Novel Therapeutics for Colon Cancer treatment

结肠癌治疗新疗法

• 批准号: nhmrc : GNT1064987
• 负责人: A/Pr Frederic Hollande
• 金额: $ 62.56万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-therapeutics-colon-cancer-treatment/1344878
• 关键词: Novel; Therapeutics; Colon; Cancer; treatment

Colorectal cancer (CRC) is the 3rd most common cancer worldwide. 85% of CRC arises from mutations in the Wnt signalling pathway. We have shown that AZD1480, a drug that blocks Janus kinases (Jak) can prevent the appearance of Wnt mutant tumours and stop the growth of already established CRC in animal models. This project will test whether Jak inhibitors can improve treatment outcome and prolong disease free survival.

结直肠癌（CRC）是全球第三大常见癌症。85%的CRC是由Wnt信号通路的突变引起的。我们已经证明，AZD 1480，一种阻断Janus激酶（Jak）的药物，可以防止Wnt突变肿瘤的出现，并阻止动物模型中已经建立的CRC的生长。该项目将测试Jak抑制剂是否可以改善治疗结果并延长无病生存期。