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Laboratory for Early Psychosis Research (LEAP)

早期精神病研究实验室 (LEAP)

基本信息

批准号：
10623802
负责人：
MIGUEL HERNAN
金额：
$ 213.87万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-15 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10623802
关键词：
Address Adverse effects Advocate Antipsychotic Agents Benchmarking Binding Caring Clinic Clinical Data Clinical Research Clinical Trials Cognitive remediation Collaborations Comparative Effectiveness Research Complement Coordinated Specialty Care Country Data Data Collection Data Science Data Set Data Sources Dedications Development Discipline Disease Economics Effectiveness Electronic Health Record Epidemiology Equity Evolution Face Faculty Family Funding Future Goals Health Policy Health system Healthcare Systems Heterogeneity Infrastructure Injectable Inpatients International Intervention Laboratories Learning Machine Learning Massachusetts Mental Health Methods Modernization National Institute of Mental Health North America Operations Research Patient Care Patients Pharmacotherapy Pilot Projects Policies Policy Maker Provider Psychiatry Psychotic Disorders Publishing Randomized, Controlled Trials Registries Research Research Design Research Methodology Role Schizophrenia Science Scientist Site Source Standardization Strategic Planning Sum System Techniques Testing Training Work analytical method care systems clinical care clinical predictors data harmonization data registry data standards design digital diverse data early psychosis electronic health data first episode psychosis improved innovation interdisciplinary collaboration knowledge base multiple data types outreach patient engagement peer randomized, clinical trials standard of care statistics treatment effect trial design

项目摘要

1. Abstract We propose to continue our existing NIMH P50 ALACRITY Center (Laboratory for Early Psychosis or LEAP Center). Although coordinated specialty care (CSC) is standard of care for patients with first episode psychosis (FEP), there remain gaps in our knowledge base regarding selection and deployment of treatments. The LEAP Center has been addressing these gaps through development of a statewide CSC clinic system in Massachusetts, standardized data collection and participation in the EPINET consortium, and adapting methods developed outside of mental health. In the first LEAP Center period, we have generated strong interdisciplinary collaborations between clinicians, policy makers/regulators, and stakeholders, and FEP experts from across the country plus scientific experts from outside of mental health, e.g., in data science, machine learning, epidemiology, and health policy. In the next period, we will leverage these collaborations to conduct a randomized clinical trial and to access diverse data sources to examine the role of specific treatment interventions in FEP. We also will apply and develop modern methods for clinical prediction and comparative effectiveness research (CER) for FEP research. We have three overall Center aims: 1) Collaborations; 2) Clinical research; and 3) Prediction and CER methods. The Center will include four complementary projects: 1) Project 1 is a “signature” project to conduct a cluster randomized clinical trial of enhanced CSC. 2) Project 2 will apply causal inference techniques on FEP-CAUSAL, an international data platform; 3) Project 3 will leverage EPINET national registry data to estimate the effect of treatment exposures studied in Project 1; 4) Project 4 will compare CSC care with non-CSC care at the state level using both electronic health record and statewide administrative datasets. The Administrative Core and Methods Core bind these projects and the multiple types of data (i.e., experimental data and observational data from electronic health records, national registries, or administrative datasets) and analytic approaches together. We have a group of Scientific Advisors, Center Faculty from diverse scientific disciplines (e.g., those that historically have had limited mental health research exposure), and Stakeholders (e.g., policy makers, organizational leaders, and patient and family advocates) who will be deeply involved in the Center from design to dissemination. The overall goal is to continue the evolution towards a state-wide learning health system for early psychosis which started in the first LEAP Center period and to continue to support NIMH-sponsored EPINET learning health system consortium.

1. 摘要我们建议继续现有的 NIMH P50 ALACRITY 中心（早期精神病实验室或 LEAP 中心）。尽管协调专科护理 (CSC) 是首发精神病患者的标准护理（FEP），我们在治疗选择和部署方面的知识库仍然存在差距。飞跃该中心一直在通过开发全州 CSC 诊所系统来解决这些差距马萨诸塞州，标准化数据收集和参与 EPINET 联盟，并适应在心理健康之外开发的方法。在第一个 LEAP 中心期间，我们产生了强大的临床医生、政策制定者/监管者和利益相关者以及 FEP 之间的跨学科合作来自全国各地的专家以及心理健康领域以外的科学专家，例如数据科学领域的专家，机器学习、流行病学和卫生政策。在接下来的一段时间内，我们将利用这些合作来进行随机临床试验并访问不同的数据源以检查特定治疗的作用 FEP 的干预。我们还将应用和开发现代方法进行临床预测和比较 FEP 研究的有效性研究（CER）。我们中心有三个总体目标：1）合作； 2）临床研究； 3) 预测和 CER 方法。该中心将包括四个补充项目：1) 项目1是一个“标志性”项目，旨在进行增强型CSC的整群随机临床试验。 2）项目2 将在国际数据平台FEP-CAUSAL上应用因果推理技术； 3) 项目 3 将利用 EPINET 国家登记数据来估计项目 1 中研究的治疗暴露的影响； 4）项目 4 将使用电子健康记录和全州行政数据集。管理核心和方法核心将这些项目和多种类型的数据（即来自电子健康记录的实验数据和观察数据、国家登记处或管理数据集）和分析方法一起。我们拥有一批科学的顾问、来自不同科学学科的中心教员（例如，那些历史上智力有限的教员）健康研究暴露）和利益相关者（例如政策制定者、组织领导者以及患者和家庭倡导者）将深入参与该中心从设计到传播的整个过程。总体目标是继续向全州范围内的早期精神病学习健康系统发展，该系统始于第一年 LEAP中心期间继续支持NIMH赞助的EPINET学习健康系统联盟。

项目成果

期刊论文数量（38）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Pathways Through Early Psychosis Care for U.S. Youths From Ethnically and Racially Minoritized Groups: A Systematic Review.

DOI：
10.1176/appi.ps.20220121
发表时间：
2023-08-01
期刊：
PSYCHIATRIC SERVICES
影响因子：
3.8
作者：
Myers, Neely;Hutnyan, Matthew;Daley, Tamara C.;Bello, Iruma;Chacon, Marne;Currie, Ariel;Davis, Beshaun J.;Dixon, Lisa B.;George, Preethy E.;Giannicchi, Anna;Kwashie, Anita N.;McCormick, Katie A.;Meyer-Kalos, Piper;Nagendra, Arundati;Nayar, Swati;Sarpal, Deepak K.;Sepahpour, Tiana Y.;Shapiro, Daniel I.;Taylor-Zoghby, Jessica
通讯作者：
Taylor-Zoghby, Jessica

Economic analysis of early intervention for autistic children: findings from four case studies in England, Ireland, Italy, and Spain.

DOI：
10.1192/j.eurpsy.2023.2449
发表时间：
2023-09-21
期刊：
EUROPEAN PSYCHIATRY
影响因子：
7.8
作者：
Tinelli, Michela;Roddy, Aine;Knapp, Martin;Arango, Celso;Mendez, Maria Andreina;Cusack, James;Murphy, Declan;Canitano, Roberto;Oakley, Bethany;Quoidbach, Vinciane
通讯作者：
Quoidbach, Vinciane

Pilot development and feasibility of telehealth Community Reinforcement and Family Training (CRAFT) for early psychosis and substance use.

DOI：
10.1016/j.psychres.2022.114804
发表时间：
2022-11
期刊：
PSYCHIATRY RESEARCH
影响因子：
11.3
作者：
McCarthy, Julie M.;Wood, Andrea J.;Shinners, M. Grace;Heinrich, Hadley;Weiss, Roger D.;Mueser, Kim T.;Meyers, Robert J.;Carol, Emily E.;Hudson, James I.;Ongur, Dost
通讯作者：
Ongur, Dost

The unfulfilled promise of equitable first episode care for Black-Americans: A way forward.