Signaling and Tumor Microenvironment (STME)

信号传导和肿瘤微环境 (STME)

• 批准号: 10627253
• 负责人: Marina Pasca Di Magliano
• 金额: $ 7.85万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627253
• 关键词: Achievement; Affect; Animal Model; Area; Award; Basic Science; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Control; Cells; Clinical Research; Collaborations; Community Outreach; Data Science; Detection; Development; Developmental Therapeutics Program; Diagnosis; Diagnostic; Doctor of Philosophy; Drug Kinetics; Drug Screening; Early Diagnosis; Epithelium; Faculty; Fibroblasts; Flow Cytometry; Funding; Future; Glossary; Goals; Grant; Growth; Hematopoiesis; Heterogeneity; Homeostasis; Immune; Immunity; Immunologic Monitoring; Immunology; Inflammation; Internal Medicine; Invaded; Journals; Knowledge; Malignant Neoplasms; Mentors; Metabolic; Metabolic Pathway; Metabolism; Metabolite Interaction; Michigan; Microbe; Molecular; Names; Neoplasm Metastasis; Operative Surgical Procedures; Pathway interactions; Peer Review; Phenotype; Physiology; Population Sciences; Prevention; Proteomics; Publications; Research; Research Personnel; Research Support; Resource Sharing; Role; Scheme; Schools; Seminal; Signal Transduction; Source; Structure; Therapeutic; Tissue imaging; Tissues; Training and Education; Transgenic Animals; Translating; Translational Research; United States National Institutes of Health; Universities; Work; cancer genetics; cancer prevention; cellular imaging; college; community engagement; extracellular; health communication; improved; insight; interdisciplinary collaboration; interest; irradiation; member; microbiome; molecular imaging; molecular pathology; neoplastic cell; novel; novel marker; pre-clinical; professor; programs; recruit; single cell analysis; small molecule; stemness; therapy resistant; treatment response; tumor; tumor initiation; tumor metabolism; tumor microenvironment; tumor progression; tumorigenesis; working group

PROJECT SUMMARY/ABSTRACT (SIGNALING AND TUMOR MICROENVIRONMENT) Members of the University of Michigan (U-M) Rogel Cancer Center (Rogel) Signaling and Tumor Microenvironment (STME) Program share interests that align with five of the nine Rogel cross-cutting research themes: Tumor Microenvironment & Metabolism; Molecular Determinants; Inflammation, Microbes & Immunity; Targets & Therapeutics; and Prevention & Early Detection. STME, formerly known as the Cancer Biology (CB), was renamed to reflect the areas of strength and focus of the membership. Members of the STME Program are engaged in understanding both tumor-intrinsic and microenvironmental effects of altered signaling networks. STME Program comprises 55 members from 28 departments and four schools at the University of Michigan. STME members have $15.3M in annual cancer-relevant grant funding (DC), 88% of which comes from peer- reviewed sources (36% NCI, 44% other NIH sources). Investigators are involved in intra- and inter-programmatic interactions and actively collaborate with Rogel Cancer Center researchers within the Basic Science, Translational and Clinical Research, and Cancer Control and Population Sciences Programs. During the period of 01/01/2017 and 12/31/2021, members authored a total of 910 cancer-relevant publications, 30.7% in journals with Impact Factors > 10. The shared research interests of program members are reflected in the program’s overall scientific aims: 1) Elucidate the role of cell fate and plasticity during tissue homeostasis and cancer progression, 2) Define the heterocellular interactions that drive tumor epithelial growth and treatment response, 3) Characterize metabolic and metabolite interactions that impact cancer and growth progression. The Aims will identify cell autonomous and microenvironmental factors that alter fundamental aspects of tumor initiation, expansion, invasion and metastasis. Our main goal is to translate the mechanistic findings to improve cancer prevention, diagnosis, and treatment.

项目摘要/摘要（信号传导和肿瘤微环境） 密歇根大学 (U-M) 罗格尔癌症中心 (Rogel) 信号与肿瘤中心成员 微环境 (STME) 计划与 Rogel 九项跨领域研究中的五项有着共同的兴趣 主题：肿瘤微环境与代谢；分子决定因素；炎症、微生物和免疫； 目标与治疗；以及预防和早期检测。 STME，以前称为癌症生物学（CB）， 更名以反映成员的优势领域和重点。 STME 计划的成员是 致力于了解信号网络改变的肿瘤内在和微环境影响。 STME 项目由来自密歇根大学 28 个系和 4 个学院的 55 名成员组成。 STME 成员每年拥有 1530 万美元的癌症相关拨款 (DC)，其中 88% 来自同行 审查来源（36% NCI，44% 其他 NIH 来源）。调查人员参与计划内和计划间 与罗格尔癌症中心研究人员在基础科学领域进行互动并积极合作， 转化和临床研究、癌症控制和人口科学项目。期内 2017年1月1日至2021年12月31日期间，会员共发表了910篇癌症相关出版物，其中30.7%发表在期刊上 影响因子 > 10。项目成员的共同研究兴趣反映在项目的 总体科学目标：1）阐明细胞命运和可塑性在组织稳态和癌症中的作用 进展，2) 定义驱动肿瘤上皮生长和治疗反应的异细胞相互作用， 3) 表征影响癌症和生长进程的代谢和代谢相互作用。目标将 识别改变肿瘤发生的基本方面的细胞自主和微环境因素， 扩张、侵袭和转移。我们的主要目标是将机制发现转化为改善癌症 预防、诊断和治疗。