Biostatistics and Research Design Shared Resource

生物统计学和研究设计共享资源

• 批准号: 10627042
• 负责人: Sara Katherine Vesely
• 金额: $ 13.94万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627042
• 关键词: Accounting; Area; Basic Science; Bioinformatics; Biometry; Biostatistical Methods; Cancer Center; Cancer Center Support Grant; Centers of Research Excellence; Charge; Cherokee Indian; Clinical Cancer Center; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Complex; Conceptions; Consultations; Data; Data Analyses; Data Collection; Databases; Development; Doctor of Philosophy; Educational process of instructing; Enrollment; Ensure; Epidemiology; Faculty; Funding; Future; Genetic; Goals; Grant; Growth; Knowledge; Machine Learning; Malignant Neoplasms; Manuscripts; Mentors; Meta-Analysis; Methods; Monitor; Observational Study; Oklahoma; Outcome; Peer Review; Phase; Phase I Clinical Trials; Pilot Projects; Play; Postdoctoral Fellow; Preparation; Productivity; Protocols documentation; Random Allocation; Reporting; Reproducibility; Research; Research Activity; Research Design; Research Personnel; Resource Sharing; Resources; Retrospective Studies; Review Committee; Role; Safety; Sample Size; Sampling; Scheme; Services; Site; Statistical Data Interpretation; Statistical Methods; Students; Surveys; Training and Education; Translating; Translational Research; United States National Institutes of Health; Work; Writing; anticancer research; community based participatory research; cost efficient; data integration; design; doctoral student; education research; experimental study; genetic analysis; innovation; investigator-initiated trial; member; multiple data sources; novel; phase I trial; phase II trial; pilot trial; primary endpoint; programs; randomized, clinical trials; recruit; research to practice; student training; systematic review; translational cancer research; undergraduate student; web page

BIOSTATISTICS AND RESEARCH DESIGN SHARED RESOURCE: ABSTRACT The Biostatistics and Research Design Shared Resource (BRD SR) plays a critical role in research activities at the Stephenson Cancer Center (SCC) through supporting biostatistical and research design needs for SCC members. The BRD SR is directed by Sara Vesely, PhD (CPC) and co-directed by Daniel Zhao, PhD (CT), and has seven PhD-level faculty and six staff. The BRD SR provides biostatistical and research design assistance for a variety of projects, including basic science experiments, meta-analyses, secondary data analysis, genetic data and bioinformatics analysis, observational studies, qualitative studies, community research, pilot trials, randomized clinical trials, and phase I investigator-initiated trials (IITs). Major consultative services provided by BRD SR faculty include assistance with refining aims and outcomes, appropriate study design selection, data collection planning, development of statistical analysis and data monitoring plans, creation of random allocation schemes, sample size calculations, and grant preparation. The BRD SR is a cost-efficient resource to assist SCC members in a timely manner, free of direct charge, through project conception, development, grant writing, implementation, analysis, and manuscript writing. Services can be accessed online via the SCC / BRD SR webpages, with an online service request form. BRD SR faculty and staff have a diverse set of expertise, including database creation and management, research design, biostatistical analysis, statistical genetics analysis, geo-spatial methods, sampling strategies and weighting, data monitoring, and grant writing. In 2021, 57 total SCC members utilized the BRD SR, accounting for 73% of BRD SR usage. SCC members with peer-reviewed support (n=41) accounted for 53% of the total usage. In 2021, the BRD SR supported over 140 cancer-focused SCC projects (ongoing grants, IITs, and other projects) and 105 grant submissions (submissions and resubmissions). From 2017 to 2021, the BRD SR provided biostatistical consultation services to 80 full and associate members across all three SCC programs. The number of SCC member users has steadily increased each year – 36 (2017), 44 (2018), 46 (2019), 50 (2020), 57 (2021) – a 58% increase in annual SR usage from the beginning to the end of the reporting period. Future plans are focused on the addition of faculty (2-4) and staff (2-4) biostatisticians over the next five years, expertise to be determined by SCC strategic growth and needs, and to be recruited in partnership with the Department of Biostatistics and Epidemiology.

生物统计学和研究设计共享资源：摘要 生物统计和研究设计共享资源(BRD SR)在以下研究活动中发挥着关键作用 斯蒂芬森癌症中心(SCC)通过支持SCC的生物统计和研究设计需求 会员。BRD SR由Sara Vesely博士(CPC)执导，Daniel赵博士(CT)联合执导， 拥有7名博士生教职员工和6名教职工。BRD SR提供生物统计和研究设计 协助各种项目，包括基础科学实验、荟萃分析、二次数据 分析、遗传数据和生物信息学分析、观察性研究、定性研究、社区 研究、先导试验、随机临床试验和第一阶段研究人员发起试验(IITs)。主要咨询服务 BRD SR教职员工提供的服务包括协助完善目标和结果、适当的研究 设计选择、数据收集规划、制定统计分析和数据监测计划； 创建随机分配方案、计算样本量和准备赠款。 BRD SR是一种经济高效的资源，可以免费、及时地向SCC成员提供帮助， 通过项目构思、开发、拨款撰写、实施、分析和撰写稿件。 服务可以通过SCC/BRD SR网页在线访问，并带有在线服务请求表。BRD 高级教职员工拥有不同的专业知识，包括数据库创建和管理、研究 设计、生物统计分析、统计遗传学分析、地理空间方法、抽样策略和 称重、数据监控和拨款申请。2021年，共有57个SCC成员使用了BRD SR， 73%的BRD SR使用率。获得同行评审支持的SCC成员(n=41)占总数的53% 用法。2021年，BRD SR支持了140多个以癌症为重点的SCC项目(持续赠款、IIT和其他 项目)和105份赠款申请(提交和重新提交)。从2017年到2021年，BRD SR 为所有三个SCC项目的80名正式成员和准成员提供生物统计咨询服务。 SCC会员用户数量每年稳步增长--36(2017)、44(2018)、46(2019)、50 (2020)、57(2021)--从报告期开始到结束，年度服务请求使用量增加了58%。 未来计划的重点是在未来五年增加教职员工(2-4名)和工作人员(2-4名)生物统计员， 专业知识将由SCC战略增长和需求确定，并将与 生物统计和流行病学系。