Laboratory of Developmental Biology

发育生物学实验室

• 批准号: 10640551
• 负责人: Ian Amos Glass
• 金额: $ 75.29万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10640551
• 关键词: Atlases; Awareness; Barker Hypothesis; Biomedical Research; Brain; Cancer Biology; Cells; Clinic; Clinical; Collaborations; Collection; Communities; Congenital Abnormality; Custom; Development; Developmental Biology; Disease; Drug or chemical Tissue Distribution; Enrollment; Ensure; Epigenetic Process; Ethics; Expenditure; Experimental Designs; Fetal Development; Fetal Tissues; Fetus; Fostering; Funding; Future; Genetic; Genetic Diseases; Genomics; Goals; Guidelines; Healthcare; Human; Human Biology; Human Development; Immune System Diseases; Inflammatory; Institution; Laboratories; Laboratory Research; Logistics; Methods; Nature; Organ; Outcomes Research; Procedures; Process; Protocols documentation; Provider; Regenerative Medicine; Regulation; Research; Research Personnel; Resources; Sampling; Services; Shipping; Ships; Source; Specimen; Staging; Suspensions; Termination of pregnancy; Time; Tissue Banks; Tissue imaging; Tissues; United States National Institutes of Health; Universities; Work; base; biomedical scientist; cell repository; cellular imaging; design; epigenomics; fetal; human disease; human fetus tissue; improved; innovation; news; next generation sequencing; novel; novel strategies; preservation; pressure; programs; quality assurance; rare cancer; recruit; repository; sound; success

PROJECT SUMMARY/ABSTRACT In existence for more than 50 years, the Birth Defects Research Laboratory (BDRL) is now the only NIH- funded fetal tissue repository available to scientific recipients in the US. It is therefore a crucial scientific resource to retain for facilitating biomedical research, especially since alternative commercial laboratories are embroiled in controversy related to accusations of trade in fetal tissues. The scientific importance of fetal tissues to scientific research progress and health care is highlighted in a recent high profile Nature news-feature article (PMID 26659164). In fiscal year 2014, NIH funded 164 projects that utilized fetal tissues for a total expenditure of $76 million, with our laboratory as the only NIH fetal tissue repository, being the primary resource for many of these projects. The track record and success of the BDRL has therefore been proven many times over in its consistent provision of a host of scientific recipient-related services with fetal tissues, fully compliant with strict ethical and research guidelines, without misdemeanor. Spectacular technological advances in epigenetics, genomics, cellular and tissue imaging, and developmental biology have greatly expanded research opportunities for utilizing these precious tissues to facilitate current and future biomedical research progress. These advances establish the rationale for the laboratory to innovate and undertake multiple collaborations to both evaluate and demonstrate the utility of novel experimental approaches to maximize the scientific utility of these tissues. This application seeks to develop the resource beyond the core fundamental goal of the resource aka the systematic collection, staging, identification and processing of fetal specimens for distribution of tissues and derivatives to scientific recipients. We, therefore, propose to develop the research resource utility further by engaging with key collaborators to synergistically develop new services and thereby concurrently promote scientific awareness of these approaches to increase recipient recruitment and enhance research progress into the bases of human development and disease.

项目总结/摘要 出生缺陷研究实验室（BDRL）已经存在了50多年，现在是美国国立卫生研究院（NIH）唯一的一个 资助的胎儿组织库提供给美国的科学接受者。因此，这是一项重要的科学研究， 保留资源以促进生物医学研究，特别是因为替代商业实验室 卷入了与胎儿组织交易指控有关的争议。科学的重要性 胎儿组织的科学研究进展和医疗保健是在最近高调强调自然 新闻专题文章（PMID 26659164）。在2014财年，NIH资助了164个利用胎儿的项目， 我们的实验室是美国国立卫生研究院唯一的胎儿组织库， 成为许多项目的主要资源。BDRL的业绩记录和成功 因此，在其一贯提供的一系列与科学有关的知识方面， 服务与胎儿组织，完全符合严格的道德和研究准则，没有轻罪。 在表观遗传学、基因组学、细胞和组织成像方面取得了惊人的技术进步， 发育生物学极大地扩展了利用这些珍贵组织的研究机会， 促进当前和未来的生物医学研究进展。这些进步为 实验室进行创新，并进行多种合作，以评估和展示 新的实验方法，以最大限度地提高这些组织的科学效用。本申请旨在 开发资源，超越资源的核心基本目标，即系统收集， 对胎儿标本进行分期、鉴定和处理，以分发组织和衍生物， 科学的接受者。因此，我们建议进一步发展研究资源的效用， 与主要合作者协同开发新服务，从而同时促进科学 提高对这些方法的认识，以增加接受者的招募，并加强对 人类发展和疾病的基础。