Add Health Parent Study: A Biosocial Resource for the Study of Multigenerational Racial/Ethnic Disparities in Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD)

摘要 认知老化的代际维度和阿尔茨海默病的风险存在显著的知识差距。 海默病和阿尔茨海默病相关痴呆(AD/ADRD)，以及这些过程有何不同 不分种族和民族。拟议的Add Health Parent Study(AHPS)第二阶段旨在- 把这些缝隙补齐。AHPS是对影响健康的社会、行为和生物因素的持续研究 老龄化和AD/ADRD在目前58-90岁成年人的全国样本中的发展。示例成员 是全国青少年至成人健康纵向研究(ADD Health)队列的父母，最初是 在中年早期增加健康(1994-95)中，差异生存之前可能会对样本代表产生偏见 怨恨。AHPS第一阶段(2015-17年)收集了父母和 他们的配偶/伴侣(S/P，N=3000)，其中大多数(73%)是非西班牙裔(NH)白人。第2阶段： AHPS将收集所有NH Black和西班牙裔父母的社会、行为和健康数据(BHS sup- Plement，N=2,505)，以及所有AHPS阶段1和BHS样本父母的认知评估和DNA数据 和他们现在的S/P(总N=5,506)。通过增加NH Black和西班牙裔父母，AHPS将足够稳定- 组织能力首次解决健康、社交和行为差异的测量问题 各种族/族裔群体和社会经济阶层的AD/ADRD风险和保护因素。 来自AHPS阶段1和2的合并数据将与原始Add Health Re的丰富纵向数据相关联 海绵体创建和传播第一个具有全国代表性的多代生物社会资源 具有认知、基因组、行为和社会数据，用于研究认知老化的种族/民族差异 AD/ADRD风险。认知和基因组数据将在两代父母和 儿童对AD/ADRD代际预测因素的创新分析；遗传过程在 AD/ADRD病因学；代际和横向照顾。项目的具体目标是： 1A.通过AHPS调查招募和面试2,505名NH黑人和西班牙裔父母的额外样本。 1B.同意所有5,506名AHPS成员参加AD/ADRD评估和DNA数据收集。 2A。采集DNA，对AHPS样本进行SNP基因分型和DNA甲基化分析。 2B。开发代际基因组数据库以促进对基因环境的了解 AD/ADRD病因学的相互作用。 3A.检查新的纵向和代际社会、健康和行为风险及预防因素 针对不同种族/族裔群体和社会阶层的AD/ADRD。 3B.研究AHPS成员的照看经历和照看前的社会经济后果 与AD/ADRD条件或风险相关的事件。 4.向全球科学界记录、传播和促进使用AHPS数据。

Abstract Significant knowledge gaps exist regarding intergenerational dimensions of cognitive aging and risk for Alz- heimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD), and how these processes differ across race and ethnic groups. The proposed Add Health Parent Study (AHPS) Phase 2 is designed to ad- dress these gaps. AHPS is an ongoing study of social, behavioral, and biological factors influencing healthy aging and the development of AD/ADRD in a national sample of adults currently aged 58-90. Sample members are parents of the National Longitudinal Study of Adolescent to Adult Health (Add Health) cohort, initially inter- viewed in Add Health in early midlife (1994-95) before differential survival could contribute bias to sample rep- resentation. Phase 1 of AHPS (2015-17) collected longitudinal data on a random subsample of parents and their spouse/partners (S/P, N= 3001), the majority (73%) of whom were Non-Hispanic (NH) White. Phase 2 of AHPS will collect social, behavioral, and health data on all available NH Black and Hispanic parents (BHS sup- plement, N= 2,505), and cognitive assessments and DNA data on all AHPS Phase 1 and BHS sample parents and their current S/P (total N= 5,506). By adding NH Black and Hispanic parents, AHPS will be sufficiently sta- tistically powered to address, for the first time, measurement of health, social, and behavioral differences in AD/ADRD risk and protective factors across race/ethnic groups and socioeconomic strata. Combined data from AHPS Phases 1 and 2 will be linked with rich longitudinal data on original Add Health re- spondents to create and disseminate the first nationally representative multigenerational biosocial resource with cognitive, genomic, behavioral, and social data for the study of racial/ethnic disparities in cognitive aging and AD/ADRD risk. Cognition and genomic data will be harmonized across the two generations of parents and children for innovative analysis of intergenerational predictors of AD/ADRD; the role of genetic processes in AD/ADRD etiology; and intergenerational and lateral caregiving. Project specific aims are: 1a. Recruit and interview additional sample of 2,505 NH Black and Hispanic parents with the AHPS survey. 1b. Consent all 5,506 AHPS members for participation in AD/ADRD Assessment and DNA data collection. 2a. Collect DNA and conduct SNP genotyping and DNA methylation analysis on AHPS sample. 2b. Develop an intergenerational genomic database to advance an understanding of the gene-environment interplay in the etiology of AD/ADRD. 3a. Examine novel longitudinal and intergenerational social, health, and behavioral risk and preventive factors for AD/ADRD across racial/ethnic groups and social strata. 3b. Examine AHPS members’ caregiving experiences and the socioeconomic consequences of caregiving ex- periences related to AD/ADRD conditions or risks. 4. Document, disseminate, and promote use of AHPS data to the global scientific community.