Neurodevelopment in children from families with genetic frontotemporal dementia and Alzheimer's disease

遗传性额颞叶痴呆和阿尔茨海默病家庭儿童的神经发育

基本信息

项目摘要

Supplement Title: Neurodevelopment in children from families with genetic frontotemporal dementia and Alzheimer's disease Project summary/abstract: The current conceptualization of genetic frontotemporal dementia (FTD) and Alzheimer's disease (AD) is that they are neurodegenerative diseases with symptoms developing later in life. Yet, studies in animal models support the notion that autosomal dominant genes whose mutations cause these diseases play critical roles in neurodevelopment. Previous studies show that young adult presymptomatic carriers for FTD and AD mutations show detectable differences in the neural circuits that are also targeted during the symptomatic phase. It remains unknown how early these abnormalities start and the extent to which children with these mutations may show clinical overlap with neurodevelopmental disorders such as autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and language-based learning disabilities (LBLD). Studying children with FTD and AD mutations offers a unique model to evaluate lifelong neural circuit vulnerability since each disease targets distinct neural circuits. At the UCSF Dyslexia Center, we will cross-sectionally study children from families with a known genetic mutation for FTD or AD and compare them children with ASD, ADHD, and LBLD. Aims 1 and 2 will compare children carrying a genetic mutation for FTD and children carrying a genetic mutation for AD with noncarrier family members to identify differences in brain structure and neural network connectivity. Aim 3 will explore comparisons between mutation carriers and children with ASD, ADHD, and LBLD. Upon completion, we will have identified how early disease-specific neural circuit differences arise in genetic FTD and AD. These findings will reveal important insights into the underlying biology of these diseases and when biomarker differences develop during the lifespan for genetic FTD and AD.
补充标题:遗传性额颞叶痴呆家庭儿童的神经发育

项目成果

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SUZEE EURIE LEE的其他文献

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{{ truncateString('SUZEE EURIE LEE', 18)}}的其他基金

Neurodevelopment in children from families with genetic frontotemporal dementia and Alzheimer’s disease
遗传性额颞叶痴呆和阿尔茨海默病家族儿童的神经发育
  • 批准号:
    10364525
  • 财政年份:
    2022
  • 资助金额:
    $ 3.62万
  • 项目类别:
Neurodevelopment in children from families with genetic frontotemporal dementia and Alzheimer’s disease
遗传性额颞叶痴呆和阿尔茨海默病家族儿童的神经发育
  • 批准号:
    10571880
  • 财政年份:
    2022
  • 资助金额:
    $ 3.62万
  • 项目类别:
Neurodevelopment in children from families with genetic frontotemporal dementia and Alzheimer’s disease
遗传性额颞叶痴呆和阿尔茨海默病家族儿童的神经发育
  • 批准号:
    10810931
  • 财政年份:
    2022
  • 资助金额:
    $ 3.62万
  • 项目类别:
Defining trajectories of dynamic biomarkers for C9ORF72 repeat expansion carriers
定义 C9ORF72 重复扩增载体动态生物标志物的轨迹
  • 批准号:
    9922197
  • 财政年份:
    2018
  • 资助金额:
    $ 3.62万
  • 项目类别:
Defining trajectories of dynamic biomarkers for C9ORF72 repeat expansion carriers
定义 C9ORF72 重复扩增载体动态生物标志物的轨迹
  • 批准号:
    9763405
  • 财政年份:
    2018
  • 资助金额:
    $ 3.62万
  • 项目类别:
Defining trajectories of dynamic biomarkers for C9ORF72 repeat expansion carriers
定义 C9ORF72 重复扩增载体动态生物标志物的轨迹
  • 批准号:
    10390317
  • 财政年份:
    2018
  • 资助金额:
    $ 3.62万
  • 项目类别:
Detecting presymptomatic disease in inherited frontotemporal dementia
检测遗传性额颞叶痴呆的症状前疾病
  • 批准号:
    8713890
  • 财政年份:
    2011
  • 资助金额:
    $ 3.62万
  • 项目类别:
Detecting presymptomatic disease in inherited frontotemporal dementia
检测遗传性额颞叶痴呆的症状前疾病
  • 批准号:
    8516933
  • 财政年份:
    2011
  • 资助金额:
    $ 3.62万
  • 项目类别:
Detecting presymptomatic disease in inherited frontotemporal dementia
检测遗传性额颞叶痴呆的症状前疾病
  • 批准号:
    8241501
  • 财政年份:
    2011
  • 资助金额:
    $ 3.62万
  • 项目类别:
Detecting presymptomatic disease in inherited frontotemporal dementia
检测遗传性额颞叶痴呆的症状前疾病
  • 批准号:
    8334081
  • 财政年份:
    2011
  • 资助金额:
    $ 3.62万
  • 项目类别:

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