Development and Neuroadaptations in Alcohol and Addiction

酒精和成瘾的发育和神经适应

• 批准号: 10166730
• 负责人: J. DAVID JENTSCH
• 金额: $ 25.59万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10166730
• 关键词: Alcohols; Development; addiction; neuroadaptation

ABSTRACT The goal of this proposal is to support a new pre- and post-doctoral training program in the area of development and neuroadaptations in alcohol and addictions (DNA2). Given increasing recognition that alcoholism and other substance use disorders have roots established in development, the proposed training grant will provide the next generation of addiction researchers with crucial training in the conceptual issues and methodological approaches for studying developmental neuroadaptations leading to abuse and addiction. Building on existing research strengths in this area exemplified by the Developmental Exposure Alcohol Research Center (DEARC) and anchored by historically strong graduate training programs in development, addictions and neuroadaptations within psychological sciences along with rapidly evolving programs in community science and public affairs, the DNA2 T32 provides the rich, cooperative intellectual environment conducive for highly successful research training, didactic education and mentorship for the proposed predoctoral (4/yr) and postdoctoral (2/yr) trainees. The training program emphasizes five key goals: (1) to actively seek and recruit a highly qualified and diverse group of pre- and post-doctoral trainees whose interest in and commitment to research in alcohol and addictions fits the laboratory(s) of one or more mentor-eligible faculty; (2) to provide individualized training experiences that foster expertise in state-of-the-art assessments, hypothesis formation, rigorous experimental design, data acquisition and analysis, and oral presentation and publication of results; (3) to assist trainees in generating preliminary data, novel hypotheses and specific aims and provide training in writing and grantsmanship for individual grant or F31/32 fellowship applications; (4) to create an individualized, multi-level research training environment that encourages both expertise and breadth in conceptual knowledge and technical capabilities and fosters translational considerations; and (5) to support the career/professional development of each trainee. To meet these goals, the T32 program will provide comprehensive interdisciplinary training through didactic coursework, trainee workshops, seminars/colloquia, journal and writing clubs, supervised research experiences, and participation in professional meetings and extra-university training opportunities. Methodological issues and techniques in alcohol and drug abuse research will be emphasized throughout the typical 2-year training period for each trainee, with a particular focus on training in developmental approaches, and rigorous attention to education in the responsible conduct of research, including means to enhance research reproducibility. This training program combines the expertise of faculty with established expertise in the alcohol field as well as in research with other drugs of abuse to capitalize on synergies across research programs and perspectives.

摘要 该提案的目标是支持一个新的博士前和博士后培训计划， 酒精和成瘾的发展和神经适应（DNA 2）。鉴于人们日益认识到， 酗酒和其他物质使用障碍的根源建立在发展，拟议的培训， 格兰特将为下一代成瘾研究人员提供概念问题的关键培训， 研究导致滥用和成瘾的发展性神经适应的方法学途径。 建立在这一领域现有的研究优势，例如发展中国家的酒精暴露 研究中心（DEARC）和历史上强大的研究生培训计划在发展锚定， 心理科学中的成瘾和神经适应沿着快速发展的项目， 社区科学和公共事务，DNA 2 T32提供了丰富的，合作的智力环境 有利于非常成功的研究培训，教学教育和导师的建议 博士前（4/yr）和博士后（2/yr）学员。培训计划强调五个关键目标：（1） 积极寻找和招募一批高素质和多样化的博士前和博士后学员，他们的兴趣 在酒精和成瘾的研究和承诺适合一个或多个导师合格的实验室（S） 教师;（2）提供个性化的培训经验，培养最先进的评估专业知识， 假设形成，严格的实验设计，数据采集和分析，以及口头报告， 公布结果;（3）协助受训人员提出初步数据、新的假设和具体目标 并为个人赠款或F31/32研究金申请提供书面和赠款培训;（4） 创造个性化、多层次的研究培训环境，鼓励专业知识和广度 在概念知识和技术能力，并促进翻译的考虑;和（5）支持 每个学员的职业/专业发展。为了实现这些目标，T32计划将提供 通过教学课程、学员讲习班、研讨会/座谈会， 期刊和写作俱乐部，监督研究经验，并参加专业会议， 大学外的培训机会。酗酒和药物滥用方面的方法问题和技巧 研究将在每个受训人员典型的2年培训期内得到强调， 注重发展方法的培训，并高度重视负责任行为的教育 包括提高研究重复性的手段。该培训计划结合了 在酒精领域以及与其他药物的研究方面具有既定专业知识的教师的专业知识， 滥用，以利用跨研究计划和观点的协同作用。