Development and Neuroadaptations in Alcohol and Addictions (DNA2)

酒精和成瘾的发育和神经适应（DNA2）

• 批准号: 10628091
• 负责人: J. DAVID JENTSCH
• 金额: $ 34.41万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628091
• 关键词: Alcohols; Development; addiction; neuroadaptation

The goal of this proposal is to renew a highly successful pre- and post-doctoral training program in the area of development and neuroadaptations in alcohol and addictions (DNA2). Given increasing recognition that alcohol use disorder and other addictions have roots established in early development, the proposed training grant will provide the next generation of researchers with crucial training in the conceptual issues and methodological approaches for studying developmental neuroadaptations leading to substance use and use disorder. Building on existing research strengths in this area, exemplified by the Developmental Exposure Alcohol Research Center (DEARC), and anchored by historically strong graduate training programs in development, addictions and neuroadaptations within the Department of Psychology, the DNA2 program will provide a rich, cooperative intellectual environment conducive for highly successful research training, didactic education and mentorship for the proposed predoctoral (4/year) and postdoctoral (2/year) trainees. The training program emphasizes five key goals: (1) to actively seek and recruit a highly qualified and diverse group of pre- and post-doctoral trainees whose interest in and commitment to research in alcohol and addictions fits the laboratory(s) of one or more mentor-eligible faculty and to provide each with an individualized training experience that fosters expertise in state-of-the-art assessments, hypothesis formation, rigorous experimental design, data acquisition and analysis, and oral presentation and publication of results; (2) to create a formal training program that emphasizes breadth in conceptual knowledge and technical capabilities and fosters translational considerations; (3) to emphasize critical thinking, scientific rigor and best practices for scientists of the 21st century; and (4) to support the career/professional development of each trainee. To meet these goals, the T32 program will provide comprehensive interdisciplinary training through didactic coursework, trainee workshops, seminars/colloquia, journal and writing clubs, supervised research experiences, and participation in professional meetings and extra-university training opportunities. Methodological issues and techniques in alcohol and drug addiction research will be emphasized throughout the typical 2-year training period for each trainee, with a particular focus on training in developmental approaches, and rigorous attention to education in the responsible conduct of research, including means to enhance research reproducibility. This training program combines the expertise of faculty with established expertise in the alcohol field, as well as in research with other addictive drugs, to capitalize on synergies across research programs and perspectives.

该提案的目标是在以下领域更新一个非常成功的博士前和博士后培训计划 酒精和成瘾的发育和神经适应（DNA2）。鉴于人们越来越认识到酒精 使用障碍和其他成瘾现象的根源在于早期发展，拟议的培训补助金将 为下一代研究人员提供概念问题和方法论方面的重要培训 研究导致物质使用和使用障碍的发育神经适应的方法。建筑 该领域现有的研究优势，例如发展暴露酒精研究 中心（DEARC），以历史悠久的发展、成瘾方面的研究生培训项目为基础 和心理学系内的神经适应，DNA2 计划将提供丰富的、合作的 有利于取得巨大成功的研究培训、教学教育和指导的智力环境 针对拟招收的博士前（4人/年）和博士后（2人/年）学员。培训计划强调五点 主要目标：（1）积极寻找和招募一支高素质、多元化的博士前和博士后群体 对酒精和成瘾研究感兴趣并致力于研究的受训者适合一个或多个实验室 更多符合导师资格的教师，并为每个人提供个性化的培训经验，以促进 最先进的评估、假设形成、严格的实验设计、数据采集方面的专业知识 分析、口头陈述和结果发布； (2) 制定正式的培训计划 强调概念知识和技术能力的广度，并促进转化 考虑因素； (3) 强调21世纪科学家的批判性思维、科学严谨性和最佳实践 世纪; (4) 支持每位学员的职业/专业发展。为了实现这些目标，T32 计划将通过教学课程、实习生讲习班提供全面的跨学科培训， 研讨会/座谈会、期刊和写作俱乐部、监督研究经验以及参与 专业会议和校外培训机会。方法论问题和技术 在每个人的典型 2 年培训期间，将强调酒精和毒瘾研究 受训者，特别注重发展方法的培训，并严格关注教育 负责任地进行研究，包括提高研究可重复性的方法。本次培训 该计划将教师的专业知识与酒精领域以及研究领域的既定专业知识相结合 与其他成瘾药物一起，利用研究项目和观点之间的协同作用。