阐明claudin-2在结直肠癌肿瘤发生和转移发展中的作用：肿瘤复发的后果-猫眼课题宝

阐明claudin-2在结直肠癌肿瘤发生和转移发展中的作用：肿瘤复发的后果

批准号：

nhmrc : 1049561

负责人：

A/Pr Frederic Hollande

金额：

$26.6万

依托单位：

The University of Melbourne

依托单位国家：

澳大利亚

项目类别：

Project Grants

财政年份：

2013

资助国家：

澳大利亚

项目状态：

已结题

起止时间：

2013-01-01 至 2016-12-31

来源：

https://researchdata.edu.au/elucidating-role-claudin-tumour-relapse/112093

关键词：

Elucidating role claudin tumour initiation

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英文摘要

Mortality from colorectal cancer is often due to the development of metastases. Cancer stem cells (CSC) are suspected to provide a major drive for metastasis development, to resist current therapies, and to initiate tumour relapse. Yet, little is known about mechanisms that control CSC behaviour. Our project investigates the role of claudin-2, a cell adhesion protein that is strongly overexpressed in colorectal cancer, in the regulation of CSCs, metastasis development and tumour relapse.

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