Training Program in Organogenesis

器官发生培训计划

• 批准号: 10152628
• 负责人: Marina Pasca Di Magliano
• 金额: $ 34.91万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-14 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10152628
• 关键词: Organogenesis; Training Programs

ABSTRACT The rapid advancement and technical changes in biomedical science requires that we identify strategies to help the next generation of scientists navigate a complex landscape in which fluent communication and collaboration between scientific disciplines is essential for success. The Center for Organogenesis (CFO) was formed in 1995 to unite basic, applied and clinical scientists with a common goal: to understand the basic mechanisms that underlie organ and tissue formation, and to use this knowledge to create long-lasting artificial organs, improve stem cell therapies and effective organ transplantation systems that will correct acquired and inherited human disease. The Training Program in Organogenesis was initiated 19 years ago as an integral part of the educational mission of the CFO. Its main goals are to provide intellectual and technical training in the field of organogenesis, and to promote interdisciplinary engagement by exposing trainees to research and research mentors that cross boundaries between clinical, basic and applied sciences. These goals are accomplished by encouraging a two-mentor structure for research training and the involvement of trainees in several training activities that include participation in a formal course in Organogenesis, an Organogenesis Seminar series, bimonthly training meetings, bi- annual International Symposia, and a regular CrossTalk series, in which we pair a clinician and basic scientist to jointly present on a common organ or disease/disorder. All trainees additionally engage in BioArtography, a community outreach program where art, science and public education are combined. Each trainee is offered the option of pairing with a clinical co- mentor who agrees to facilitate their exposure to clinical science, clinical management of patients and their health challenges in the trainee's research area. This competitive renewal requests continued funding for 5 predoctoral and 3 postdoctoral training slots (one specifically targeted to an MD fellow). Trainees come primarily from the laboratories of the 38 listed mentors of the Training Program. Participating faculty come from 15 departments and 4 schools across the University of Michigan (Medical School, College of Engineering, College of Literature, Sciences & Arts and Dental School). The Program is monitored by an internal Advisory Board and Operating Committee, and also by two External Advisors (Drs. Bradley Yoder, PhD, University of Alabama-Birmingham, and Richard Behringer, PhD, MD Anderson) to ensure its continued responsiveness to an evolving research environment.

摘要 生物医学科学的快速发展和技术变革要求我们识别 帮助下一代科学家驾驭复杂景观的战略， 科学学科之间的顺畅沟通和合作是取得成功的关键。 器官发生中心（CFO）成立于1995年，将基础，应用和临床结合起来 科学家们有一个共同的目标：了解器官的基本机制， 组织形成，并利用这些知识来创造持久的人造器官， 干细胞疗法和有效的器官移植系统，将纠正获得性和 人类遗传疾病器官发生的培训计划始于19年前 作为CFO教育使命的一个组成部分。其主要目标是提供 在器官形成领域的知识和技术培训，并促进 跨学科参与，让受训者接触研究和研究导师， 跨越临床、基础和应用科学之间的界限。这些目标是 通过鼓励研究培训的双导师结构和 受训人员参与若干培训活动，包括参加一个正式的 课程在器官发生，一个器官发生研讨会系列，双月培训会议，双月， 年度国际研讨会，和定期的相声系列，在其中我们配对临床医生 和基础科学家共同提出一个共同的器官或疾病/障碍。所有学员 此外，还参与BioArtography，这是一个社区外展计划，艺术，科学和 公共教育结合起来。每个学员都可以选择与临床合作伙伴配对， 同意促进其接触临床科学、临床管理 病人和他们的健康挑战在受训者的研究领域。这次竞争性的续约 要求继续资助5个博士前和3个博士后培训名额（一个专门 一个MD研究员）。受训人员主要来自所列38个实验室 培训计划的导师。参与的教师来自15个部门和4个 密歇根大学的所有学校（医学院，工程学院， 文学，科学和艺术和牙科学校）。该计划由内部监督 咨询委员会和运营委员会，以及两名外部顾问（布拉德利博士 约德，博士，伯明翰大学，和理查德贝林格，博士，医学博士安德森） 以确保其对不断变化的研究环境的持续响应。

项目成果

Structural rules and complex regulatory circuitry constrain expression of a Notch- and EGFR-regulated eye enhancer.

• DOI: 10.1016/j.devcel.2009.12.026
• 发表时间: 2010-03-16
• 期刊: DEVELOPMENTAL CELL
• 影响因子: 11.8
• 作者: Swanson, Christina I.;Evans, Nicole C.;Barolo, Scott
• 通讯作者: Barolo, Scott

Hedgehog signaling controls homeostasis of adult intestinal smooth muscle.

• DOI: 10.1016/j.ydbio.2011.04.025
• 发表时间: 2011-07-01
• 期刊: Developmental biology
• 影响因子: 2.7
• 作者: Zacharias WJ;Madison BB;Kretovich KE;Walton KD;Richards N;Udager AM;Li X;Gumucio DL
• 通讯作者: Gumucio DL

Scleraxis-Lineage Cells Contribute to Ectopic Bone Formation in Muscle and Tendon.

• DOI: 10.1002/stem.2515
• 发表时间: 2017-03
• 期刊: Stem cells (Dayton, Ohio)
• 作者: Agarwal S;Loder SJ;Cholok D;Peterson J;Li J;Breuler C;Cameron Brownley R;Hsin Sung H;Chung MT;Kamiya N;Li S;Zhao B;Kaartinen V;Davis TA;Qureshi AT;Schipani E;Mishina Y;Levi B
• 通讯作者: Levi B

Quantifying size and number of adipocytes in adipose tissue.

• DOI: 10.1016/b978-0-12-411619-1.00006-9
• 发表时间: 2014
• 期刊: METHODS IN ENZYMOLOGY
• 作者: Parlee, Sebastian D.;Lentz, Stephen I.;Mori, Hiroyuki;MacDougald, Ormond A.
• 通讯作者: MacDougald, Ormond A.

In Vitro Induction and In Vivo Engraftment of Lung Bud Tip Progenitor Cells Derived from Human Pluripotent Stem Cells.

• DOI: 10.1016/j.stemcr.2017.11.012
• 发表时间: 2018-01-09
• 期刊: Stem cell reports
• 影响因子: 5.9
• 作者: Miller AJ;Hill DR;Nagy MS;Aoki Y;Dye BR;Chin AM;Huang S;Zhu F;White ES;Lama V;Spence JR
• 通讯作者: Spence JR