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Training Program in Rheumatic and Musculoskeletal Diseases Research

风湿病和肌肉骨骼疾病研究培训计划

基本信息

批准号：
10628089
负责人：
John D Mountz
金额：
$ 35.42万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-01 至 2028-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10628089
关键词：
Musculoskeletal Diseases Research Rheumatism Training Programs

项目摘要

PROJECT SUMMARY The UAB Training Program in Rheumatic and Musculoskeletal Disease Research (Director: John D. Mountz, MD, PhD; co-Director: Kenneth Saag, MD, MSc; and Associate Director: Andre Ballesteros, PhD) is built on the longstanding strengths in adult and pediatric rheumatology, immunology, musculoskeletal medicine, and our expertise in both early and later phase translational investigation. Over a past 5 year funding period, we built a highly successful program with an outstanding group of core mentors, a comprehensive and flexible training plan, and a balanced mix of basic and clinical trainees from a diverse set of backgrounds. In this resubmission application, we seek to continue to focus on training and career development of highly qualified pre-doctoral and postdoctoral (PhD, MD/PhD, or MD) trainees who are committed to careers in biomedical research that will serve the mission of NIAMS. This program has brought together the Divisions of Clinical Immunology and Rheumatology and Pediatric Rheumatology, the Comprehensive Arthritis, Musculoskeletal, Bone, and Autoimmunity Center (CAMBAC), and other directly relevant departments and programs to provide a vibrant and effective interdisciplinary training environment. The proposed research training program will continue to enhance the integrated, interwoven fabric of collaborative science, which ranges from fundamental molecular discovery to applied clinical and translational research. It incorporates an established, well-funded faculty committed to training in rheumatic and musculoskeletal diseases (RMDs). We have organized our program around three groups of mentors represent a diverse set of UAB Departments and Programs at UAB: 1. Core Mentors: established, extramurally (primarily NIH) funded investigators with programs focused on RMDs committed to training the next generation of researchers; 2. Content Mentors: a) clinicians or researchers with expertise in RMDs but whose role is primarily supportive; or with research funding in areas complementary to, or synergistic with, RMDs; and 3. Mentors in Training: Early career faculty who will be developed into outstanding research mentors to further strengthen the RMD research environment. Trainees will be selected for their commitment to research and academic medicine, and the members of the UAB training faculty are fully committed to continuing to provide mentorship, support, and guidance to additional young investigators to help them develop into independent researchers who will advance our knowledge of RMDs. The UAB Rheumatology T32 program reflects a focused, relevant, multi-disciplinary translational research training program at UAB. Our training program has assembled an outstanding core of scientific mentors and is uniquely prepared and strongly committed to training of the next generation of rheumatic and musculoskeletal disease investigators and generate knowledge relevant to the mission and priorities of the NIAMS and the nation.

项目总结 UAB风湿病和肌肉骨骼疾病研究培训计划(主任：John D.Muntz，医学博士，博士；联席主任：Kenneth Saag，医学博士；副主任：Andre Ballesteros，博士)建立在在成人和儿童风湿学、免疫学、肌肉骨骼医学和我们的具备前期和后期翻译调查方面的专业知识。在过去5年的资助期内，我们建立了非常成功的项目，拥有一批优秀的核心导师，全面而灵活的培训计划，以及来自不同背景的基础和临床实习生的平衡组合。在这次重新提交的文件中申请，我们寻求继续专注于培养和发展高素质的博士前和致力于从事生物医学研究的博士后(博士、医学博士/博士或医学博士)实习生 NIAMS的使命。这个项目汇集了临床免疫科和风湿科和儿科风湿病、综合关节炎、肌肉骨骼、骨骼和自身免疫中心 (Cambac)等直接相关部门和方案提供了充满活力和有效的跨学科的培训环境。拟议的研究培训方案将继续加强协作科学的集成、交织结构，范围从基础分子发现到应用临床和转化性研究。它包含了一支老牌的、资金充足的致力于培训的教职员工。在风湿和肌肉骨骼疾病(RMD)中。我们围绕三个小组组织了我们的计划导师代表了UAB的不同部门和项目：1.核心导师：已建立的、外部资金(主要是NIH)资助的调查人员的项目侧重于RMD，致力于培训下一代研究人员；2.内容导师：a)具有RMD专业知识的临床医生或研究人员，但其作用主要是支持；或在与之互补或协同的领域提供研究资金， RMD；以及3.培训中的导师：将发展为杰出研究人员的早期职业教员导师们进一步加强了RMD的研究环境。学员将根据他们对以下方面的承诺进行挑选研究和学术医学，以及UAB培训学院的成员完全致力于继续为更多的年轻研究人员提供指导、支持和指导，帮助他们发展成为独立研究人员，他们将促进我们对RMD的了解。UAB风湿病T32计划反映了 UAB的重点、相关、多学科的翻译研究培训计划。我们的培训计划有汇聚了一批杰出的科学导师核心，做好了独特的准备，并坚定地致力于培训下一代风湿病和肌肉骨骼疾病调查人员并产生与 NIAMS和国家的使命和优先事项。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Working correlates of protection predict SchuS4-derived-vaccine candidates with improved efficacy against an intracellular bacterium, Francisella tularensis.

DOI：
10.1038/s41541-022-00506-9
发表时间：
2022-08-17
期刊：
NPJ vaccines
影响因子：
9.2
作者：
通讯作者：

Satisfaction with modes of telemedicine delivery during COVID-19: A randomized, single-blind, parallel group, noninferiority trial.

DOI：
10.1016/j.amjms.2022.06.021
发表时间：
2022-11
期刊：
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
影响因子：
3.1
作者：
Danila, Maria I.;Sun, Dongmei;Jackson, Lesley E.;Cutter, Gary;Jackson, Elizabeth A.;Ford, Eric W.;DeLaney, Erin;Mudano, Amy;Foster, Phillip J.;Rosas, Giovanna;Melnick, Joshua A.;Curtis, Jeffrey R.;Saag, Kenneth G.
通讯作者：
Saag, Kenneth G.

The Potential of Harnessing IL-2-Mediated Immunosuppression to Prevent Pathogenic B Cell Responses.