Training Program in Organogenesis

器官发生培训计划

• 批准号: 10152628
• 负责人: Marina Pasca Di Magliano
• 金额: $ 34.91万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-14 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10152628
• 关键词: Organogenesis; Training Programs

ABSTRACT The rapid advancement and technical changes in biomedical science requires that we identify strategies to help the next generation of scientists navigate a complex landscape in which fluent communication and collaboration between scientific disciplines is essential for success. The Center for Organogenesis (CFO) was formed in 1995 to unite basic, applied and clinical scientists with a common goal: to understand the basic mechanisms that underlie organ and tissue formation, and to use this knowledge to create long-lasting artificial organs, improve stem cell therapies and effective organ transplantation systems that will correct acquired and inherited human disease. The Training Program in Organogenesis was initiated 19 years ago as an integral part of the educational mission of the CFO. Its main goals are to provide intellectual and technical training in the field of organogenesis, and to promote interdisciplinary engagement by exposing trainees to research and research mentors that cross boundaries between clinical, basic and applied sciences. These goals are accomplished by encouraging a two-mentor structure for research training and the involvement of trainees in several training activities that include participation in a formal course in Organogenesis, an Organogenesis Seminar series, bimonthly training meetings, bi- annual International Symposia, and a regular CrossTalk series, in which we pair a clinician and basic scientist to jointly present on a common organ or disease/disorder. All trainees additionally engage in BioArtography, a community outreach program where art, science and public education are combined. Each trainee is offered the option of pairing with a clinical co- mentor who agrees to facilitate their exposure to clinical science, clinical management of patients and their health challenges in the trainee's research area. This competitive renewal requests continued funding for 5 predoctoral and 3 postdoctoral training slots (one specifically targeted to an MD fellow). Trainees come primarily from the laboratories of the 38 listed mentors of the Training Program. Participating faculty come from 15 departments and 4 schools across the University of Michigan (Medical School, College of Engineering, College of Literature, Sciences & Arts and Dental School). The Program is monitored by an internal Advisory Board and Operating Committee, and also by two External Advisors (Drs. Bradley Yoder, PhD, University of Alabama-Birmingham, and Richard Behringer, PhD, MD Anderson) to ensure its continued responsiveness to an evolving research environment.

抽象的 生物医学科学的快速进步和技术变化要求我们确定 帮助下一代科学家的策略驾驶着复杂的景观 科学学科之间流利的沟通和协作对于成功至关重要。 1995年形成了器官发生中心（CFO），以团结基本，应用和临床 具有共同目标的科学家：了解器官和器官的基本机制 组织形成，并利用这些知识来创建持久的人造器官，改善 干细胞疗法和有效的器官移植系统，这些系统将纠正所获得的并 遗传的人类疾病。 19年前启动了器官发生的训练计划 作为首席财务官教育任务的组成部分。它的主要目标是提供 在器官发生领域的智力和技术培训，并促进 跨学科参与通过使学员接触研究和研究导师 临床，基础和应用科学之间的跨界。这些目标是 通过鼓励两门式结构进行研究培训和 学员参与了几项培训活动，包括参加正式 器官发生的课程，一个器官发生研讨会系列，每两个月训练会议，双 年度国际研讨会和常规的串扰系列，我们在其中配对临床医生 和基础科学家共同出现在常见器官或疾病中。所有学员 此外，还从事生物艺术学，这是一个社区外展计划，艺术，科学和 将公共教育结合在一起。为每个学员提供与临床共同配对的选项 同意促进其临床科学，临床管理的导师 患者及其健康挑战在受训人员的研究领域。这种竞争性更新 请求继续为5个五次前和3个博士后培训插槽提供资金（一个特别是一个 针对MD研究员）。学员主要来自列出的38个实验室 培训计划的导师。参加教师来自15个部门和4个部门 密歇根大学的学校（医学院，工程学院，学院，学院 文学，科学与艺术与牙科学校）。该程序由内部监视 顾问委员会和运营委员会以及两名外部顾问（布拉德利博士 Yoder，Alabama-Birmingham大学和理查德·贝林格（Richard Behringer）博士，医学博士Anderson） 确保其对不断发展的研究环境的持续响应能力。

项目成果

Sodium channel β subunits: emerging targets in channelopathies.

• DOI: 10.1146/annurev-physiol-021014-071846
• 发表时间: 2015
• 期刊: Annual review of physiology
• 影响因子: 18.2
• 作者: O'Malley HA;Isom LL
• 通讯作者: Isom LL

Plexins promote Hedgehog signaling through their cytoplasmic GAP activity.

• DOI: 10.7554/elife.74750
• 发表时间: 2022-09-28
• 期刊: eLife
• 影响因子: 7.7
• 作者: Pinskey JM;Hoard TM;Zhao XF;Franks NE;Frank ZC;McMellen AN;Giger RJ;Allen BL
• 通讯作者: Allen BL

Biochemical Basis for Dominant Inheritance, Variable Penetrance, and Maternal Effects in RBP4 Congenital Eye Disease.

• DOI: 10.1016/j.cell.2015.03.006
• 发表时间: 2015-04-23
• 期刊: Cell
• 影响因子: 64.5
• 作者: Chou CM;Nelson C;Tarlé SA;Pribila JT;Bardakjian T;Woods S;Schneider A;Glaser T
• 通讯作者: Glaser T

Understanding Progressive Multifocal Leukoencephalopathy Risk in Multiple Sclerosis Patients Treated with Immunomodulatory Therapies: A Bird's Eye View.

• DOI: 10.3389/fimmu.2018.00138
• 发表时间: 2018
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Mills EA;Mao-Draayer Y
• 通讯作者: Mao-Draayer Y

Evaluation of Salivary Cytokines for Diagnosis of both Trauma-Induced and Genetic Heterotopic Ossification.

• DOI: 10.3389/fendo.2017.00074
• 发表时间: 2017
• 期刊: Frontiers in endocrinology
• 影响因子: 5.2
• 作者: Sung Hsieh HH;Chung MT;Allen RM;Ranganathan K;Habbouche J;Cholok D;Butts J;Kaura A;Tiruvannamalai-Annamalai R;Breuler C;Priest C;Loder SJ;Li J;Li S;Stegemann J;Kunkel SL;Levi B
• 通讯作者: Levi B