Research Program

研究计划

• 批准号: 10460466
• 负责人: Alison Meredith Buttenheim
• 金额: $ 65.46万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10460466
• 关键词: Address; Adherence; American; Area; Artificial Intelligence; Behavior; Cancer Center; Cancer Control; Cancer Control Research Program; Caring; Collaborations; Continuity of Patient Care; Data; Data Pooling; Development; Doctor of Philosophy; Ensure; Evidence based practice; Eye; Funding; Grant; Health; Healthcare; Incubators; Individual; Investments; Laboratories; Lead; Leadership; Learning; Life; Link; Literature; Machine Learning; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Measurement; Measures; Methodology; Methods; Mission; Nature; Oral; Outcome; Patients; Pennsylvania; Pilot Projects; Prevention; Process; Psychiatry; Public Health; Quality of Care; Research; Research Activity; Research Personnel; Resources; Scientific Advances and Accomplishments; Talents; Testing; Tobacco Use Cessation; Tobacco use; Universities; Variant; advanced breast cancer; behavioral economics; bone; cancer care; cancer therapy; care delivery; chemotherapy; comparative; compliance behavior; design; evidence base; heuristics; high reward; implementation science; implementation strategy; implementation study; improved; improved outcome; infancy; innovation; insight; lens; multidisciplinary; programs; reduce tobacco use; response; screening; survivorship; symptom management; uptake

The grand challenge addressed by the Penn Implementation Science Center in Cancer Control (ISC3) is to apply insights from behavioral economics to rapidly accelerate the pace at which we deploy evidence-based practices for patients with cancer, thereby improving cancer care quality and outcomes. Our Research Program, led by Drs. Beidas (implementation science expert) and Buttenheim (behavioral economics expert), will oversee the development and testing of implementation strategies within the Implementation Laboratory. Our implementation strategy design and testing approach includes the patient and clinician as targets, and is informed by behavioral economics to ‘nudge’ individuals to make optimal decisions for implementing evidence-based care. The Penn ISC3 is built on three principles. First, implementation science has not leveraged the rich literature from behav- ioral economics, which has elucidated many of the heuristics that underlie decisions and behaviors contributing to suboptimal health outcomes. Approaches from behavioral economics have not been applied systematically alongside implementation science to improve cancer care; these approaches aim to accelerate uptake of evi- dence-based practices. Second, implementation science has not applied methods to fail fast and learn quickly, which we will incorporate through the application of rapid cycle approaches. Third, research to identify mecha- nisms of the implementation strategies to improve uptake of evidence-based practices is in its infancy. The Research Program includes investigators with expertise in implementation science, behavioral economics, can- cer care delivery research, healthcare innovation, measurement, and mixed methods. In the first two years, we propose three Signature Pilot Projects (SPPs) and two Methods Projects that both support the SPPs and ad- vance the science of implementation with an eye towards rapid learning. SPP 1 (Jenssen/Leone) tests patient- and clinician-directed implementation strategies to increase referral to tobacco cessation programs in patients receiving cancer treatment. SPP 2 (Bekelman/Patel) tests patient- and clinician-directed implementation strate- gies to increase use of higher-value bone modifying agents in patients with advanced breast, lung, and prostate cancer. Common methods and measures link these projects to provide pooled data to accomplish our objectives of testing multilevel implementation strategies to elucidate mechanisms and targets. SPP 3 (Bekelman/Rendle), the most exploratory and high-reward SPP, will test a patient-directed implementation strategy that leverages artificial intelligence and machine learning to promote oral chemotherapy adherence and symptom management. Methods Project 1 will develop a toolkit for the application of rapid cycle approaches (Asch/Buttenheim); Methods Project 2 will use qualitative comparative analysis to characterize multilevel contextual variation and mechanisms (Barg/Rendle). The scientific advances to come out of the Research Program will have a significant public health impact, consistent with NCI priorities, by rapidly improving uptake of evidence-based practices to improve cancer care quality and outcomes for millions of Americans with cancer. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

宾夕法尼亚大学癌症控制实施科学中心 (ISC3) 面临的重大挑战是应用 行为经济学的见解可快速加快我们部署循证实践的步伐 为癌症患者提供帮助，从而提高癌症护理质量和结果。我们的研究计划，由 博士。 Beidas（实施科学专家）和 Buttenheim（行为经济学专家）将监督 在实施实验室内制定和测试实施策略。我们的实施 策略设计和测试方法以患者和临床医生为目标，并通过行为来了解 经济学“推动”个人做出实施循证护理的最佳决策。宾夕法尼亚大学 ISC3 建立在三个原则之上。首先，实施科学没有利用来自行为的丰富文献。 口头经济学，它阐明了许多决策和行为背后的启发法 导致健康结果不佳。行为经济学的方法尚未得到系统应用 与实施科学一起改善癌症护理；这些方法旨在加速对evi-的吸收 基于密度的实践。其次，实施科学并没有应用快速失败和快速学习的方法， 我们将通过应用快速循环方法将其纳入其中。第三，研究识别机械 旨在提高循证做法采用率的实施战略的国家主义尚处于起步阶段。这 研究计划包括具有实施科学、行为经济学、can- cer 护理服务研究、医疗保健创新、测量和混合方法。最初的两年里，我们 提出三个签名试点项目（SPP）和两个方法项目，既支持 SPP，又支持 着眼于快速学习，推进实施科学。 SPP 1（Jenssen/Leone）测试患者- 以及临床医生指导的实施策略，以增加患者转诊至戒烟计划 接受癌症治疗。 SPP 2（Bekelman/Patel）测试患者和临床医生指导的实施策略 希望在晚期乳腺癌、肺癌和前列腺患者中增加使用更高价值的骨改性剂 癌症。通用方法和措施将这些项目联系起来，提供汇总数据来实现我们的目标 测试多层次实施策略以阐明机制和目标。 SPP 3（贝克尔曼/伦德尔）， 最具探索性和高回报的 SPP，将测试以患者为导向的实施策略，该策略利用 人工智能和机器学习促进口服化疗的依从性和症状管理。 方法项目 1 将开发一个用于快速循环方法应用的工具包（Asch/Buttenheim）；方法 项目 2 将使用定性比较分析来表征多层次的背景变化和机制 （巴格/伦德尔）。该研究计划取得的科学进步将对公共健康产生重大影响 通过快速提高循证实践的采用来改善癌症，从而与 NCI 的优先事项保持一致，产生影响 数百万美国人癌症患者的护理质量和结果。 PHS 398/2590（修订版 06/09） 页面延续 格式页面