Etiology and Treatment of Alcohol Dependence

康涅狄格大学酒精研究中心(UConn RC)的这份P50申请表要求提交五份 为该中心关于酒精依赖易感性和前景光明的研究项目提供了多年的资金 生物和心理社会治疗干预。管理核心描述了康涅狄格州大学ARC的 与研究和出版有关的组织框架、质量控制机制和支持 研究设施。访问学者计划，咨询和指导活动，以及期刊编辑 活动加强了康涅狄格州大学ARC作为区域和国家资源的作用。研究项目#1将专注于 关于几种可能的饮酒应对(DTC)，与压力相关的途径(包括遗传)可能会增加 前大学生对酗酒及酒精相关问题的易感性 再加上毕业后的几年。这项研究将检查三个评估波在日水平上的变化 DTC动机与其前因和结果之间的关联以及这些每日变化 过程与个性因素和其他变量之间的个体差异有关。继续我们的 中心对新疗法的重视，我们提出了另外两项研究。双重强化偶然性 酒精使用障碍的管理(CM)，研究项目2，将评估强化的效果 磷脂酰乙醇(PEH)阴性结果与CM对患者的几种结局的关注 在社区治疗中心。据推测，这种结合将导致更多的出勤率，更多的 佩奇阴性样本，自我报告的不饮酒天数比例较高，而重度 喝酒的日子。研究3是评估度他雄胺安全性和有效性的安慰剂对照试验 在患有AUD的男性和女性中。减少饮酒和治疗效果的持久性将是 检查过了。如果复制，FKBP5的一个变体对度他雄胺治疗效果的缓和作用将扩大 不断增加的潜在基因预测因子，促进了个性化药物的开发 AUD的治疗建议。最后，拟议的试点研究核心将支持多达六项研究，这些研究 与该中心的脆弱性和酒精依赖的新治疗方法和帮助的主题直接相关 支持新接触酒精研究的初级调查人员和教员。

This P50 application from the University of Connecticut Alcohol Research Center (UCONN RC) requests five years of funding for the Center's research programs on vulnerability to alcohol dependence and promising biological and psychosocial treatment interventions. The Administrative Core describes the UConn ARC's organizational framework, quality control mechanisms related to research and publications, and supporting research facilities. The visiting scholars program, consulting and mentoring activities, and journal editorship activities strengthen the UConn ARC's role as a regional and national resource. Research Project #1 will focus on several possible drinking to cope (DTC), stress-related pathways (including genetic) that may increase the susceptibility for developing heavy drinking and alcohol-related problems among former college students six plus years after graduation. This study will examine changes across 3 assessment waves in day-level associations among DTC motivation and its antecedents and outcomes and whether changes in these daily processes are related to individual differences across personality factors and other variables. Continuing our Center's emphasis on novel treatments, we propose two additional studies. Dual reinforcement contingency management (CM) for alcohol use disorders, Research Project #2, will evaluate the effects of reinforcing negative phosphatidylethanol (PEth) results alongside CM for attendance on several outcomes among patients in community treatment centers. It is hypothesized that this combination will result in greater attendance, more PEth negative samples, higher proportions of self-reported non-drinking days, and lower proportions of heavy drinking days. Research study #3 is a placebo controlled trial to evaluate the safety and efficacy of dutasteride among male and females with AUD. Reductions in drinking and the persistence of treatment effects will be examined. If replicated, the moderation of dutasteride treatment effects by a variant in FKBP5 would expand the growing list of potential genetic predictors, facilitating the development of personalized medication treatment recommendations for AUD. Finally, the proposed pilot studies core will support up to six studies that relate directly to the Center's themes of vulnerability and novel treatments for alcohol dependence and help support junior investigators and faculty new to alcohol research.