DEARC - Pilot Core Projects

项目摘要/摘要 试点项目核心 试点项目核心项目的目标是：(1)提供结构化的资金机制，为发展提供种子 提出与解除武装冲突中心主题有关的新想法、合作小组或技术办法； 通过指导和协助，支持年轻和经验丰富的调查人员的职业成长 合作；以及(Iii)利用快速变化的、 酒精研究与发展的动态领域。试点项目核心将通过以下方式实现这些目标 管理试点项目方案，向符合条件的调查人员征求试点项目建议书； 协调收到的建议书的审查过程，并最终监督授标和报告 所有支持的试点项目的功能。此外，试点项目核心与 将有助于促进分会新成员之间的科学联系，以及 这些新成员和现有的解除弧线调查人员之间的合作，以进一步加强科学协同和 在中心内促进基于同伴和导师-被辅导者的关系。支持试点项目 为期1-2年，每年将获得45K美元(直接费用)的资助。使用这种方法，我们将至少有 在拟议的5年资金期内资助了6个试点项目。两个极具创新性的试点项目提案 建议从该中心的第一个预算年度开始。试点项目1(米德尔顿，PI)将为 为确定外切体介导的小RNA传递的新作用的研究奠定基础 乙醇处理的母鼠通过羊水传播后代，代表了一种新的代际遗传机制 酒精效应的传递。试点项目2(Bergstrom，PI)将1)评估特定于发展的 自愿饮酒对大鼠灭绝后抑制条件性恐惧行为能力的影响 学习的联想和2)利用化学遗传学方法来测试受损的功能意义 内侧前额叶皮质的神经活动对此有影响。未来的项目将同样促进该中心的 通过新的技术和概念进步实现科学使命。通过支持激动人心的新项目 和调查人员、新的合作企业和技术开发努力，试点项目核心将 作为伟大的新想法和团队的孵化器，这些想法和团队将为DARC的使命做出积极贡献。

PROJECT SUMMARY/ABSTRACT PILOT PROJECT CORE The goals of the Pilot Project Core are to (1) provide a structured funding mechanism to seed the development of new ideas, collaborative teams or technical approaches relevant to the central themes of the DEARC; (ii) support career growth for both young and seasoned investigators through mentoring and facilitated collaboration; and (iii) capitalize on unique and timely opportunities that may arise from the rapidly changing, dynamic field of research on alcohol and development. The Pilot Project Core will achieve these goals through administration of a Pilot Project program that solicits Pilot Project Proposals from eligible investigators, coordinates the review process for proposals received, and ultimately oversees the award and reporting functions for all supported Pilot Projects. In addition, the Pilot Project Core, in close collaboration with the Executive Committee, will help promote scientific connections among new members of the DEARC, and between these new members and established DEARC investigators to further increase scientific synergy and promote both peer-based and mentor-mentee relationships within the Center. Pilot Projects will be supported for 1-2 years each and will be funded at $45K (direct costs) per year. Using this approach, we will have at least 6 funded pilot projects during the proposed 5-year funding period. Two highly innovative Pilot Project proposals are proposed to begin in the first budget year of this Center. Pilot Project 1 (Middleton, PI) will lay the groundwork for research that will determine the novel role for exosome-mediated delivery of small RNAs from ethanol-treated dams to offspring via amniotic fluid, representing a novel mechanism for inter-generational transmission of ethanol effects. Pilot Project 2 (Bergstrom, PI) will 1) evaluate the developmentally-specific effect of voluntary alcohol intake on the ability to suppress conditional fear behavior after extinction of the learned associations and 2) utilize chemogenetic approaches to test the functional significance of impaired neural activity in the medial prefrontal cortex on this effect. Future projects will similarly promote the Center's scientific mission through novel technical and conceptual advances. Through support of exciting new projects and investigators, novel collaborative ventures and technology development efforts, the Pilot Project Core will serve as an incubator of great new ideas and teams that will positively contribute to the mission of the DEARC.