DEARC - Pilot Core Projects

DEARC - 试点核心项目

• 批准号: 10470014
• 负责人: J. DAVID JENTSCH
• 金额: $ 6.16万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10470014
• 关键词: Advisory Committees; Alcohol consumption; Alcohols; Amniotic Fluid; Area; Award; Behavior; Budgets; Collaborations; Communities; Contracts; Development; Direct Costs; Effectiveness; Ethanol; Extinction (Psychology); Extramural Activities; Faculty; Fetal Alcohol Syndrome; Fetal Development; Fostering; Fright; Funding; Funding Mechanisms; Future; Goals; Grant; Growth; Impairment; Incubators; Institution; Lead; Maintenance; Medial; Mediating; Medical; Mentors; Mission; Modeling; Molecular; Monitor; Mothers; Mus; National Institute on Alcohol Abuse and Alcoholism; Pilot Projects; Play; Prefrontal Cortex; Process; Program Reviews; Rattus; Reporting; Research; Research Personnel; Research Priority; Research Project Grants; Resources; Role; Science; Scientist; Seasons; Seeds; Small RNA; Structure; Talents; Testing; Time; United States National Institutes of Health; Universities; Work; alcohol effect; alcohol exposure; alcohol research; base; career; college; exosome; innovation; interest; intergenerational; member; neuroadaptation; neurobehavioral; novel; offspring; peer; post-doctoral training; pre-clinical; programs; psychologic; relating to nervous system; senior faculty; synergism; technology development; transmission process

PROJECT SUMMARY/ABSTRACT PILOT PROJECT CORE The goals of the Pilot Project Core are to (1) provide a structured funding mechanism to seed the development of new ideas, collaborative teams or technical approaches relevant to the central themes of the DEARC; (ii) support career growth for both young and seasoned investigators through mentoring and facilitated collaboration; and (iii) capitalize on unique and timely opportunities that may arise from the rapidly changing, dynamic field of research on alcohol and development. The Pilot Project Core will achieve these goals through administration of a Pilot Project program that solicits Pilot Project Proposals from eligible investigators, coordinates the review process for proposals received, and ultimately oversees the award and reporting functions for all supported Pilot Projects. In addition, the Pilot Project Core, in close collaboration with the Executive Committee, will help promote scientific connections among new members of the DEARC, and between these new members and established DEARC investigators to further increase scientific synergy and promote both peer-based and mentor-mentee relationships within the Center. Pilot Projects will be supported for 1-2 years each and will be funded at $45K (direct costs) per year. Using this approach, we will have at least 6 funded pilot projects during the proposed 5-year funding period. Two highly innovative Pilot Project proposals are proposed to begin in the first budget year of this Center. Pilot Project 1 (Middleton, PI) will lay the groundwork for research that will determine the novel role for exosome-mediated delivery of small RNAs from ethanol-treated dams to offspring via amniotic fluid, representing a novel mechanism for inter-generational transmission of ethanol effects. Pilot Project 2 (Bergstrom, PI) will 1) evaluate the developmentally-specific effect of voluntary alcohol intake on the ability to suppress conditional fear behavior after extinction of the learned associations and 2) utilize chemogenetic approaches to test the functional significance of impaired neural activity in the medial prefrontal cortex on this effect. Future projects will similarly promote the Center's scientific mission through novel technical and conceptual advances. Through support of exciting new projects and investigators, novel collaborative ventures and technology development efforts, the Pilot Project Core will serve as an incubator of great new ideas and teams that will positively contribute to the mission of the DEARC.

项目摘要/摘要 飞行员项目核心 试点项目核心的目标是（1）提供结构化的资金机制来播种开发 与Dearc的中心主题相关的新想法，协作团队或技术方法； （ii） 通过指导和促进 合作; （iii）利用迅速变化的独特和及时的机会， 酒精与开发研究的动态研究领域。飞行员项目核心将通过 执行试点项目计划，该计划征求合格调查人员的试点项目建议， 协调收到的提案的审核过程，并最终监督奖项和报告 所有受支持的试点项目的功能。此外，飞行员项目核心与 执行委员会将有助于促进Dearc新成员之间的科学联系，并 在这些新成员和已建立的Dearc研究人员之间，以进一步提高科学协同作用和 在中心内促进基于同伴和导师的关系。试点项目将得到支持 每人1-2年，每年将以$ 45K（直接费用）的资金提供资金。使用这种方法，我们至少有 在拟议的5年资金期间，有6个资助的试点项目。两个高度创新的试点项目建议 建议从该中心的第一年开始。飞行员项目1（Middleton，pi）将放置 研究的基础工作将决定外泌体介导的小RNA从 乙醇处理的大坝通过羊水到后代，代表一种新的机制 乙醇效应的传播。试点项目2（Bergstrom，PI）将1）评估特定于发育的特定 自愿性酒精摄入量对抑制有条件恐惧行为的能力的影响 学识渊博的关联和2）利用化学遗传方法来测试受损的功能意义 内侧前额叶皮层中的神经活动对此作用。未来的项目将同样促进该中心的 通过新颖的技术和概念进步的科学任务。通过支持激动人心的新项目 以及调查人员，新颖的合作企业和技术开发工作，飞行员项目核心将 充当伟大的新想法和团队的孵化器，将对Dearc的使命做出积极贡献。