Kipiyecipakiciipe "coming home": Establishing clinical cultural neuroscience as a tool for understanding the role of traditional cultural engagement in mitigating substance misuse and disorder

Kipiyecipakiciipe“回家”：建立临床文化神经科学作为理解传统文化参与在减轻药物滥用和疾病中的作用的工具

• 批准号: 10740237
• 负责人: Evan James White
• 金额: $ 117.95万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10740237
• 关键词: Address; Adult; American Indians; Area; Awareness; Behavioral; Brain; Categories; Clinical; Cognitive; Collaborations; Communities; Disease; Disparity; Ethnic Origin; Evidence based intervention; Focus Groups; Geographic Distribution; Health; Health Disparities Research; Home; Human; Individual; Inequity; Knowledge; Link; Methods; Modeling; Neurosciences; Persons; Phase; Population; Prevalence; Prevention; Process; Race; Recovery; Religion; Research; Risk; Risk Factors; Role; Sampling; Science; Stimulus; Structure; Substance Use Disorder; Techniques; Tribes; Underserved Population; community based participatory research; community center; community engagement; design; experience; health equity; multimodal neuroimaging; neural; neurobehavioral; novel; racial minority population; resilience; resilience factor; social; social health determinants; substance misuse; substance use treatment; tool

PROJECT SUMMARY Inequities in substance use disorders (SUDs) among American Indian (AI) populations persist despite decades of awareness and research. Advancements in heretofore separate areas of SUD research have (1) underscored the importance of community based and culturally grounded research approaches in AI populations and (2) shown the promise of clinical neuroscience's role in addressing SUD. Merging these approaches through clinical-cultural neuroscience is a missing link in the field which holds large promise for advancing both SUD disparities research in AIs and underserved populations, and the neuroscientific understanding of SUD and recovery more broadly. This proposal integrates Community Based Participatory Research (CBPR) and clinical-neuroscience approaches to better delineate the brain processes that are important for SUD and that are impacted by traditional cultural engagement (TCE). The study aims to leverage the large promise of multimodal neuroimaging techniques as a method for probing TCE using objective markers of brain structure and function. Conceptualization of TCE will be done in collaboration with partners from the Shawnee Tribe (ST). This partnership is critical to the current project as culture comprises a broad category of human experiences common to a group of people and is often conflated with race, ethnicity, geographic distribution, and religion. This complexity has made it difficult to parse the influence of cultural factors and meaningfully incorporate TCE into disease and treatment models. Recently, advances in health disparities research among AI communities have conceptualized features of TCE under the framework of social determinants of health (SDH) to delineate specific risk and resilience factors for SUD. Furthermore, TCE has been supported as protective against and as treatment for SUD. The ST recognizes the impact of historical loss and degradation of cultural practices as a key factor in the prevalence of SUD and is committed to centering community engagement in developing evidence-based intervention and prevention efforts informed by and integrating traditional cultural knowledge and practices. Kipiyeecipsakiciipe “coming home” is a Shawnee word chosen by the ST partners to represent the effort of advancing the science of TCE in mitigating SUD disparities. A community advisory board of Shawnee adults will oversee the design, implementation, and interpretation of the study. A three phased approach will be used to provide a multi-level understanding of TCE as a protective SDH. Phase 1 will consist of focus groups aimed at refining a conceptualization of TCE specific to the ST to provide deep conceptual validity for behavioral probes and stimuli for neural probes of TCE. Phase 2 will examine neural probes of TCE and neurobehavioral and cognitive risk factors for SUD across individuals with varying degrees of TCE as defined by the CAB. Phase 3 will extend results to a sample of individual with SUD and healthy controls. This study will provide a framework for studying analogous cultural factor across other racial minority groups to advance health equity.

项目摘要 尽管数十年来，美国印第安人（AI）人群中物质使用障碍（SUD）的不平等仍然存在 的意识和研究。迄今为止，SUD研究的各个领域的进展有：（1） 强调了基于社区和文化基础的人工智能研究方法的重要性 （2）显示了临床神经科学在解决SUD中的作用的承诺。合并这些 通过临床文化神经科学的方法是该领域的一个缺失环节， 推进人工智能和服务不足人群的SUD差异研究，以及神经科学 更广泛地了解SUD和恢复。该提案将基于社区的 研究（CBPR）和临床神经科学方法，以更好地描绘大脑过程， 这对SUD很重要，并受到传统文化参与（TCE）的影响。该研究旨在利用 多模态神经成像技术作为一种客观探测TCE的方法的巨大前景 大脑结构和功能的标志。将与合作伙伴合作， 来自肖尼部落。这种伙伴关系对目前的项目至关重要，因为文化包括广泛的 一群人共同的人类经历的类别，经常与种族，民族， 地理分布和宗教。这种复杂性使得很难分析文化的影响， 我们的目标是将TCE纳入疾病和治疗模型。最近，健康方面的进展 人工智能社区之间的差异研究在以下框架下概念化了TCE的特征： 健康的社会决定因素（SDH）来描述SUD的具体风险和弹性因素。此外，TCE 已被支持作为预防和治疗SUD。 ST承认历史损失和文化习俗退化的影响是影响文化传统的一个关键因素。 SUD的患病率，并致力于集中社区参与发展循证医学 采取干预和预防措施，并将传统文化知识和做法纳入其中。 Kipiyeecipsakiciipe“回家”是ST合伙人选择的一个肖尼词，代表 促进TCE科学在减轻SUD差距。一个由肖尼族成年人组成的社区咨询委员会 将监督研究的设计、实施和解释。将采用分三个阶段的方法 提供对TCE作为保护性SDH的多层次理解。第一阶段将包括重点小组， 在细化特定于ST的TCE的概念化，为行为提供深层的概念有效性， TCE神经探针的探针和刺激物。第二阶段将检查TCE和神经行为的神经探针 和认知风险因素的SUD在个人与不同程度的TCE定义的CAB。 第3阶段将结果扩展至SUD个体和健康对照样本。这项研究将提供一个 研究其他少数种族群体类似文化因素的框架，以促进健康公平。