Add Health Parent Study: A Biosocial Resource for the Study of Multigenerational Racial/Ethnic Disparities in Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD)

摘要 关于认知老化和阿尔茨海默病风险的代际维度存在重大知识差距， 海默氏病和阿尔茨海默氏病相关痴呆（AD/ADRD），以及这些过程如何不同 跨越种族和民族群体。拟议的添加健康父母研究（AHPS）第2阶段旨在- 弥补这些差距。AHPS是一项正在进行的关于影响健康的社会、行为和生物因素的研究。 目前年龄在58 - 90岁的成年人的全国样本中的老化和AD/ADRD的发展。样本部位 是国家青少年到成人健康纵向研究（添加健康）队列的父母，最初是在 在差异生存可能导致样本重复性偏倚之前，在中年早期（1994 - 95）添加健康中查看， 怨恨AHPS的第一阶段（2015 - 17）收集了父母随机子样本的纵向数据， 他们的配偶/伴侣（S/P，N = 3001），其中大多数（73%）是非西班牙裔（NH）白色人。的第2阶段 AHPS将收集所有可用的NH黑人和西班牙裔父母的社会，行为和健康数据（BHS sup- 补充，N = 2，505），以及所有AHPS 1期和BHS样本父母的认知评估和DNA数据 和他们目前的S/P（总N = 5，506）。通过增加NH黑人和西班牙裔父母，AHPS将足够稳定， 第一次有能力解决健康，社会和行为差异的测量， 不同种族/民族和社会经济阶层的AD/ADRD风险和保护因素。 来自AHPS第1和第2阶段的综合数据将与原始Add Health重新评估的丰富纵向数据相关联。 发起人创建和传播第一个具有全国代表性的多代生物社会资源 认知、基因组、行为和社会数据，用于研究认知老化中的种族/民族差异 AD/ADRD风险认知和基因组数据将在两代父母之间协调一致， 儿童AD/ADRD代际预测因素的创新分析;遗传过程在 AD/ADRD病因;代际和横向传播。项目的具体目标是： 1a.招募和采访额外的样本2,505 NH黑人和西班牙裔父母与AHPS调查。 1b.同意所有5，506名AHPS成员参与AD/ADRD评估和DNA数据收集。 2a.收集AHPS样本的DNA，进行SNP基因分型和DNA甲基化分析。 2b.开发代际基因组数据库，以促进对基因环境的理解 在AD/ADRD病因学中的相互作用。 3a.检查新的纵向和代际社会，健康和行为风险和预防因素 在不同种族/民族群体和社会阶层中的AD/ADRD。 3b.研究AHPS成员的创业经验和创业的社会经济后果， 与AD/ADRD病症或风险相关的经历。 4.记录、传播AHPS数据，并向全球科学界推广AHPS数据的使用。

Abstract Significant knowledge gaps exist regarding intergenerational dimensions of cognitive aging and risk for Alz- heimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD), and how these processes differ across race and ethnic groups. The proposed Add Health Parent Study (AHPS) Phase 2 is designed to ad- dress these gaps. AHPS is an ongoing study of social, behavioral, and biological factors influencing healthy aging and the development of AD/ADRD in a national sample of adults currently aged 58-90. Sample members are parents of the National Longitudinal Study of Adolescent to Adult Health (Add Health) cohort, initially inter- viewed in Add Health in early midlife (1994-95) before differential survival could contribute bias to sample rep- resentation. Phase 1 of AHPS (2015-17) collected longitudinal data on a random subsample of parents and their spouse/partners (S/P, N= 3001), the majority (73%) of whom were Non-Hispanic (NH) White. Phase 2 of AHPS will collect social, behavioral, and health data on all available NH Black and Hispanic parents (BHS sup- plement, N= 2,505), and cognitive assessments and DNA data on all AHPS Phase 1 and BHS sample parents and their current S/P (total N= 5,506). By adding NH Black and Hispanic parents, AHPS will be sufficiently sta- tistically powered to address, for the first time, measurement of health, social, and behavioral differences in AD/ADRD risk and protective factors across race/ethnic groups and socioeconomic strata. Combined data from AHPS Phases 1 and 2 will be linked with rich longitudinal data on original Add Health re- spondents to create and disseminate the first nationally representative multigenerational biosocial resource with cognitive, genomic, behavioral, and social data for the study of racial/ethnic disparities in cognitive aging and AD/ADRD risk. Cognition and genomic data will be harmonized across the two generations of parents and children for innovative analysis of intergenerational predictors of AD/ADRD; the role of genetic processes in AD/ADRD etiology; and intergenerational and lateral caregiving. Project specific aims are: 1a. Recruit and interview additional sample of 2,505 NH Black and Hispanic parents with the AHPS survey. 1b. Consent all 5,506 AHPS members for participation in AD/ADRD Assessment and DNA data collection. 2a. Collect DNA and conduct SNP genotyping and DNA methylation analysis on AHPS sample. 2b. Develop an intergenerational genomic database to advance an understanding of the gene-environment interplay in the etiology of AD/ADRD. 3a. Examine novel longitudinal and intergenerational social, health, and behavioral risk and preventive factors for AD/ADRD across racial/ethnic groups and social strata. 3b. Examine AHPS members’ caregiving experiences and the socioeconomic consequences of caregiving ex- periences related to AD/ADRD conditions or risks. 4. Document, disseminate, and promote use of AHPS data to the global scientific community.