The PAS Sensor Family and Human Health
PAS 传感器系列与人类健康
基本信息
- 批准号:10621257
- 负责人:
- 金额:$ 83.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-15 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:Aryl Hydrocarbon ReceptorAtmosphereBehaviorBiochemicalChemical ExposureDiabetes MellitusDiseaseEnvironmentFamilyFreedomGenesGeneticHealthHumanInfertilityInflammatory Bowel DiseasesInterventionLigandsLightMalignant NeoplasmsObesityOxygenPathway interactionsPhysiologyPlayPopulationPrevention strategyProtein FamilyProteinsPublic HealthReagentResearch Project GrantsRoleScientistSignal TransductionTherapeuticTimeVisioncircadiancofactordesignexperiencehuman morbidityinsightmicrobiomeprogramsresponsesensor
项目摘要
PROJECT SUMMARY
This R35 proposal is designed to consolidate two R01 programs, ES005703 and ES020668 into one
program with an emphasis on understanding how environment influences human health through the PAS
sensor family of proteins. Our approach is to use a highly experienced team, a broad spectrum of
biochemical and genetic reagents, a transdisciplinary approach, and the expertise of an array of
collaborators and clinician scientists to define the roles that PAS sensors play in environmentally influenced
disease states such as cancer, infertility, obesity, diabetes and inflammatory bowel disease. Our
overarching idea is that PAS sensors, and their related environmental signals, are impinging on almost
every aspect of human health through their capacity as sensors of circadian time, oxygen status, chemical
exposure and microbiome changes. We propose that by understanding these pathways, we can not only
identify important gene by environment, and environment by environment interactions, but that we can use
this information to develop intervention strategies in numerous environmental scenarios likely to be causing
human morbidity. Our vision is to understand these pathways through the prism of the Ah receptor (AHR)
and through the overarching idea that these pathways are in fact interacting through shared partners,
cofactors or ligands. We propose that the insights gained from the R35 will ultimately be useful in
intervention strategies to manipulate these pathways via therapeutics or to guide/modify human behavior or
the human environment in a manner that is most beneficial to sensitive populations. Over the next eight
years, this consolidated R35 should give us the freedom and power to make considerable advances in our
understanding of PAS sensors and how they influence human health.
项目摘要
本R35提案旨在将两个R 01项目ES 005703和ES 020668合并为一个项目
一个程序,重点是了解环境如何影响人类健康,通过PAS
传感器家族的蛋白质。我们的方法是使用一个经验丰富的团队,广泛的
生物化学和基因试剂,跨学科的方法,以及一系列的专业知识,
合作者和临床科学家来定义PAS传感器在环境影响中发挥的作用,
疾病状态,如癌症、不孕症、肥胖症、糖尿病和炎症性肠病。我们
总体思路是,PAS传感器及其相关的环境信号,几乎
人类健康的每一个方面,通过他们的能力作为传感器的昼夜时间,氧气状态,化学
暴露和微生物组变化。我们认为,通过了解这些途径,我们不仅可以
通过环境以及环境与环境相互作用来识别重要基因,但是我们可以利用
这一信息,以制定干预战略,在许多环境的情况下,可能会导致
人类发病率。我们的愿景是通过Ah受体(AHR)的棱镜来了解这些途径
通过这些途径实际上是通过共同的伙伴相互作用的总体思想,
辅因子或配体。我们认为,从R35中获得的见解最终将有助于
干预策略,通过治疗或指导/改变人类行为来操纵这些途径,
以最有利于敏感人群的方式保护人类环境。在未来八
多年来,这一合并的R35应该给我们的自由和权力,使我们在我们的
了解PAS传感器以及它们如何影响人类健康。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CHRISTOPHER A BRADFIELD其他文献
CHRISTOPHER A BRADFIELD的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CHRISTOPHER A BRADFIELD', 18)}}的其他基金
Identification and Characterization of the Mouse PPCD1 Gene
小鼠 PPCD1 基因的鉴定和表征
- 批准号:
8309049 - 财政年份:2011
- 资助金额:
$ 83.57万 - 项目类别:
Summer Research Experience for Minority Undergraduates
少数民族本科生暑期研究经历
- 批准号:
8660695 - 财政年份:2011
- 资助金额:
$ 83.57万 - 项目类别:
Molecular and Environmental Toxicology Summer Research Opportunities Program (MET-SROP)
分子与环境毒理学夏季研究机会计划(MET-SROP)
- 批准号:
9474621 - 财政年份:2011
- 资助金额:
$ 83.57万 - 项目类别:
Identification and Characterization of the Mouse PPCD1 Gene
小鼠 PPCD1 基因的鉴定和表征
- 批准号:
8700411 - 财政年份:2011
- 资助金额:
$ 83.57万 - 项目类别:
相似国自然基金
图们江流域农村生活污水处理中Atmosphere-Exposed Biofilm的净化机理及动力学研究
- 批准号:51269032
- 批准年份:2012
- 资助金额:49.0 万元
- 项目类别:地区科学基金项目
相似海外基金
Behavior of gas phase and particulate organic nitrates in the atmosphere, centering on the transboundary pollution from East Asia
以东亚跨界污染为中心的大气中气相和颗粒有机硝酸盐的行为
- 批准号:
17K00525 - 财政年份:2017
- 资助金额:
$ 83.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
HIGH-PERFORMANCE NEAR-DRY MACHINING BY TRIBOLOGICAL BEHAVIOR INVESTIGATION OF OXYGEN-INCLUDING COMPOUNDS AND ATMOSPHERE CONTROL
通过含氧化合物的摩擦学行为研究和气氛控制进行高性能近干加工
- 批准号:
22560144 - 财政年份:2010
- 资助金额:
$ 83.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Effect of atmospheric humic-like substances on the behavior of hazardous organic pollutants and heavy metals in the atmosphere
大气类腐殖质物质对大气中有害有机污染物和重金属行为的影响
- 批准号:
16310029 - 财政年份:2004
- 资助金额:
$ 83.57万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Titan's Atmosphere in the Pre-Cassini Decade: Establishing Long-Term Behavior from HST and Ground-Based/AO Observations
卡西尼号之前十年的土卫六大气层:根据 HST 和地面/AO 观测建立长期行为
- 批准号:
0206390 - 财政年份:2002
- 资助金额:
$ 83.57万 - 项目类别:
Standard Grant
EFFECT OF ATMOSPHERE ON THE FATIGUE BEHAVIOR AND ITS STATISTICAL CHARACTERISTICS OF Al ALLOY SPECIMENS
气氛对铝合金试件疲劳行为及其统计特性的影响
- 批准号:
09650108 - 财政年份:1997
- 资助金额:
$ 83.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Behavior and Reactivity of Reactive Species in the Atmosphere
大气中活性物质的行为和反应性
- 批准号:
08680452 - 财政年份:1996
- 资助金额:
$ 83.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Behavior of N2O in the atmosphere and making the global budget using nitrogen and oxygen isotope systematics
N2O 在大气中的行为以及利用氮氧同位素系统学制定全球预算
- 批准号:
07454136 - 财政年份:1995
- 资助金额:
$ 83.57万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Vaporization Behavior of Tritium Breeding Candidate Materials in Reducing Atmosphere at High Temperatures
氚增殖候选材料在高温还原气氛中的汽化行为
- 批准号:
03808027 - 财政年份:1991
- 资助金额:
$ 83.57万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Particulate Organic Compounds and Their Behavior in Urban and Remote Atmosphere
颗粒有机化合物及其在城市和偏远大气中的行为
- 批准号:
01470041 - 财政年份:1989
- 资助金额:
$ 83.57万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
A set up of an atmosphere-controlled furnace with stirring device, and effect of stirring on the crystallization behavior of basaltic melts.
带搅拌装置的气氛控制炉的设置以及搅拌对玄武岩熔体结晶行为的影响。
- 批准号:
01840030 - 财政年份:1989
- 资助金额:
$ 83.57万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research