Training Program in Rheumatic and Musculoskeletal Diseases Research

项目摘要 风湿性和肌肉骨骼疾病研究的UAB培训计划（主任：约翰D。医学博士蒙茨， 联合主任：Kenneth Saag，MD，MSc;副主任：Andre Ballesteros，PhD）建立在 在成人和儿童风湿病学、免疫学、肌肉骨骼医学方面的长期优势，以及我们的 在早期和后期阶段的翻译研究的专业知识。在过去的5年里，我们建立了一个 一个非常成功的项目，拥有一群优秀的核心导师，一个全面而灵活的培训计划， 以及来自不同背景的基础和临床学员的平衡组合。在这次重新提交的 申请，我们寻求继续专注于高素质的博士预科和 博士后（博士，医学博士/博士，或医学博士）学员谁致力于生物医学研究的职业生涯，将服务于 NIAMS的使命。该计划汇集了临床免疫学和流变学的部门 和儿科流变学，综合关节炎，肌肉骨骼，骨骼和自身免疫中心 （CAMBAC）和其他直接相关部门和计划提供一个充满活力和有效的 跨学科的培训环境。拟议的研究培训计划将继续加强 合作科学的综合、交织结构，从基础分子发现到 应用临床和转化研究。它包括一个建立，资金充足的教师致力于培训 风湿性和肌肉骨骼疾病（RMD）。我们围绕三个群体组织了我们的节目， 导师代表UAB的不同部门和项目：1。核心导师：已设立， 由外部（主要是NIH）资助的研究人员，他们的项目集中在致力于培训 下一代研究人员; 2。内容导师：a）具有RMD专业知识的临床医生或研究人员，但 其作用主要是支持性的;或在与之互补或协同的领域获得研究资金， RMD;和3.培训导师：将发展成为杰出研究的早期职业教师 导师，以进一步加强RMD研究环境。学员将根据他们对以下方面的承诺进行挑选： 研究和学术医学，UAB培训教师的成员完全致力于继续 为更多的年轻调查人员提供指导，支持和指导，帮助他们发展成为 独立的研究人员，他们将促进我们对RMD的了解。UAB流变学T32程序反映了 一个重点突出，相关，多学科的翻译研究培训计划在UAB。我们的培训计划 聚集了一个杰出的科学导师的核心，是唯一准备和坚定地致力于培训 下一代风湿性和肌肉骨骼疾病研究人员，并产生相关的知识， NIAMS和国家的使命和优先事项。

PROJECT SUMMARY The UAB Training Program in Rheumatic and Musculoskeletal Disease Research (Director: John D. Mountz, MD, PhD; co-Director: Kenneth Saag, MD, MSc; and Associate Director: Andre Ballesteros, PhD) is built on the longstanding strengths in adult and pediatric rheumatology, immunology, musculoskeletal medicine, and our expertise in both early and later phase translational investigation. Over a past 5 year funding period, we built a highly successful program with an outstanding group of core mentors, a comprehensive and flexible training plan, and a balanced mix of basic and clinical trainees from a diverse set of backgrounds. In this resubmission application, we seek to continue to focus on training and career development of highly qualified pre-doctoral and postdoctoral (PhD, MD/PhD, or MD) trainees who are committed to careers in biomedical research that will serve the mission of NIAMS. This program has brought together the Divisions of Clinical Immunology and Rheumatology and Pediatric Rheumatology, the Comprehensive Arthritis, Musculoskeletal, Bone, and Autoimmunity Center (CAMBAC), and other directly relevant departments and programs to provide a vibrant and effective interdisciplinary training environment. The proposed research training program will continue to enhance the integrated, interwoven fabric of collaborative science, which ranges from fundamental molecular discovery to applied clinical and translational research. It incorporates an established, well-funded faculty committed to training in rheumatic and musculoskeletal diseases (RMDs). We have organized our program around three groups of mentors represent a diverse set of UAB Departments and Programs at UAB: 1. Core Mentors: established, extramurally (primarily NIH) funded investigators with programs focused on RMDs committed to training the next generation of researchers; 2. Content Mentors: a) clinicians or researchers with expertise in RMDs but whose role is primarily supportive; or with research funding in areas complementary to, or synergistic with, RMDs; and 3. Mentors in Training: Early career faculty who will be developed into outstanding research mentors to further strengthen the RMD research environment. Trainees will be selected for their commitment to research and academic medicine, and the members of the UAB training faculty are fully committed to continuing to provide mentorship, support, and guidance to additional young investigators to help them develop into independent researchers who will advance our knowledge of RMDs. The UAB Rheumatology T32 program reflects a focused, relevant, multi-disciplinary translational research training program at UAB. Our training program has assembled an outstanding core of scientific mentors and is uniquely prepared and strongly committed to training of the next generation of rheumatic and musculoskeletal disease investigators and generate knowledge relevant to the mission and priorities of the NIAMS and the nation.