DEARC - Pilot Core Projects

项目概要/摘要 试点项目核心 核心试点项目的目标是（1）提供一个结构化的筹资机制， 与《荒漠化公约》中心主题有关的新想法、合作小组或技术方法; ㈡ 通过指导和促进，支持年轻和经验丰富的调查人员的职业发展 合作;以及（iii）利用快速变化， 酒精研究和发展的动态领域。核心试点项目将通过以下方式实现这些目标： 管理向合格的研究者征集试点项目建议书的试点项目计划， 协调对收到的提案的审查过程，并最终监督授予和报告 支持所有试点项目。此外，核心试点项目与联合国开发计划署密切合作， 执行委员会，将有助于促进DEARC新成员之间的科学联系， 这些新成员和已建立的DEARC研究人员之间，以进一步提高科学的协同作用， 促进中心内的同伴关系和导师-学员关系。试点项目将得到支持 每个项目为期1-2年，每年的直接费用为4.5万美元。使用这种方法，我们将至少 在拟议的5年供资期内资助6个试点项目。两个极具创新性的试点项目提案 建议在该中心的第一个预算年度开始开始。试点项目1（米德尔顿，PI）将奠定 为研究奠定基础，这将确定外泌体介导的小RNA递送的新作用， 乙醇处理的母鼠通过羊水传给后代，代表了一种新的代际遗传机制。 乙醇的影响。试点项目2（Bergstrom，PI）将1）评估特定于发展的 自愿饮酒对消除条件性恐惧行为后抑制条件性恐惧行为能力的影响 学习协会和2）利用化学发生学的方法来测试受损的功能意义 内侧前额叶皮层的神经活动对这种效应的影响。未来的项目将同样促进中心的 科学使命通过新的技术和概念的进步。通过支持令人兴奋的新项目 和调查人员，新的合作企业和技术开发工作，试点项目核心将 作为一个伟大的新思想和团队的孵化器，将积极贡献的DEARC的使命。

PROJECT SUMMARY/ABSTRACT PILOT PROJECT CORE The goals of the Pilot Project Core are to (1) provide a structured funding mechanism to seed the development of new ideas, collaborative teams or technical approaches relevant to the central themes of the DEARC; (ii) support career growth for both young and seasoned investigators through mentoring and facilitated collaboration; and (iii) capitalize on unique and timely opportunities that may arise from the rapidly changing, dynamic field of research on alcohol and development. The Pilot Project Core will achieve these goals through administration of a Pilot Project program that solicits Pilot Project Proposals from eligible investigators, coordinates the review process for proposals received, and ultimately oversees the award and reporting functions for all supported Pilot Projects. In addition, the Pilot Project Core, in close collaboration with the Executive Committee, will help promote scientific connections among new members of the DEARC, and between these new members and established DEARC investigators to further increase scientific synergy and promote both peer-based and mentor-mentee relationships within the Center. Pilot Projects will be supported for 1-2 years each and will be funded at $45K (direct costs) per year. Using this approach, we will have at least 6 funded pilot projects during the proposed 5-year funding period. Two highly innovative Pilot Project proposals are proposed to begin in the first budget year of this Center. Pilot Project 1 (Middleton, PI) will lay the groundwork for research that will determine the novel role for exosome-mediated delivery of small RNAs from ethanol-treated dams to offspring via amniotic fluid, representing a novel mechanism for inter-generational transmission of ethanol effects. Pilot Project 2 (Bergstrom, PI) will 1) evaluate the developmentally-specific effect of voluntary alcohol intake on the ability to suppress conditional fear behavior after extinction of the learned associations and 2) utilize chemogenetic approaches to test the functional significance of impaired neural activity in the medial prefrontal cortex on this effect. Future projects will similarly promote the Center's scientific mission through novel technical and conceptual advances. Through support of exciting new projects and investigators, novel collaborative ventures and technology development efforts, the Pilot Project Core will serve as an incubator of great new ideas and teams that will positively contribute to the mission of the DEARC.