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Targeting Colon Cancer with Jak inhibitors

Targeting Colon Cancer with Jak inhibitors
使用 Jak 抑制剂靶向结肠癌
批准号:
nhmrc : 1064987
负责人:
A/Pr Frederic Hollande
金额:
$43.13万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31

项目摘要

项目成果

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中文摘要
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英文摘要
Colorectal cancer (CRC) is the 3rd most common cancer worldwide. 85% of CRC arises from mutations in the Wnt signalling pathway. We have shown that AZD1480, a drug that blocks Janus kinases (Jak) can prevent the appearance of Wnt mutant tumours and stop the growth of already established CRC in animal models. This project will test whether Jak inhibitors can improve treatment outcome and prolong disease free survival.
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Volatile Anaesthesia and Cancer Recurrence
  • 批准号:
    nhmrc : 1147498
  • 项目类别:
    Project Grants
  • 资助金额:
    $43.78万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Frederic Hollande
  • 依托单位:
Novel Therapeutics for Colon Cancer treatment
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    nhmrc : GNT1064987
  • 项目类别:
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  • 资助金额:
    $62.56万
  • 财政年份:
    2014
  • 负责人:
    A/Pr Frederic Hollande
  • 依托单位:
Genetic validation of Stat3 as a tractable pharmacological target in gastrointestinal disease
  • 批准号:
    nhmrc : 1069024
  • 项目类别:
    Project Grants
  • 资助金额:
    $39.14万
  • 财政年份:
    2014
  • 负责人:
    A/Pr Frederic Hollande
  • 依托单位:
Elucidating the role of claudin-2 in tumour initiation and metastasis development from colorectal cancer: consequence for tumour relapse
  • 批准号:
    nhmrc : 1049561
  • 项目类别:
    Project Grants
  • 资助金额:
    $26.6万
  • 财政年份:
    2013
  • 负责人:
    A/Pr Frederic Hollande
  • 依托单位:
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