes其他文献
Todd C Holmes的其他文献
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{{ truncateString('Todd C Holmes', 18)}}的其他基金
UV to blue neuronal phototransduction mechanisms
紫外到蓝色神经元光转导机制
- 批准号:
10374057 - 财政年份:2018
- 资助金额:
$ 52.05万 - 项目类别:
UV to blue neuronal phototransduction mechanisms
紫外到蓝色神经元光转导机制
- 批准号:
10388927 - 财政年份:2018
- 资助金额:
$ 52.05万 - 项目类别:
UV to blue neuronal phototransduction mechanisms
紫外到蓝色神经元光转导机制
- 批准号:
9900018 - 财政年份:2018
- 资助金额:
$ 52.05万 - 项目类别:
Mechanism of cryptochrome-mediated photo transduction
隐花色素介导的光转导机制
- 批准号:
8502106 - 财政年份:2013
- 资助金额:
$ 52.05万 - 项目类别:
Mechanism of cryptochrome-mediated photo transduction
隐花色素介导的光转导机制
- 批准号:
8706189 - 财政年份:2013
- 资助金额:
$ 52.05万 - 项目类别:
Mechanism of cryptochrome-mediated photo transduction
隐花色素介导的光转导机制
- 批准号:
9090139 - 财政年份:2013
- 资助金额:
$ 52.05万 - 项目类别:
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