Exploring affect-motivated alcohol use as a value-based decision-making process

项目摘要/摘要 K99培训：拟议的K99/R00独立之路奖的目标是为Jonas博士提供 多拉接受过作为一名独立科学家开始职业生涯所需的培训。在获得认知科学博士学位后 心理学方面，多拉博士已经开始在酒精使用研究领域做出重要贡献 作为华盛顿大学心理学系的博士后研究员。这个 建议的K99训练期建立在Dora博士的博士背景和他目前在研究 酒精在自然环境中的使用。K99阶段将提供一段时间的强化训练 用实验、生态瞬时评估和计算方法研究酒精使用， 并将使多拉博士在以下过程中为酒精研究领域做出实质性贡献 他的事业。多拉博士将向拟议的导师(凯文·金博士)、当地合作者(威廉博士)学习 乔治、玛丽·拉里默)和外部合作者(马特·菲尔德博士、詹姆斯·墨菲博士、凯蒂·维特基维茨博士)，他们是 酒精使用领域的领先专家使用实验和生态有效的方法进行研究， 以及行为和主观数据的高级计算建模。此外，多拉博士将 参加课程、科学会议和研讨会，以满足其培训目标。伊利诺伊大学 华盛顿是一个世界级的研究机构，它提供了一个最佳的环境，必要的 资源，以及促进该项目成功完成的具有启发性的智力空间。 K99研究：与他的导师和合作者一起，多拉博士将在一个 模拟酒吧环境以及在人们的自然饮酒环境中进行研究，以检验这一想法 当大量饮酒的人同时饮酒和不饮酒时，可以观察到酒精的负强化和正强化。 酒精使用障碍(AUD)的症状会在酒精和无物质强化剂之间做出决定。 R00研究：多拉博士将使用一项任务翻译K99研究报告，该任务涉及以下假设选择 酒精和不含物质的增强剂进入了一项生态有效的测试，该假设为阳性和 消极情感以不同方式激发基于现实世界价值的饮酒决策(与规范情感相比 通过替代情绪调节策略)在日常生活中有/没有AUD症状的酗酒者。 意义：通过结合认知心理学和酒精使用研究的方法，本研究将 为酒精使用在积极和消极情绪面前强化这一观点提供了一种新的测试，以及 这样将推进澳大利亚国家航空航天局的战略目标，即确定有助于澳元发展的机制。通过研究 酒精使用作为一种基于价值的决策形式，该项目的见解将提出新的 在预防和治疗酒精使用障碍方面，有可能针对人们的情绪。

PROJECT SUMMARY/ABSTRACT K99 training: The goal of the proposed K99/R00 Pathway to Independence Award is to provide Dr. Jonas Dora with training needed to launch his career as an independent scientist. Following his PhD in cognitive psychology, Dr. Dora has already started to make important contributions to the field of alcohol use research as a postdoctoral research fellow in the Department of Psychology at the University of Washington. The proposed K99 training period builds on Dr. Dora’s PhD background and his current training in the study of alcohol use in natural environments. The K99 phase will provide a period of intensive training in the combined study of alcohol use with experimental, ecological momentary assessment, and computational approaches, and will position Dr. Dora to make substantial contributions to the field of alcohol research over the course of his career. Dr. Dora will learn from the proposed mentor (Dr. Kevin King), local collaborators (Drs. William George, Mary Larimer) and external collaborators (Drs. Matt Field, James Murphy, Katie Witkiewitz), who are leading experts in the field of alcohol use research using both experimental and ecologically valid approaches, as well as the advanced computational modeling of behavioral and subjective data. In addition, Dr. Dora will attend courses, scientific conferences, and workshops to meet his training objectives. The University of Washington is a world-class research institution that provides an optimal environment, the necessary resources, and a stimulating intellectual space to facilitate successful completion of this project. K99 research: Together with his mentor and collaborators, Dr. Dora will conduct controlled experiments in a simulated bar environment as well as studies in people’s natural drinking environment to test the idea that negative and positive reinforcement of alcohol can be observed when heavy drinkers with and without symptoms of alcohol use disorder (AUD) make decisions between alcohol and substance-free reinforcers. R00 research: Dr. Dora will translate the K99 research using a task involving hypothetical choices between alcohol and substance-free reinforcers into an ecologically valid test of the hypothesis that positive and negative affect differentially motivate real-world value-based decisions to consume alcohol (vs regulate affect via alternative emotion regulation strategies) in heavy drinkers with/without symptoms of AUD in everyday life. Significance: By combining methods from cognitive psychology and alcohol use research, this research will provide a novel test of the idea that alcohol use is reinforcing in the face of positive and negative emotions, and in that way will advance NIAAA’s strategic aim to identify mechanisms that contribute to AUD. By studying alcohol use as a form of value-based decision-making, the insights from this project will suggest new possibilities to target people’s emotions in the prevention and treatment of alcohol use disorder.