DEARC - Pilot Core Projects

DEARC - 试点核心项目

• 批准号: 10470014
• 负责人: J. DAVID JENTSCH
• 金额: $ 6.16万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10470014
• 关键词: Advisory Committees; Alcohol consumption; Alcohols; Amniotic Fluid; Area; Award; Behavior; Budgets; Collaborations; Communities; Contracts; Development; Direct Costs; Effectiveness; Ethanol; Extinction (Psychology); Extramural Activities; Faculty; Fetal Alcohol Syndrome; Fetal Development; Fostering; Fright; Funding; Funding Mechanisms; Future; Goals; Grant; Growth; Impairment; Incubators; Institution; Lead; Maintenance; Medial; Mediating; Medical; Mentors; Mission; Modeling; Molecular; Monitor; Mothers; Mus; National Institute on Alcohol Abuse and Alcoholism; Pilot Projects; Play; Prefrontal Cortex; Process; Program Reviews; Rattus; Reporting; Research; Research Personnel; Research Priority; Research Project Grants; Resources; Role; Science; Scientist; Seasons; Seeds; Small RNA; Structure; Talents; Testing; Time; United States National Institutes of Health; Universities; Work; alcohol effect; alcohol exposure; alcohol research; base; career; college; exosome; innovation; interest; intergenerational; member; neuroadaptation; neurobehavioral; novel; offspring; peer; post-doctoral training; pre-clinical; programs; psychologic; relating to nervous system; senior faculty; synergism; technology development; transmission process

PROJECT SUMMARY/ABSTRACT PILOT PROJECT CORE The goals of the Pilot Project Core are to (1) provide a structured funding mechanism to seed the development of new ideas, collaborative teams or technical approaches relevant to the central themes of the DEARC; (ii) support career growth for both young and seasoned investigators through mentoring and facilitated collaboration; and (iii) capitalize on unique and timely opportunities that may arise from the rapidly changing, dynamic field of research on alcohol and development. The Pilot Project Core will achieve these goals through administration of a Pilot Project program that solicits Pilot Project Proposals from eligible investigators, coordinates the review process for proposals received, and ultimately oversees the award and reporting functions for all supported Pilot Projects. In addition, the Pilot Project Core, in close collaboration with the Executive Committee, will help promote scientific connections among new members of the DEARC, and between these new members and established DEARC investigators to further increase scientific synergy and promote both peer-based and mentor-mentee relationships within the Center. Pilot Projects will be supported for 1-2 years each and will be funded at $45K (direct costs) per year. Using this approach, we will have at least 6 funded pilot projects during the proposed 5-year funding period. Two highly innovative Pilot Project proposals are proposed to begin in the first budget year of this Center. Pilot Project 1 (Middleton, PI) will lay the groundwork for research that will determine the novel role for exosome-mediated delivery of small RNAs from ethanol-treated dams to offspring via amniotic fluid, representing a novel mechanism for inter-generational transmission of ethanol effects. Pilot Project 2 (Bergstrom, PI) will 1) evaluate the developmentally-specific effect of voluntary alcohol intake on the ability to suppress conditional fear behavior after extinction of the learned associations and 2) utilize chemogenetic approaches to test the functional significance of impaired neural activity in the medial prefrontal cortex on this effect. Future projects will similarly promote the Center's scientific mission through novel technical and conceptual advances. Through support of exciting new projects and investigators, novel collaborative ventures and technology development efforts, the Pilot Project Core will serve as an incubator of great new ideas and teams that will positively contribute to the mission of the DEARC.

项目概要/摘要 试点项目核心 试点项目核心的目标是 (1) 提供结构化融资机制来推动发展 与 DEARC 中心主题相关的新想法、协作团队或技术方法； (二) 通过指导和促进，支持年轻和经验丰富的研究人员的职业发展 合作; (iii) 利用快速变化中可能出现的独特且及时的机会， 酒精和发展的动态研究领域。试点项目核心将通过以下方式实现这些目标 管理试点项目计划，向合格的研究人员征求试点项目提案， 协调收到的提案的审查流程，并最终监督授予和报告 所有支持的试点项目的功能。此外，试点项目核心与 执行委员会将帮助促进 DEARC 新成员之间的科学联系，以及 这些新成员和已成立的 DEARC 研究人员之间的合作，进一步增强科学协同作用 促进中心内的同伴关系和导师与受训者关系。将支持试点项目 每个为期 1-2 年，每年的资助金额为 45,000 美元（直接费用）。使用这种方法，我们至少可以得到 在拟议的 5 年资助期内资助了 6 个试点项目。两个高度创新的试点项目提案 建议在该中心的第一个预算年开始。试点项目 1（米德尔顿，PI）将奠定 确定外泌体介导的小RNA递送的新作用的研究基础 经过乙醇处理的母鼠通过羊水传给后代，代表了一种新的代际机制 乙醇效应的传播。试点项目 2（Bergstrom，PI）将 1) 评估特定于发展的 自愿饮酒对抑制条件性恐惧行为能力的影响 习得性关联；2）利用化学遗传学方法来测试受损的功能意义 内侧前额皮质的神经活动对此有影响。未来的项目将同样促进该中心的 通过新颖的技术和概念进步实现科学使命。通过支持令人兴奋的新项目 和研究人员、新颖的合作企业和技术开发工作，试点项目核心将 作为伟大新思想和团队的孵化器，将为 DEARC 的使命做出积极贡献。