Biostatistics and Research Design Shared Resource

生物统计与研究设计共享资源-摘要 斯蒂芬森癌症中心(SCC)的生物统计和研究设计共享资源(BRD SR) 是SCC管理的机构，在Sara Vesely博士的指导下，为SCC成员提供 为各种项目提供统计援助，包括基础科学实验、荟萃分析、次级 数据分析、观察性研究、定性研究、社区研究、试点试验、随机临床 试验和早期阶段由研究者发起的试验(IITs)。BRD SR教职员工提供的主要咨询服务 包括协助改进目标和结果、适当研究设计选择、数据收集 规划、制定统计分析和数据监测计划、创建随机分配 计划、样本量计算和赠款准备。BRD SR教职员工还提供数据分析支持 所有与癌症相关的研究，包括拨款申请的初步数据、试点数据 分析摘要和稿件准备。BRD SR教职员工服务于各种SCC委员会(例如， PRMC、DSMC)协助所有方面的方案审查和监测，以确保严密性和可重复性。 2016年，BRD SR有6名教职生物统计员(总资助2.05 FTE)和3名GRA支持人员。BRD 高级教职员工每月召开两次常设会议，由韦斯利博士主持，讨论行政管理问题。 政策和操作问题。为了方便出入，BRD SR在Peggy和 查尔斯·斯蒂芬森癌症中心大楼(五楼)，这是SCC的主要临床和行政部门 大楼和大学研究园区(四楼)，这是SCC的癌症预防和 控制程序。BRD SR生物统计学学院的学术办公室设在 俄亥俄州立大学公共卫生学院大楼内的生物统计学和流行病学。 BRD SR对于实现SCC的科学目标至关重要，BRD SR教职员工已经做出了 对许多特定于计划的研究项目的重要贡献(在研究战略中描述 节)。2016年，BRD SR用户总数(52人)中有24人(46%)是经过同行审查的SCC成员 支持。BRD SR还为8名SCC成员提供服务，没有经过同行审查的支持。SCC成员 占该设施总用户的62%，突出了该设施的高利用率和影响 关于推进SCC的研究。2016年，BRD SR共支持了93个项目，其中63个是新项目，30个是新项目 正在进行中。自2012年以来，BRD SR已为超过一半的 SCC目前有96个正式会员和准会员。

BIOSTATISTICS AND RESEARCH DESIGN SHARED RESOURCE – ABSTRACT The Biostatistics and Research Design Shared Resource (BRD SR) at the Stephenson Cancer Center (SCC) is an SCC-managed facility, under the direction of Sara Vesely, PhD, which provides SCC members with statistical assistance for a variety of projects, including basic science experiments, meta-analyses, secondary data analysis, observational studies, qualitative studies, community research, pilot trials, randomized clinical trials and early-phase investigator-initiated trials (IITs). Major consultative services provided by BRD SR faculty include assistance with refining aims and outcomes, appropriate study design selection, data collection planning, development of statistical analysis and data monitoring plans, creation of random allocation schemes, sample size calculations and grant preparation. BRD SR faculty also provide data analysis support across the full spectrum of cancer-related research, including preliminary data for grant submissions, pilot data analysis and abstract and manuscript preparation. BRD SR faculty serve on a variety of SCC committees (e.g., PRMC, DSMC) to assist with all aspects of protocol review and monitoring to ensure rigor and reproducibility. In 2016, the BRD SR had six faculty biostatisticians (2.05 total funded FTE) and three GRA support staff. BRD SR faculty and staff meet twice monthly in a standing meeting, chaired by Dr. Vesely, to discuss administrative policies and operational issues. To facilitate access, the BRD SR has dedicated office space in the Peggy and Charles Stephenson Cancer Center building (fifth floor), which is the SCC's main clinical and administrative building, and in University Research Park (fourth floor), which houses the SCC's Cancer Prevention and Control program. The academic offices for the BRD SR biostatistics faculty are located in the Department of Biostatistics and Epidemiology (BSE) in the OU College of Public Health building. The BRD SR is critical to meeting the scientific objectives of the SCC, and BRD SR faculty have made important contributions to numerous program-specific research projects (described in the Research Strategy section). In 2016, 24 (46%) of the total number of BRD SR users (52) were SCC members with peer-reviewed support. The BRD SR also served eight SCC members without peer-reviewed support. SCC members constituted 62% of the total users of the facility, highlighting the high utilization and impact that the facility has on advancing research at the SCC. During 2016, the BRD SR supported 93 total projects, 63 new and 30 ongoing. Since 2012, the BRD SR has provided biostatistical consultation services to more than half of the SCC's current 96 full and associate members.