Biostatistics and Research Design Shared Resource

生物统计学和研究设计共享资源

• 批准号: 10177890
• 负责人: Sara Katherine Vesely
• 金额: $ 16.61万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177890
• 关键词: Area; Basic Science; Biometry; Biostatistical Methods; Biostatistics Shared Resource; Cancer Center; Cancer Center Support Grant; Cancer Control; Clinical; Clinical Protocols; Clinical Research; Consultations; Data; Data Analyses; Data Collection; Development; Doctor of Philosophy; Ensure; Epidemiology; Faculty; Floor; Funding; Grant; Malignant Neoplasms; Manuscripts; Meta-Analysis; Monitor; Observational Study; Outcome; Peer Review; Phase; Policies; Preparation; Productivity; Protocols documentation; Public Health; Random Allocation; Randomized Clinical Trials; Reporting; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Sample Size; Scheme; Services; Statistical Data Interpretation; Training and Education; Universities; cancer prevention; college; community based participatory research; design; experimental study; innovation; investigator-initiated trial; meetings; member; pilot trial; programs; statistics

BIOSTATISTICS AND RESEARCH DESIGN SHARED RESOURCE – ABSTRACT The Biostatistics and Research Design Shared Resource (BRD SR) at the Stephenson Cancer Center (SCC) is an SCC-managed facility, under the direction of Sara Vesely, PhD, which provides SCC members with statistical assistance for a variety of projects, including basic science experiments, meta-analyses, secondary data analysis, observational studies, qualitative studies, community research, pilot trials, randomized clinical trials and early-phase investigator-initiated trials (IITs). Major consultative services provided by BRD SR faculty include assistance with refining aims and outcomes, appropriate study design selection, data collection planning, development of statistical analysis and data monitoring plans, creation of random allocation schemes, sample size calculations and grant preparation. BRD SR faculty also provide data analysis support across the full spectrum of cancer-related research, including preliminary data for grant submissions, pilot data analysis and abstract and manuscript preparation. BRD SR faculty serve on a variety of SCC committees (e.g., PRMC, DSMC) to assist with all aspects of protocol review and monitoring to ensure rigor and reproducibility. In 2016, the BRD SR had six faculty biostatisticians (2.05 total funded FTE) and three GRA support staff. BRD SR faculty and staff meet twice monthly in a standing meeting, chaired by Dr. Vesely, to discuss administrative policies and operational issues. To facilitate access, the BRD SR has dedicated office space in the Peggy and Charles Stephenson Cancer Center building (fifth floor), which is the SCC's main clinical and administrative building, and in University Research Park (fourth floor), which houses the SCC's Cancer Prevention and Control program. The academic offices for the BRD SR biostatistics faculty are located in the Department of Biostatistics and Epidemiology (BSE) in the OU College of Public Health building. The BRD SR is critical to meeting the scientific objectives of the SCC, and BRD SR faculty have made important contributions to numerous program-specific research projects (described in the Research Strategy section). In 2016, 24 (46%) of the total number of BRD SR users (52) were SCC members with peer-reviewed support. The BRD SR also served eight SCC members without peer-reviewed support. SCC members constituted 62% of the total users of the facility, highlighting the high utilization and impact that the facility has on advancing research at the SCC. During 2016, the BRD SR supported 93 total projects, 63 new and 30 ongoing. Since 2012, the BRD SR has provided biostatistical consultation services to more than half of the SCC's current 96 full and associate members.

生物统计和研究设计共享资源 - 摘要 斯蒂芬森癌症中心 (SCC) 的生物统计和研究设计共享资源 (BRD SR) 是 SCC 管理的机构，在 Sara Vesely 博士的指导下，为 SCC 成员提供 为各种项目提供统计援助，包括基础科学实验、荟萃分析、中学 数据分析、观察性研究、定性研究、社区研究、试点试验、随机临床 试验和早期研究者发起的试验（IIT）。 BRD SR教师提供的主要咨询服务 包括协助完善目标和结果、适当的研究设计选择、数据收集 规划、制定统计分析和数据监测计划、创建随机分配 计划、样本量计算和赠款准备。 BRD SR教师还提供数据分析支持 涵盖与癌症相关的所有研究，包括拨款申请的初步数据、试点数据 分析、摘要和手稿准备。 BRD SR 教师在多个 SCC 委员会中任职（例如， PRMC、DSMC）协助方案审查和监控的各个方面，以确保严谨性和可重复性。 2016 年，BRD SR 拥有 6 名生物统计学家（受资助的 FTE 总数为 2.05）和 3 名 GRA 支持人员。 BRD SR 教职员工每月举行两次常务会议，由 Vesely 博士主持，讨论行政事宜 政策和操作问题。为了方便访问，BRD SR 在佩吉和 查尔斯·史蒂芬森癌症中心大楼（五楼），是 SCC 的主要临床和行政部门 大楼和大学研究园（四楼），其中设有 SCC 的癌症预防和 控制程序。 BRD SR 生物统计学教师的学术办公室位于 OU 公共卫生学院大楼内的生物统计学和流行病学 (BSE)。 BRD SR 对于实现 SCC 的科学目标至关重要，并且 BRD SR 教师已经做出了 对许多特定计划的研究项目做出了重要贡献（在研究策略中描述） 部分）。 2016 年，BRD SR 用户总数 (52) 中有 24 名 (46%) 是经过同行评审的 SCC 成员 支持。 BRD SR 还在没有同行评审支持的情况下为八个 SCC 成员提供服务。 SCC会员 占该设施总用户的 62%，凸显了该设施的高利用率和影响力 关于推进 SCC 的研究。 2016 年期间，BRD SR 总共支持了 93 个项目，其中 63 个新项目和 30 个项目 正在进行中。自2012年以来，BRD SR已为一半以上的国家提供了生物统计咨询服务。 SCC现有96名正式会员和准会员。