Howard University Clinical Research Network for Health Equity

霍华德大学健康公平临床研究网络

• 批准号: 10631693
• 负责人: Mark S. Johnson
• 金额: $ 98.4万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-26 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10631693
• 关键词: Address; Adoption; Advisory Committees; Affect; African American; African American population; Agreement; Chronic Disease; Clinical Data; Clinical Investigator; Clinical Management; Clinical Practice Guideline; Clinical Research; Clinical Trials; Complex; Computerized Medical Record; Data Analytics; Data Science; Development; Disease; Disease Management; District of Columbia; Epidemiology; Etiology; Faculty; Funding; Generations; Health Disparities Research; Health Professional; Information Technology; Infrastructure; Institution; Investigation; Knowledge; Low income; Methods; Minority Groups; Mission; Morbidity - disease rate; Outcome; Participant; Patient Care; Patient Recruitments; Patients; Physicians; Pilot Projects; Policies; Population; Preventive care; Preventive service; Principal Investigator; Process; Protocols documentation; Recommendation; Research; Research Activity; Research Personnel; Scientific Inquiry; System; Systems Analysis; Underrepresented Minority; United States; Universities; University Hospitals; clinical data repository; clinical development; combat; design; effectiveness evaluation; evidence base; experience; graduate medical education; health application; health data; health disparity; health disparity populations; health equity; health information technology; improve minority health; informatics infrastructure; inner city; innovation; knowledge translation; mHealth; minority health; minority health disparity; mortality; new technology; predictive modeling; research study; undergraduate student

Research Abstract African Americans experience significant disparities in chronic disease morbidity and mortality. Of note, eliminating health disparities requires significant improvement in chronic disease management, which is dependent on the provision and utilization of evidence-based preventive care. The provision of high-quality preventive services to the African Americans is hindered by several things including insufficient evidence which is a consequence of underrepresentation of minority populations in clinical research trials. In fact, United States Preventive Services Task Force (USPSTF) recommendation statements often cite underrepresentation of minorities in clinical trials as a research gap and limitation. This affects the development of clinical practice guidelines that meet the needs of minority populations when the epidemiology of a particular disease is different in minority populations. Not only is there an underrepresentation of minorities as study participants but there is equally severe underrepresentation of African Americans as clinical investigators, which is due in part to underrepresentation of African Americans in the clinical research workforce. Addressing these disparities requires complex systems analysis, development of innovative approaches, generation of scientific evidence, and effective knowledge dissemination. For over 150 years, Howard University has contributed significantly to the African American physician workforce through undergraduate and graduate medical education. In addition, Howard University has advanced minority health through robust research activities and comprehensive patient care to the residents of the District of Columbia and beyond. The adoption of Electronic Medical Record Systems by Howard University Hospital and Howard University Faculty Practice Plan has led to the generation of vast amounts of clinical data about this inner-city urban low-income African American population. To address the challenges, we propose the formation of the Howard University Clinical Research Network (HUCRN) as an addition to the consortium of the RCMI Clinical Research Network for Health Equity (RCMI-CRNHE). This effort will lead to an innovative, productive, and impactful research network for investigation of studies of high importance in minority health and health disparities. The significance of this project is derived from the necessity to study a health disparity affected population, burden of chronic disease, prevalent health disparities, engagement of an underrepresented clinical research workforce. Further we intend to introduce a new application of innovative data science called mHealth. We will develop a mHealth information technology infrastructure, clinical research informatics infrastructure including a clinical data repository, and we will conduct 2 pilot studies to assess the effectiveness of the infrastructure, policies, and processes that have been implemented.

研究摘要 非裔美国人在慢性病发病率和死亡率方面存在显著差异。值得注意的是， 消除健康差距需要显著改善慢性病管理， 这取决于提供和利用循证预防保健。提供高质量的 对非裔美国人的预防服务受到几个因素的阻碍，包括证据不足， 是临床研究试验中少数群体代表性不足的结果。事实上，美国 预防服务工作队（USPSTF）的建议声明经常引用代表性不足， 临床试验中的少数民族是研究的空白和局限。这影响了临床实践的发展 当某一特定疾病的流行病学不确定时， 不同的少数民族。不仅少数族裔作为研究参与者的代表性不足， 非裔美国人作为临床研究者的代表性同样严重不足，这部分是由于 非裔美国人在临床研究队伍中的代表性不足。解决这些差距 需要进行复杂的系统分析，开发创新方法，生成科学证据， 有效的知识传播。150多年来，霍华德大学为以下方面做出了重大贡献： 通过本科和研究生的医学教育来培养非裔美国医生。此外，本发明还提供了一种方法， 霍华德大学通过强有力的研究活动和全面的病人， 照顾哥伦比亚特区及以外地区的居民。电子病历的应用 系统由霍华德大学医院和霍华德大学教师实践计划导致了一代 大量的临床数据，这些数据是关于这个城市贫民区低收入的非裔美国人的。 为了应对这些挑战，我们建议成立霍华德大学临床研究中心 网络（HUCRN）作为RCMI健康公平临床研究网络联盟的补充 （RCMI-CRNHE）。这一努力将导致一个创新的，富有成效的和有影响力的研究网络， 对少数民族健康和健康差距方面的重要研究进行调查。其意义 该项目源于研究受健康差异影响的人口，慢性病负担， 普遍存在的健康差距，参与临床研究的劳动力人数不足。我们还打算 介绍一种创新数据科学的新应用，称为mHealth。我们将开发一个移动健康 信息技术基础设施，临床研究信息学基础设施，包括临床数据 我们会进行两项试验性研究，以评估基础设施、政策和 已经实施的过程。