Training Program at the Chemistry Biology Interface

化学生物学接口的培训计划

• 批准号: 10623229
• 负责人: Paul Hergenrother
• 金额: $ 63.66万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623229
• 关键词: Biology; Chemistry; Training Programs

PROJECT SUMMARY A fuller understanding of living systems at the molecular level has led to revolutionary changes in the fields of chemistry and biology and has made the boundary between these traditional disciplines less defined. To leverage the exciting scientific advances at the chemistry-biology interface and to be poised to make major contributions to biology and medicine, chemists and biologists must speak a common scientific language. The Chemistry-Biology Interface Training Program (CBI-TP) at the University of Illinois, Urbana-Champaign (UIUC) will offer an environment in which chemists and biologists can acquire interdisciplinary training that enables them to learn a common language and to acquire a shared set of research skills without compromising their ability to acquire deep discipline-specific knowledge in specialized areas of chemistry or biology. Through shared experiences in the classroom and in the laboratory, the CBI-TP is intended to enhance the studies of graduate students enrolled in six departments at UIUC: Chemistry, Chemical and Biomolecular Engineering, Biochemistry, Microbiology, Cell and Developmental Biology, and Molecular and Integrative Physiology. Each year, 12 trainees will be supported by the NIH, in addition to 5 matching positions supported by UIUC. Highlights of the program include courses specifically developed for the CBI-TP (including a hands-on laboratory course), first year laboratory rotations, strong training in rigor and reproducibility, an opportunity for internships, a highly diverse student body, and extremely strong institutional support. The program also offers unique opportunities for professional and career development including (i) a student-run seminar program during which trainees invite, host, and discuss their research with outside seminar speakers, (ii) creation of Individual Development Plans (IDPs) for which trainees are required to research at least three career options, join a professional organization, and attend at least one career-related workshop, (iii) options to earn relevant certifications such as the Certificate in Entrepreneurship and Management, and/or take part in internships, and (iv) participation in multiple career development activities, intended to better prepare graduate students at the chemistry-biology interface for interesting and challenging career paths and opportunities. No matter their ultimate career goals, the CBI-TP platform at UIUC, running for 14 years now, has no equivalent elsewhere on our campus. The goal of the CBI-TP is to arm trainees with the breadth of education necessary to bridge the gap between the chemical and biological sciences. The trainees have been, and will continue to be, among those scientists making significant contributions to biomedicine as participants in and leaders of multidisciplinary teams in industry, government, or academia.

项目摘要 在分子水平上对生命系统的更全面的理解导致了以下领域的革命性变化： 化学和生物学之间的界限变得模糊不清。到 利用化学-生物学界面上令人兴奋的科学进步，并准备使主要 为了对生物学和医学作出贡献，化学家和生物学家必须讲一种共同的科学语言。的 伊利诺伊大学厄巴纳-香槟分校（UIUC）的化学-生物学界面培训计划（CBI-TP） 将提供一个环境，化学家和生物学家可以获得跨学科的培训， 他们学习一种共同的语言，并获得一套共同的研究技能，而不损害他们的 在化学或生物学的专业领域获得深入的学科特定知识的能力。通过 在课堂和实验室中分享经验，CBI-TP旨在加强以下研究： 研究生就读于六个部门在UIUC：化学，化学和生物分子工程， 生物化学，微生物学，细胞和发育生物学，分子和综合生理学。每个 今年，12名学员将由NIH支持，除了5个匹配的职位由UIUC支持。 该计划的亮点包括专门为CBI-TP开发的课程（包括实践 实验室课程），第一年的实验室轮换，严格性和再现性的强有力的培训， 实习，一个高度多样化的学生团体，和非常强大的机构支持。该方案还提供 专业和职业发展的独特机会，包括（i）学生运行的研讨会计划 在此期间，学员邀请，主持，并讨论他们的研究与外部研讨会发言人，（二）创建 个人发展计划，要求受训者研究至少三种职业选择， 加入一个专业组织，并参加至少一个与职业相关的研讨会，（iii）获得相关职业的选择 认证，如创业和管理证书，和/或参加实习，以及 (iv)参加多种职业发展活动，旨在更好地准备研究生在 化学-生物学接口，提供有趣和具有挑战性的职业道路和机会。不管他们的 最终的职业目标，在UIUC的CBI-TP平台，运行了14年，没有相当于其他地方 我们的校园CBI-TP的目标是为学员提供必要的教育广度， 化学和生物科学之间的差距。学员一直是，并将继续是， 那些对生物医学做出重大贡献的科学家作为参与者和领导者， 行业、政府或学术界的多学科团队。

项目成果

Development of Photoacoustic Probes for in Vivo Molecular Imaging.

• DOI: 10.1021/acs.biochem.7b00888
• 发表时间: 2018-01-16
• 期刊: Biochemistry
• 影响因子: 2.9
• 作者: Reinhardt CJ;Chan J
• 通讯作者: Chan J

Advances in Activity-Based Sensing Probes for Isoform-Selective Imaging of Enzymatic Activity.

• DOI: 10.1002/anie.202003687
• 发表时间: 2021-03-01
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Gardner SH;Reinhardt CJ;Chan J
• 通讯作者: Chan J

Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations.

• DOI: 10.1002/anie.201911896
• 发表时间: 2019-12
• 期刊: Angewandte Chemie
• 作者: Riley L. Svec;P. Hergenrother

Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation.

• DOI: 10.1016/j.chembiol.2018.05.008
• 发表时间: 2018-08-16
• 期刊: Cell chemical biology
• 影响因子: 8.6
• 作者: Peh J;Boudreau MW;Smith HM;Hergenrother PJ
• 通讯作者: Hergenrother PJ

A General Approach to Convert Hemicyanine Dyes into Highly Optimized Photoacoustic Scaffolds for Analyte Sensing*.

• DOI: 10.1002/anie.202105905
• 发表时间: 2021-08-16
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Gardner SH;Brady CJ;Keeton C;Yadav AK;Mallojjala SC;Lucero MY;Su S;Yu Z;Hirschi JS;Mirica LM;Chan J
• 通讯作者: Chan J