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Etiology and Treatment of Alcohol Dependence

酒精依赖的病因和治疗

基本信息

批准号：
10626832
负责人：
Cathryn Glanton Holzhauer
金额：
$ 133.16万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-06 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10626832
关键词：
Alcohol abuse Alcohol consumption Alcohol dependence Alcohols Basic Science Behavior Therapy Biological Biological Factors Biological Markers Biosensor Buspirone Central Nervous System Childhood Chronic Client Clinical Clinical Investigator Communities Connecticut Consultations Consummatory Behavior Data Dependence Development Dutasteride Education Etiology Faculty Family Female Fluoxetine Funding Genetic Heavy Drinking Individual Individual Differences Institution Interdisciplinary Study Intervention Journals Laboratories Mentors Motivation Naltrexone National Institute on Alcohol Abuse and Alcoholism Nature Outcome Outcomes Research Pathologic Pathway interactions Patient Self-Report Patients Personality Personality Traits Pharmaceutical Preparations Pharmacological Treatment Philosophy Pilot Projects Population Postdoctoral Fellow Predisposition Prevention strategy Problem behavior Process Productivity Psychological Factors Psychological reinforcement Publications Quality Control Recommendation Recording of previous events Research Research Methodology Research Personnel Research Project Grants Research Support Resources Role Safety Sampling Scholars Program Scientist Specific qualifier value Stress Students Treatment outcome Universities Variant Vulnerable Populations Work acamprosate alcohol abuse therapy alcohol related problem alcohol research alcohol use disorder clinical investigation clinical practice contingency management coping drinking drinking behavior experience genetic predictors high risk population improved informal learning interest male novel patient retention pharmacologic phosphatidylethanol placebo controlled trial preclinical study problem drinker programs psychosocial research facility research study social factors sound theories therapy design topiramate treatment center treatment effect treatment research undergraduate student university student visiting scholar

项目摘要

This P50 application from the University of Connecticut Alcohol Research Center (UCONN RC) requests five years of funding for the Center's research programs on vulnerability to alcohol dependence and promising biological and psychosocial treatment interventions. The Administrative Core describes the UConn ARC's organizational framework, quality control mechanisms related to research and publications, and supporting research facilities. The visiting scholars program, consulting and mentoring activities, and journal editorship activities strengthen the UConn ARC's role as a regional and national resource. Research Project #1 will focus on several possible drinking to cope (DTC), stress-related pathways (including genetic) that may increase the susceptibility for developing heavy drinking and alcohol-related problems among former college students six plus years after graduation. This study will examine changes across 3 assessment waves in day-level associations among DTC motivation and its antecedents and outcomes and whether changes in these daily processes are related to individual differences across personality factors and other variables. Continuing our Center's emphasis on novel treatments, we propose two additional studies. Dual reinforcement contingency management (CM) for alcohol use disorders, Research Project #2, will evaluate the effects of reinforcing negative phosphatidylethanol (PEth) results alongside CM for attendance on several outcomes among patients in community treatment centers. It is hypothesized that this combination will result in greater attendance, more PEth negative samples, higher proportions of self-reported non-drinking days, and lower proportions of heavy drinking days. Research study #3 is a placebo controlled trial to evaluate the safety and efficacy of dutasteride among male and females with AUD. Reductions in drinking and the persistence of treatment effects will be examined. If replicated, the moderation of dutasteride treatment effects by a variant in FKBP5 would expand the growing list of potential genetic predictors, facilitating the development of personalized medication treatment recommendations for AUD. Finally, the proposed pilot studies core will support up to six studies that relate directly to the Center's themes of vulnerability and novel treatments for alcohol dependence and help support junior investigators and faculty new to alcohol research.

康涅狄格大学酒精研究中心（UCONN RC）的这份P50申请要求五个多年来，该中心的研究项目对酒精依赖的脆弱性和有前途的资金生物和心理社会治疗干预。行政核心描述了康州大学ARC的组织框架、与研究和出版物有关的质量控制机制，研究设施。访问学者计划，咨询和指导活动，以及期刊编辑活动加强了康州大学ARC作为区域和国家资源的作用。研究项目#1将重点几种可能的饮酒科普（DTC），压力相关的途径（包括遗传），可能会增加前大学生酗酒及酒精相关问题的易感性再加上毕业后的几年。本研究将检查日水平3个评估波的变化 DTC动机与其前因和结果之间的关联，以及这些日常变化是否过程与人格因素和其他变量的个体差异有关。继续我们中心的重点是新的治疗方法，我们提出了两个额外的研究。双重强化权变酒精使用障碍管理（CM）研究项目#2将评估强化的效果在患者中，磷脂酰乙醇（PEth）结果与CM一起用于治疗几种结局在社区治疗中心。据推测，这种组合将导致更大的出勤率，更多 PEth阴性样本，自我报告的非饮酒天数比例较高，重度饮酒比例较低。喝酒的日子研究#3是一项安慰剂对照试验，旨在评价度他雄胺的安全性和有效性男性和女性中，减少饮酒和治疗效果的持续性将是考察如果复制，FKBP 5变异体对度他雄胺治疗效果的调节作用将扩大越来越多的潜在遗传预测因子，促进了个性化药物的开发治疗建议AUD。最后，拟议的试点研究核心将支持多达六项研究，直接关系到该中心的脆弱性和酒精依赖的新疗法和帮助的主题支持初级研究人员和酒精研究新手。

项目成果

期刊论文数量（34）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The impact of adverse childhood experiences on adolescent health risk indicators in a community sample.

DOI：
10.1037/tra0001004
发表时间：
2021-03
期刊：
Psychological trauma : theory, research, practice and policy
影响因子：
0
作者：
Meeker EC;O'Connor BC;Kelly LM;Hodgeman DD;Scheel-Jones AH;Berbary C
通讯作者：
Berbary C

Meet the parents: Parental interactions, social influences, and college drinking.

DOI：
10.1016/j.addbeh.2020.106624
发表时间：
2021-01
期刊：
Addictive behaviors
影响因子：
4.4
作者：
Hamilton HR;Armeli S;Tennen H
通讯作者：
Tennen H

The new normal: Changes in drinking norms from college to postcollege life.

新常态：从大学到大学后生活饮酒规范的变化。

DOI：
10.1037/adb0000562
发表时间：
2020
期刊：
Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
影响因子：
0
作者：
Hamilton,HannahR;Armeli,Stephen;Litt,Mark;Tennen,Howard
通讯作者：
Tennen,Howard

Temporal instability in brain activation: a novel paradigm for evaluating the maintenance of attention among substance dependent patients.