LEAP Methods Core
LEAP Methods Core
批准号:
10623804
负责人:
MIGUEL HERNAN
金额:
$45.69万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
未结题
起止时间:
2019-05-15 至 2028-06-30
关键词:
AddressAlgorithmsAreaCaringCharacteristicsClassificationClinicClinicalClinical DataClinical ManagementCollaborationsCollectionCommunitiesComparative Effectiveness ResearchDataData AnalysesData CollectionData SecurityData SetData SourcesDatabasesDecision MakingDevelopmentDisciplineElectronic Health RecordEmpirical ResearchEnsureEpidemiologyFundingGenerationsHealth InsuranceHealth PolicyHealth systemHealthcareIncubatorsInfrastructureKnowledgeLaboratoriesLeadLinkMachine LearningMassachusettsMedicineMental HealthMethodologyMethodsModelingNational Institute of Mental HealthOutcomePatientsPopulationProceduresProspective cohortPsychiatryPublic Health SchoolsRandomized, Controlled TrialsResearchResearch DesignResearch MethodologyResearch PersonnelResearch Project GrantsResourcesSecureServicesTechniquesTechnologyThinnessTimeTrainingTranslational ResearchWorkanalytical methodclinical databaseclinical predictorscompare effectivenesscomputerized toolscomputing resourcesdata integrationdata managementdata repositorydata resourcedata submissiondiverse dataearly psychosiseffective interventionfirst episode psychosishigh dimensionalityimprovedinnovationinsurance claimslarge datasetslongitudinal datasetmachine learning algorithmnovelrandomized trialresponsesocioeconomicsstatisticstheories
中文摘要
1.摘要
LEAP中心的核心方法将继续在集成信息的数据平台上工作
对首发精神病(FEP)患者进行不同程度的护理,并将发展成
将允许中心调查人员访问和分析综合数据库的计算工具。
具体地说,方法核心将提供应用最先进技术的方法专业知识
用于临床预测和尖端因果推理应用的机器学习算法
比较有效性研究的技术。首先,方法核心将提供数据库
安全存储、协调、链接、管理和分析高维数据库的基础设施
被中心调查人员利用。这些数据库包括详细的临床、人口学、社会经济学
每个FEP患者的信息,加上随机对照试验数据、电子健康记录和保险
索赔,以及关于诊所特征和提供的服务的纵向数据集。其中许多数据源
从未被用于精神健康研究,无论是独立的还是共同的。我们将创造唯一的
总部设在美国的财团接近1000名FEP患者。第二,方法核心将确保
临床预测和比较有效性研究的最新进展可以应用于
FEP患者数据库,并将成为方法学研究的孵化器,以应对
中心项目的要求。它将作为专家之间协同合作的平台
在几个学科--精神病学、统计学、流行病学和卫生政策--谁将参与高影响力
改善FEP患者临床结局的研究。我们的项目还提供了一个潜在的数据模型
跨多个NIMH Aacrity P50中心进行整合和专业知识共享。总而言之,这些方法
核心将在所有项目中支持数据分析活动,并将传播方法学
在精神卫生研究人员社区中取得了进展,因此将作为国家
促进使用中心调查人员之外的创新方法的资源。
英文摘要
1. Abstract
The Methods Core of the LEAP Center will continue to work on a data platform that integrates information
obtained at different levels of care of First Episode Psychosis (FEP) patients and will develop the
computational tools that will allow Center investigators to access and analyze the integrated databases.
Specifically, the Methods Core will provide the methodological expertise for the application of state-of-the-art
machine leaning algorithms for clinical prediction, and for the application of cutting-edge causal inference
techniques for comparative effectiveness research. First, the Methods Core will provide the database
infrastructure to securely store, harmonize, link, manage, and analyze the high-dimensional databases that will
be used by Center investigators. These databases include detailed clinical, demographic, socioeconomic
information for each FEP patient, plus randomized controlled trial data, electronic health records and insurance
claims, and longitudinal datasets on clinics characteristics and services offered. Many of these data sources
have never been used for mental health research, either independently or in concert. We will create the only
U.S.-based consortium approaching a thousand FEP patients. Second, the Methods Core will ensure that
recent advances in clinical prediction and comparative effectiveness research can be applied to large
databases of FEP patients and will be an incubator of methodological research in response to the
requirements of the Center projects. It will serve as a platform for a synergistic collaboration between experts
in several disciplines—psychiatry, statistics, epidemiology, and health policy—who will engage in high-impact
studies to improve the clinical outcomes of FEP patients. Our project also provides a potential model for data
consolidation and expertise sharing across multiple NIMH Alacrity P50 Centers. In summary, the Methods
Core will support the data analysis activities throughout all projects, and will disseminate methodological
advances amongst the community of mental health researchers and will therefore function as a national
resource that facilitates the use of innovative methods beyond the Center investigators.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Training Program in Comparative Effectiveness Research for Suicide Prevention
-
批准号:10403745
-
项目类别:
-
资助金额:$31.31万
-
财政年份:2022
-
负责人:MIGUEL HERNAN
-
依托单位:
Training Program in Comparative Effectiveness Research for Suicide Prevention
-
批准号:10657452
-
项目类别:
-
资助金额:$32.29万
-
财政年份:2022
-
负责人:MIGUEL HERNAN
-
依托单位:
Laboratory for Early Psychosis Research (LEAP)
-
批准号:10376216
-
项目类别:
-
资助金额:$163.46万
-
财政年份:2019
-
负责人:MIGUEL HERNAN
-
依托单位:
Laboratory for Early Psychosis Research (LEAP)
-
批准号:10559013
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2019
-
负责人:MIGUEL HERNAN
-
依托单位:
LEAP Methods Core
-
批准号:10376218
-
项目类别:
-
资助金额:$59.06万
-
财政年份:2019
-
负责人:MIGUEL HERNAN
-
依托单位:
Comparative effectiveness of pharmacologic strategies to treat first episode psychosis
-
批准号:10623806
-
项目类别:
-
资助金额:$17.13万
-
财政年份:2019
-
负责人:MIGUEL HERNAN
-
依托单位:
Laboratory for Early Psychosis Research (LEAP)
-
批准号:10001157
-
项目类别:
-
资助金额:$32.02万
-
财政年份:2019
-
负责人:MIGUEL HERNAN
-
依托单位:
Laboratory for Early Psychosis Research (LEAP)
-
批准号:10623802
-
项目类别:
-
资助金额:$213.87万
-
财政年份:2019
-
负责人:MIGUEL HERNAN
-
依托单位:
Long-term Impact of Fertility Treatment Study
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批准号:9361656
-
项目类别:
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资助金额:$66.52万
-
财政年份:2017
-
负责人:MIGUEL HERNAN
-
依托单位:
Long-term Impact of Fertility Treatment Study
-
批准号:9555923
-
项目类别:
-
资助金额:$56.32万
-
财政年份:2017
-
负责人:MIGUEL HERNAN
-
依托单位:
Long-term Impact of Fertility Treatment Study
-
批准号:10319620
-
项目类别:
-
资助金额:$54.07万
-
财政年份:2017
-
负责人:MIGUEL HERNAN
-
依托单位:
Long-term Impact of Fertility Treatment Study
-
批准号:9707617
-
项目类别:
-
资助金额:$55.29万
-
财政年份:2017
-
负责人:MIGUEL HERNAN
-
依托单位:
Dynamic strategies for the clinical management of HIV disease
-
批准号:8467226
-
项目类别:
-
资助金额:$53.52万
-
财政年份:2013
-
负责人:MIGUEL HERNAN
-
依托单位:
Dynamic strategies for the clinical management of HIV disease
-
批准号:8785027
-
项目类别:
-
资助金额:$55.26万
-
财政年份:2013
-
负责人:MIGUEL HERNAN
-
依托单位:
Dynamic strategies for the clinical management of HIV disease
-
批准号:8593226
-
项目类别:
-
资助金额:$56.39万
-
财政年份:2013
-
负责人:MIGUEL HERNAN
-
依托单位:
Dynamic Strategies for the clinical management of HIV disease
-
批准号:10404644
-
项目类别:
-
资助金额:$53.24万
-
财政年份:2012
-
负责人:MIGUEL HERNAN
-
依托单位:
Dynamic Strategies for the clinical management of HIV disease
-
批准号:10516960
-
项目类别:
-
资助金额:$63.56万
-
财政年份:2012
-
负责人:MIGUEL HERNAN
-
依托单位:
Dynamic Strategies for the clinical management of HIV disease
-
批准号:8498873
-
项目类别:
-
资助金额:$57.16万
-
财政年份:2012
-
负责人:MIGUEL HERNAN
-
依托单位:
Pooling HIV Cohorts to Inform Clinical Decision
-
批准号:8037942
-
项目类别:
-
资助金额:$16.08万
-
财政年份:2010
-
负责人:MIGUEL HERNAN
-
依托单位:
Pooling HIV Cohorts to Inform Clinical Decision
-
批准号:7336956
-
项目类别:
-
资助金额:$36.68万
-
财政年份:2007
-
负责人:MIGUEL HERNAN
-
依托单位:
海外基金