Prenatal Environment And Child Health (PEACH) in ECHO
ECHO 中的产前环境和儿童健康 (PEACH)
基本信息
- 批准号:10746727
- 负责人:
- 金额:$ 127.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAgeAssessment toolAttention deficit hyperactivity disorderAttenuatedBehaviorBehavioralBiologicalBloodCaliforniaChemicalsChildChild Behavior ChecklistChild HealthClinicalClinical assessmentsCommunitiesCommunity OutreachConceptionsDataDevelopmentDevelopmental Delay DisordersDisparityDoseEducational ActivitiesEnsureEnvironmentEnvironmental EpidemiologyEnvironmental ExposureEnvironmental PollutantsEpigenetic ProcessEthnic OriginExposure toFamilyFirst Pregnancy TrimesterFolic AcidFoodGeneticGrainGuidelinesHealthHealth PolicyHeavy MetalsHispanic PopulationsIntakeInterventionLinkMeasuresMediatingNeural Tube DefectsNeurodevelopmental DisorderNutritionalOutcomeParticipantPathway interactionsPersonsPlacentaPlasticizersPoliciesPopulation HeterogeneityPrevalencePreventive measureProblem behaviorProtocols documentationPsychosocial StressPublic HealthQuality of lifeRaceRecommendationResearchResourcesRiskShapesSiteSocial FunctioningSubgroupTranslationsUnderrepresented PopulationsUnited States National Institutes of HealthVisitWorkautism spectrum disorderautisticbehavioral outcomecohortcommunity engagementexecutive functionexperienceflexibilityfolic acid supplementationfortificationhigh riskimprovedin uteroinnovationlanguage outcomenovelnutritional epidemiologypeople of colorperceived discriminationpersonal care productspregnantprenatalprenatal exposureprogramsracial diversityrandomized trialrecruitreproductive epidemiologysocialsocioeconomicssuccesstrait
项目摘要
Prenatal Environment And Child Health (PEACH) in ECHO
Abstract
Few modifiable factors have been identified that improve neurodevelopmental (ND) outcomes. One such factor,
supplemental folic acid (SFA), taken before and during the first weeks post-conception, reduced risk for neural
tube defects (NTDs) by up to 70% in randomized trials, initiating mandatory food grain fortification and guidelines
for SFA intake for people who could or had become pregnant, with subsequent increases in blood folate
concentrations and reduced NTD prevalence. While generally regarded as a public health success, the impacts
have not been evenly distributed across sub-populations within the US, with Hispanic populations at higher risk
for NTDs, more likely to have suboptimal folate status, and less likely to take SFA. Further, the biologic
mechanisms behind this protection remain unclear. Prenatal SFA and adequate folate status has since been
associated with improved behavioral and language outcomes, higher executive functioning, and reduced risk for
attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and associated traits. High
folate/SFA has also been shown to attenuate increased risks associated with several contaminant exposures
that are more prevalent in groups that are under-represented in research and/or more likely to have sub-optimal
folate status and less likely to meet SFA intake recommendations. One example includes plasticizers in personal
care products that are more prevalent in Hispanic populations and are linked to increased ND risk which is
attenuated with prenatal SFA. Many gaps in understanding and implementation of SFA measures need to be
addressed to increase the public health impact of SFA interventions to their fullest potential: 1) How does the
timing of SFA initiation and its association with blood folate differ across subpopulations? 2) What other child
health outcomes are associated with prenatal SFA and blood folate? 3) How do these associations differ by the
timing and dose of SFA intake? 4) How do doses and timing of SFA and folate concentrations linked with
improved child outcomes differ across people with different genetic, environmental, and nutritional backgrounds?
5) Does periconceptional SFA/folate status modify associations between environmental contaminants, including
novel chemicals, and ND outcomes including behavioral problems and high autistic traits? 6) What biologic
pathways are modified in utero by periconceptional SFA and suboptimal folate status? 7) How do those biologic
pathways relate to known ND pathways? 8) How does the conceiving partner's preconception folate status relate
to placenta epigenetics and the child's outcomes? Our strong team with relevant expertise in reproductive,
environmental and nutritional epidemiology, interactions, epigenetics and ND assessment, plus ample
experience engaging community partners, will recruit 740 expecting families in Northern California representing
diverse racial, ethnic, socioeconomic, genetic and environmental backgrounds to enrich the ECHO cohort with
participants traditionally underrepresented in research to address these gaps and produce findings that will
substantially inform public health policies for more effective improvement of child developmental outcomes.
《ECHO》中的产前环境与儿童健康(桃子)
摘要
很少有可修饰的因素被确定可以改善神经发育(ND)结果。其中一个因素是,
补充叶酸(SFA),在怀孕前和怀孕后第一周服用,可降低神经风险
在随机试验中,管子缺陷(NTD)减少高达70%,启动强制性粮食强化和指南
对于可能或已经怀孕的人的SFA摄入量,随后血液叶酸增加
浓度和降低NTD患病率。虽然通常被认为是公共卫生的成功,但其影响
在美国境内的亚群中并不均匀分布,西班牙裔人口风险更高
对于NTDS,更有可能处于次优叶酸状态,而不太可能服用SFA。更进一步,生物
这种保护背后的机制仍不清楚。自那以后,产前SFA和充足的叶酸状况
与改善的行为和语言结果、更高的执行功能和降低
注意力缺陷/多动障碍(ADHD)、自闭症谱系障碍(ASD)及其相关特征。高
叶酸/SFA也被证明可以减轻与几种污染物暴露相关的增加的风险
在研究中代表性不足和/或更有可能处于次优状态的群体中更为普遍
叶酸状态,不太可能达到SFA的建议摄入量。一个例子是个人使用的增塑剂
护理产品在西班牙裔人群中更普遍,并与新城疫风险增加有关,
用产前SFA进行减重。在理解和执行SFA措施方面需要有许多差距
旨在最大限度地增加SFA干预措施对公共卫生的影响:1)如何
SFA开始的时间及其与血液叶酸的关系在不同的亚群中是不同的?2)其他什么孩子
健康结果与产前SFA和血液叶酸有关?3)这些关系有何不同
SFA摄入的时间和剂量?4)SFA和叶酸浓度的剂量和时间与
不同遗传、环境和营养背景的人改善的儿童结果是不同的?
5)概念周围的SFA/叶酸状态是否改变了环境污染物之间的联系,包括
新的化学物质和ND的结果,包括行为问题和高度自闭症特征?6)什么生物
妊娠期SFA和次优叶酸状态在子宫内改变途径?7)这些生物是如何
途径与已知的ND途径有关?8)受孕伴侣的先入性叶酸状况如何相关
胎盘表观遗传学和孩子的结局?我们拥有强大的团队,在生殖,
环境和营养流行病学、相互作用、表观遗传学和新城疫评估,以及充足的
体验社区合作伙伴,将在北加州招募740个预期家庭,代表
不同的种族、民族、社会经济、遗传和环境背景,以丰富回声队列
传统上,参与者在弥补这些差距并得出以下结论的研究中代表性不足
为公共卫生政策提供大量信息,以更有效地改善儿童发展成果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Rebecca Jean Schmidt其他文献
Rebecca Jean Schmidt的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Rebecca Jean Schmidt', 18)}}的其他基金
Bio-Specimen Assessment of Fire Effects (B-SAFE) Pregnancy Study
火灾影响生物样本评估 (B-SAFE) 妊娠研究
- 批准号:
9918374 - 财政年份:2019
- 资助金额:
$ 127.36万 - 项目类别:
Folic Acid Prevention Pathways for ASD in High Risk Families
高危家庭中自闭症谱系障碍 (ASD) 的叶酸预防途径
- 批准号:
9116188 - 财政年份:2015
- 资助金额:
$ 127.36万 - 项目类别:
Folic Acid Prevention Pathways for ASD in High Risk Families
高危家庭中自闭症谱系障碍 (ASD) 的叶酸预防途径
- 批准号:
8917743 - 财政年份:2015
- 资助金额:
$ 127.36万 - 项目类别:
Exploring Interactions between Folate and Environmental Risk Factors for Autism
探索叶酸与自闭症环境风险因素之间的相互作用
- 批准号:
8260107 - 财政年份:2012
- 资助金额:
$ 127.36万 - 项目类别:
Exploring Interactions between Folate and Environmental Risk Factors for Autism
探索叶酸与自闭症环境风险因素之间的相互作用
- 批准号:
8474757 - 财政年份:2012
- 资助金额:
$ 127.36万 - 项目类别:
Exploring Interactions between Folate and Environmental Risk Factors for Autism
探索叶酸与自闭症环境风险因素之间的相互作用
- 批准号:
8628125 - 财政年份:2012
- 资助金额:
$ 127.36万 - 项目类别:
相似海外基金
Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
- 批准号:
495182 - 财政年份:2023
- 资助金额:
$ 127.36万 - 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
- 批准号:
2601817 - 财政年份:2021
- 资助金额:
$ 127.36万 - 项目类别:
Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
- 批准号:
2029039 - 财政年份:2020
- 资助金额:
$ 127.36万 - 项目类别:
Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
- 批准号:
9888417 - 财政年份:2019
- 资助金额:
$ 127.36万 - 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
- 批准号:
17K11318 - 财政年份:2017
- 资助金额:
$ 127.36万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
10166936 - 财政年份:2017
- 资助金额:
$ 127.36万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9320090 - 财政年份:2017
- 资助金额:
$ 127.36万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9761593 - 财政年份:2017
- 资助金额:
$ 127.36万 - 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
- 批准号:
BB/M50306X/1 - 财政年份:2014
- 资助金额:
$ 127.36万 - 项目类别:
Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
- 批准号:
288272 - 财政年份:2013
- 资助金额:
$ 127.36万 - 项目类别:
Miscellaneous Programs