Improving HIV testing, linkage, and retention in care for men through U=U messaging
通过 U=U 信息传递改善男性的 HIV 检测、联系和护理保留
基本信息
- 批准号:10626959
- 负责人:
- 金额:$ 54.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:AIDS preventionAccelerationAchievementAcquired Immunodeficiency SyndromeAddressAdherenceAdoptionAfrica South of the SaharaAreaBehavioral SciencesCaringClinicCollaborationsCommunicable DiseasesCommunicationCommunitiesContinuity of Patient CareCounselingCountryCoupledDataEffectivenessEffectiveness of InterventionsEpidemicEpidemiologyEvaluationFrightGenderGoalsGovernmentGuidelinesHIVHIV InfectionsHIV SeropositivityHealthHealth BenefitHigh PrevalenceHuman immunodeficiency virus testIncidenceIncomeInstitutionInterventionKnowledgeLearningMethodsOutcomeParticipantPenetrationPersonsPrevalenceProcessProvinceRandomizedResearchResourcesSafe SexSexual PartnersShapesSiteSouth AfricaTestingUnsafe SexViralViral Load resultWomanWorkantiretroviral therapyanxiety reductionbehavioral economicscis-maleclinical practicecontextual factorseffectiveness evaluationeffectiveness-implementation RCTexperiencefuture implementationhuman centered designimplementation barriersimplementation effortsimplementation facilitationimprovedinnovationinsightmale healthmenmortality riskpeerprimary outcomeprototyperandomized trialsecondary outcomeservice deliveryservice uptakesexual HIV transmissionstandard of caresuccessful interventiontesting servicestesting uptaketheoriestherapy adherencetooltransmission processtreatment adherencetreatment as preventionuptakeyeast two hybrid system
项目摘要
PROJECT ABSTRACT
Increasing the coverage of HIV testing and treatment among people living with HIV (PLHIV) is essential for
ending the global AIDS epidemic. Unfortunately, compared to women, men living with HIV (MLHIV) are less
likely to know their HIV status, start anti-retroviral treatment, or achieve viral suppression. Given that new HIV
infections among women are driven, in part, by men’s testing and treatment gaps, reducing the gender gap in
testing uptake, treatment initiation and achievement of viral suppression by men must be prioritized in order to
accelerate the decline in HIV incidence among women, improve men’s HIV-related health outcomes and achieve
the UNAIDS 95-95-95 goals by 2030. In this study, we evaluate the effectiveness of Undetectable Equals
Untransmittable or “U=U” messaging for closing the gender gap in the HIV cascade. The U=U message
communicates the compelling idea that PLHIV who take ART and have an undetectable viral load (<200
copies/mL) cannot sexually transmit HIV. Particularly for men, the U=U message has the potential to accelerate
progress towards the 95-95-95 targets by: 1) reducing anxiety associated with HIV testing (1st 95); 2) encouraging
people who test HIV-positive to initiate ART (2nd 95); and 3) reducing fear of transmitting HIV to sexual partners
by promoting treatment adherence to achieve viral suppression (3rd 95). While there is a growing knowledge of
Treatment as Prevention (TasP)/U=U among PLWH in Western countries, the reach and penetration of the U=U
message in sub-Saharan Africa has been limited and few studies have tested the impacted of accessible U=U
messages on ART uptake and adherence in sub-Saharan Africa. Building on our prior work on U=U messaging
informed by behavioral economics and human-centered design, we propose to conduct two hybrid type 1
effectiveness-implementation randomized controlled trials to evaluate the impact of U=U messages on men’s
uptake of community-based HIV testing and treatment initiation (Aim 1), and achievement of viral suppression
(Aim 2). We will also conduct a multi-method evaluation to inform future implementation of U=U messaging
interventions. To improve the generalizability of our findings, we will conduct our study in two provinces in South
Africa (Western and Eastern Cape). If effective, our intervention can shape global HIV testing and treatment
counselling guidelines and practices. Our expert, multi-institutional collaborations will allow us to apply previous
research findings, leverage unique implementation platforms and resources, and rapidly disseminate our
findings.
项目摘要
增加艾滋病毒感染者(PLHIV)中艾滋病毒检测和治疗的覆盖率对于以下方面至关重要:
结束全球艾滋病的流行。不幸的是,与女性相比,男性艾滋病毒感染者(MLHIV)较少
他们可能知道自己的艾滋病毒状况,开始抗逆转录病毒治疗,或实现病毒抑制。鉴于新的艾滋病毒
女性感染的部分原因是男性的检测和治疗差距,
必须优先考虑男性接受检测、开始治疗和实现病毒抑制,
加快妇女艾滋病毒发病率的下降,改善男子与艾滋病毒有关的健康结果,
联合国艾滋病规划署到2030年的95-95-95目标。在这项研究中,我们评估的有效性不可检测的平等
无法传递或“U=U”的信息,以缩小艾滋病毒级联中的性别差距。U=U消息
传达了一个令人信服的想法,即接受抗逆转录病毒治疗且病毒载量检测不到(<200
拷贝/毫升)不能通过性传播艾滋病毒。特别是对男人来说,U=U的信息有可能加速
通过以下方式实现95-95-95目标:1)减少与艾滋病毒检测相关的焦虑(第一个95年); 2)鼓励
艾滋病毒检测呈阳性的人开始抗逆转录病毒治疗(第2个95);以及3)减少对将艾滋病毒传染给性伴侣的恐惧
通过促进治疗依从性来实现病毒抑制(3rd 95)。虽然越来越多的人知道
在西方国家的艾滋病毒/艾滋病感染者中,U= U的覆盖面和渗透率
撒哈拉以南非洲的信息有限,很少有研究测试可访问U=U的影响
关于撒哈拉以南非洲抗逆转录病毒疗法的接受和坚持的信息。基于我们之前在U=U消息传递方面的工作
根据行为经济学和以人为本的设计,我们建议进行两种混合型1
有效性-实施随机对照试验,以评估U=U消息对男性的影响
接受基于社区的艾滋病毒检测和开始治疗(目标1),并实现病毒抑制
(Aim 2)。我们还将进行多方法评估,为U=U消息传递的未来实施提供信息
干预措施。为了提高研究结果的普遍性,我们将在南方两个省进行研究,
非洲(西开普省和东开普省)。如果有效,我们的干预措施可以影响全球艾滋病毒检测和治疗
咨询指导方针和做法。我们的专家,多机构合作将使我们能够应用以前的
研究成果,利用独特的实施平台和资源,并迅速传播我们的
调查结果。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Improving HIV testing, linkage, and retention in care among South African men through U=U messaging: A study protocol for two sequential hybrid type 1 effectiveness- implementation randomized controlled trials.
通过 U=U 信息传递改善南非男性的 HIV 检测、联系和护理保留:两项连续混合 1 型有效性实施随机对照试验的研究方案。
- DOI:10.21203/rs.3.rs-3349696/v1
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Medina-Marino,Andrew;Sibanda,Nkosiyapha;Putt,Mary;JosephDavey,Dvora;Smith,Phillip;Thirumurthy,Harsha;Bekker,Linda-Gail;Buttenheim,Alison
- 通讯作者:Buttenheim,Alison
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Alison Meredith Buttenheim其他文献
Alison Meredith Buttenheim的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Alison Meredith Buttenheim', 18)}}的其他基金
Inoculating and boosting against HIV vaccine misinformation among adolescent girls and young women in South Africa
在南非少女和年轻女性中接种和预防艾滋病毒疫苗错误信息
- 批准号:
10620056 - 财政年份:2023
- 资助金额:
$ 54.37万 - 项目类别:
Improving HIV testing, linkage, and retention in care for men through U=U messaging
通过 U=U 信息传递改善男性的 HIV 检测、联系和护理保留
- 批准号:
10483486 - 财政年份:2022
- 资助金额:
$ 54.37万 - 项目类别:
Improving participation in vector control campaigns
提高病媒控制活动的参与度
- 批准号:
8759325 - 财政年份:2014
- 资助金额:
$ 54.37万 - 项目类别:
Improving participation in vector control campaigns
提高病媒控制活动的参与度
- 批准号:
8917290 - 财政年份:2014
- 资助金额:
$ 54.37万 - 项目类别:
Vaccination status of children exempted from school-entry immunization mandates
免于入学免疫接种规定的儿童的疫苗接种状况
- 批准号:
8750180 - 财政年份:2014
- 资助金额:
$ 54.37万 - 项目类别:
Improving participation in vector control campaigns
提高病媒控制活动的参与度
- 批准号:
9091592 - 财政年份:2014
- 资助金额:
$ 54.37万 - 项目类别:
Improving participation in vector control campaigns
提高病媒控制活动的参与度
- 批准号:
9318573 - 财政年份:2014
- 资助金额:
$ 54.37万 - 项目类别:
相似海外基金
EXCESS: The role of excess topography and peak ground acceleration on earthquake-preconditioning of landslides
过量:过量地形和峰值地面加速度对滑坡地震预处理的作用
- 批准号:
NE/Y000080/1 - 财政年份:2024
- 资助金额:
$ 54.37万 - 项目类别:
Research Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328975 - 财政年份:2024
- 资助金额:
$ 54.37万 - 项目类别:
Continuing Grant
SHINE: Origin and Evolution of Compressible Fluctuations in the Solar Wind and Their Role in Solar Wind Heating and Acceleration
SHINE:太阳风可压缩脉动的起源和演化及其在太阳风加热和加速中的作用
- 批准号:
2400967 - 财政年份:2024
- 资助金额:
$ 54.37万 - 项目类别:
Standard Grant
Market Entry Acceleration of the Murb Wind Turbine into Remote Telecoms Power
默布风力涡轮机加速进入远程电信电力市场
- 批准号:
10112700 - 财政年份:2024
- 资助金额:
$ 54.37万 - 项目类别:
Collaborative R&D
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328973 - 财政年份:2024
- 资助金额:
$ 54.37万 - 项目类别:
Continuing Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328972 - 财政年份:2024
- 资助金额:
$ 54.37万 - 项目类别:
Continuing Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332916 - 财政年份:2024
- 资助金额:
$ 54.37万 - 项目类别:
Standard Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332917 - 财政年份:2024
- 资助金额:
$ 54.37万 - 项目类别:
Standard Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328974 - 财政年份:2024
- 资助金额:
$ 54.37万 - 项目类别:
Continuing Grant
Study of the Particle Acceleration and Transport in PWN through X-ray Spectro-polarimetry and GeV Gamma-ray Observtions
通过 X 射线光谱偏振法和 GeV 伽马射线观测研究 PWN 中的粒子加速和输运
- 批准号:
23H01186 - 财政年份:2023
- 资助金额:
$ 54.37万 - 项目类别:
Grant-in-Aid for Scientific Research (B)