Development and Neuroadaptations in Alcohol and Addictions (DNA2)

酒精和成瘾的发育和神经适应（DNA2）

• 批准号: 10628091
• 负责人: J. DAVID JENTSCH
• 金额: $ 34.41万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628091
• 关键词: Alcohols; Development; addiction; neuroadaptation

The goal of this proposal is to renew a highly successful pre- and post-doctoral training program in the area of development and neuroadaptations in alcohol and addictions (DNA2). Given increasing recognition that alcohol use disorder and other addictions have roots established in early development, the proposed training grant will provide the next generation of researchers with crucial training in the conceptual issues and methodological approaches for studying developmental neuroadaptations leading to substance use and use disorder. Building on existing research strengths in this area, exemplified by the Developmental Exposure Alcohol Research Center (DEARC), and anchored by historically strong graduate training programs in development, addictions and neuroadaptations within the Department of Psychology, the DNA2 program will provide a rich, cooperative intellectual environment conducive for highly successful research training, didactic education and mentorship for the proposed predoctoral (4/year) and postdoctoral (2/year) trainees. The training program emphasizes five key goals: (1) to actively seek and recruit a highly qualified and diverse group of pre- and post-doctoral trainees whose interest in and commitment to research in alcohol and addictions fits the laboratory(s) of one or more mentor-eligible faculty and to provide each with an individualized training experience that fosters expertise in state-of-the-art assessments, hypothesis formation, rigorous experimental design, data acquisition and analysis, and oral presentation and publication of results; (2) to create a formal training program that emphasizes breadth in conceptual knowledge and technical capabilities and fosters translational considerations; (3) to emphasize critical thinking, scientific rigor and best practices for scientists of the 21st century; and (4) to support the career/professional development of each trainee. To meet these goals, the T32 program will provide comprehensive interdisciplinary training through didactic coursework, trainee workshops, seminars/colloquia, journal and writing clubs, supervised research experiences, and participation in professional meetings and extra-university training opportunities. Methodological issues and techniques in alcohol and drug addiction research will be emphasized throughout the typical 2-year training period for each trainee, with a particular focus on training in developmental approaches, and rigorous attention to education in the responsible conduct of research, including means to enhance research reproducibility. This training program combines the expertise of faculty with established expertise in the alcohol field, as well as in research with other addictive drugs, to capitalize on synergies across research programs and perspectives.

该提案的目标是更新一个非常成功的前和博士后培训计划，在该地区的 酒精和成瘾的发展和神经适应（DNA 2）。鉴于越来越多的人认识到酒精 使用障碍和其他成瘾在早期发展中已经根深蒂固，拟议的培训补助金将 为下一代研究人员提供概念问题和方法论方面的重要培训 研究导致物质使用和使用障碍的发育神经适应的方法。建筑 这一领域现有的研究优势，例如发展暴露酒精研究 中心（DEARC），并通过历史上强大的研究生培训计划在发展，成瘾 和心理学系内的神经适应，DNA 2计划将提供一个丰富的，合作的， 有利于非常成功的研究培训、教学教育和指导的知识环境 为拟议的博士前（4/年）和博士后（2/年）学员。培训计划强调五个 主要目标：（1）积极寻找和招募一批高素质和多样化的博士前和博士后 对酒精和成瘾研究的兴趣和承诺符合一个或多个实验室的受训人员， 更多的导师合格的教师，并提供个性化的培训经验，培养每个人的 在最先进的评估，假设形成，严格的实验设计，数据采集方面的专业知识 （2）建立一个正式的培训计划， 强调概念知识和技术能力的广度， （3）强调21世纪科学家的批判性思维，科学严谨性和最佳实践 世纪;及（4）支持每名受训人员的职业/专业发展。为了实现这些目标，T32 该计划将通过教学课程，学员研讨会， 研讨会/座谈会，期刊和写作俱乐部，监督研究经验，并参加 专业会议和校外培训机会。方法学问题和技术 酒精和药物成瘾的研究将在整个典型的2年培训期内得到强调， 培训人员，特别侧重于发展方法的培训，并严格关注 负责任地进行研究，包括提高研究再现性的手段。本次培训 该计划将教师的专业知识与酒精领域的专业知识相结合，以及在研究 与其他成瘾药物，利用跨研究项目和观点的协同作用。