Elucidating the role of claudin-2 in tumour initiation and metastasis development from colorectal cancer: consequence for tumour relapse

阐明claudin-2在结直肠癌肿瘤发生和转移发展中的作用：肿瘤复发的后果

• 批准号: nhmrc : 1049561
• 负责人: A/Pr Frederic Hollande
• 金额: $ 26.6万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-role-claudin-tumour-relapse/112093
• 关键词: Elucidating; role; claudin; tumour; initiation

Mortality from colorectal cancer is often due to the development of metastases. Cancer stem cells (CSC) are suspected to provide a major drive for metastasis development, to resist current therapies, and to initiate tumour relapse. Yet, little is known about mechanisms that control CSC behaviour. Our project investigates the role of claudin-2, a cell adhesion protein that is strongly overexpressed in colorectal cancer, in the regulation of CSCs, metastasis development and tumour relapse.

结直肠癌的死亡率通常是由于转移的发展。癌症干细胞（CSC）被怀疑是转移发展的主要驱动力，以抵抗目前的治疗，并启动肿瘤复发。然而，对控制CSC行为的机制知之甚少。我们的项目研究了claudin-2的作用，claudin-2是一种在结直肠癌中强烈过表达的细胞粘附蛋白，在CSC，转移发展和肿瘤复发的调节中。