Exploring Interactions between Folate and Environmental Risk Factors for Autism

探索叶酸与自闭症环境风险因素之间的相互作用

基本信息

  • 批准号:
    8628125
  • 负责人:
  • 金额:
    $ 11.87万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-06-01 至 2016-02-29
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental disorder affecting 1:110 children in the United States. Evidence supports large heritable contributions to the etiology of ASD, though environmental factors are likely to modify both the development and the course of ASD. Prenatal nutrition and nutrient-environment interactions have been understudied in relation to autism etiology and risk. As the first researchers to examine maternal nutrition in association with autism risk, we found that mothers of children with autism were significantly less likely to report having taken prenatal vitamins around conception than mothers of typically developing (TD) children. Additionally, their estimated total folic acid intake was lower. Here it is proposed that maternal nutrient statu may contribute to the multifactorial etiology of autism by modifying susceptibility to other environmental agents. Animal studies show that folic acid supplementation can protect the fetus from environmental toxins through DNA methylation mechanisms. Thus, the overall purpose of this R21 is to examine interactions between nutrient status and environmental exposures in relation to ASD and to assess DNA methylation as a candidate mechanism for the modification of susceptibility. The focus is on two classes of environmental exposures that have been linked to increased ASD risk: traffic-related air pollution (TRP) and pesticides. Preliminary findings suggest attenuation of these associations from maternal periconceptional prenatal vitamin supplement intake. More specifically an investigation of whether two measures of folate status, maternally-reported folic acid intake and newborn bloodspot folate, act as effect modifiers for TRP and pesticides, while considering timing and dose or level of each exposure, and adjusting for confounders will be explored. Expectations here are that higher levels of folic acid before and during early pregnancy and neonate folate will reduce the risk of ASD associated with TRP and pesticide exposures in a dose-dependent manner. Further, an examination of global DNA methylation as a mechanism by which folate status may modify susceptibility to the environmental exposure effects will be tested. It is hypothesized that higher levels of folate will counter the neurodevelomentally relevant hypomethylation effects of these environmental exposures by providing abundant access to methyl-groups, (reflected in higher global DNA methylation levels in newborn bloodspots), and reducing their associated ASD risk. The proposed study will not only elucidate whether folate is able to reduce the neurodevelopmental consequences of harmful environmental exposures, but will also help reveal critical time periods and mechanisms behind potential protective effects. If the hypotheses are supported, this will be one of the first studies to identify complex relationships among modifiable risk factors for autism to be followed up in a prospective study, where we can assess timing, dose of exposures, and precise mechanisms more thoroughly. As such, it is likely to have a measurable impact on the scientific community, potentially on nutritional and environmental policies, and could potentially identify strategies for ASD prevention.
描述(由申请人提供):自闭症谱系障碍(ASD)是一种越来越普遍的神经发育障碍,影响美国1:10 0儿童。尽管环境因素可能会改变ASD的发展和病程,但证据支持遗传因素对ASD的病因有很大的贡献。产前营养和营养-环境相互作用与自闭症病因和风险的关系尚未得到充分研究。作为第一批研究母亲营养与自闭症风险之间关系的研究人员,我们发现自闭症儿童的母亲在怀孕前后服用产前维生素的可能性明显低于正常发育儿童的母亲。此外,他们估计的叶酸总摄入量也较低。本文提出,母亲的营养状况可能通过改变对其他环境因素的易感性而促成自闭症的多因素病因。动物研究表明,补充叶酸可以通过DNA甲基化机制保护胎儿免受环境毒素的侵害。因此,本R21的总体目的是研究与ASD相关的营养状况和环境暴露之间的相互作用,并评估DNA甲基化作为改变易感性的候选机制。重点是与ASD风险增加有关的两类环境暴露:交通相关的空气污染(TRP)和杀虫剂。初步研究结果表明,这些关联衰减从母体围孕期产前维生素补充摄入量。更具体地说,在考虑每次暴露的时间和剂量或水平,并根据混杂因素进行调整的同时,将探讨叶酸状态的两种测量方法,即母亲报告的叶酸摄入量和新生儿血斑叶酸,是否可以作为TRP和农药的效果调节剂。这里的预期是,在怀孕前和怀孕早期以及新生儿叶酸水平较高,将以剂量依赖的方式降低与TRP和农药接触相关的ASD风险。此外,还将测试全球DNA甲基化作为叶酸状态可能改变环境暴露效应易感性的机制。据推测,较高水平的叶酸会

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Rebecca Jean Schmidt其他文献

Rebecca Jean Schmidt的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Rebecca Jean Schmidt', 18)}}的其他基金

Prenatal Environment And Child Health (PEACH) in ECHO
ECHO 中的产前环境和儿童健康 (PEACH)
  • 批准号:
    10746727
  • 财政年份:
    2023
  • 资助金额:
    $ 11.87万
  • 项目类别:
Bio-Specimen Assessment of Fire Effects (B-SAFE) Pregnancy Study
火灾影响生物样本评估 (B-SAFE) 妊娠研究
  • 批准号:
    9918374
  • 财政年份:
    2019
  • 资助金额:
    $ 11.87万
  • 项目类别:
Folic Acid Prevention Pathways for ASD in High Risk Families
高危家庭中自闭症谱系障碍 (ASD) 的叶酸预防途径
  • 批准号:
    9116188
  • 财政年份:
    2015
  • 资助金额:
    $ 11.87万
  • 项目类别:
Folic Acid Prevention Pathways for ASD in High Risk Families
高危家庭中自闭症谱系障碍 (ASD) 的叶酸预防途径
  • 批准号:
    8917743
  • 财政年份:
    2015
  • 资助金额:
    $ 11.87万
  • 项目类别:
Exploring Interactions between Folate and Environmental Risk Factors for Autism
探索叶酸与自闭症环境风险因素之间的相互作用
  • 批准号:
    8260107
  • 财政年份:
    2012
  • 资助金额:
    $ 11.87万
  • 项目类别:
Exploring Interactions between Folate and Environmental Risk Factors for Autism
探索叶酸与自闭症环境风险因素之间的相互作用
  • 批准号:
    8474757
  • 财政年份:
    2012
  • 资助金额:
    $ 11.87万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 11.87万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 11.87万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 11.87万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 11.87万
  • 项目类别:
    Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 11.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 11.87万
  • 项目类别:
    Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 11.87万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 11.87万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 11.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 11.87万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了