Understanding associations between timing of physical activity and health outcomes in young adults

了解年轻人身体活动时间与健康结果之间的关联

基本信息

批准号：
10747742
负责人：
Caitlin Bailey
金额：
$ 4.49万
依托单位：
GEORGE WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10747742
关键词：
Abdomen Accelerometer Address Adult Age Behavior Behavioral Behavioral Sciences Biological Rhythm Blood Pressure Body Weight Body Weight decreased Cardiometabolic Disease Categories Cholesterol Chronic Disease Circadian desynchrony Climacteric Control Groups Coupled Cross-Sectional Studies Data Development Disease Management Elderly Etiology Exercise Female Future Glycosylated hemoglobin A Goals Guidelines Health Intervention Jet Lag Syndrome Knowledge Longitudinal Studies Measures Mediating Metabolic syndrome Methods National Heart, Lung, and Blood Institute National Institute of Diabetes and Digestive and Kidney Diseases Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Overweight Participant Pattern Physical activity Physical assessment Physiological Prevalence Prevention strategy Public Health Randomized Randomized, Controlled Trials Reporting Research Research Priority Risk Risk Factors Role Sampling Scientist Site Sleep Stress Techniques Technology Testing Time United States National Institutes of Health Weight Weight maintenance regimen actigraphy age group behavior change cardiometabolic risk cardiometabolism cardiovascular risk factor career circadian cohort design disorder risk exercise intervention experience fasting glucose fitness follow-up high body mass index improved innovation interest men&apos s group middle age moderate-to-vigorous physical activity obesity management obesity prevention physical conditioning poor sleep prevent prospective randomized controlled design sex social theories treatment group young adult

项目摘要

ABSTRACT To prevent and manage chronic disease, national guidelines call for a minimum of 150 minutes of moderate-to- vigorous physical activity per week; yet little is known about what time of day is best for performing this activity. The timing of physical activity may be particularly important for young adults who are vulnerable to social jetlag (i.e., discrepancy between biological rhythms and sleep/wake behaviors), placing them at increased risk of developing chronic diseases. Research in adult samples indicates that morning activity may be beneficial for weight management and/or cardiometabolic risk factors; however, there is a lack of longitudinal studies to support these findings. Furthermore, little is known about the timing of physical activity and health outcomes among young adults who are physiologically different from their adult counterparts and at increased risk of social jetlag/circadian misalignment. We aim to examine the cross-sectional and longitudinal relationships of physical activity timing with weight and cardiometabolic risk factors in a cohort of young adults at risk for cardiometabolic disease. Specifically, we will use data from the Healthy Body Healthy U (HBHU) trial [NIH/NIDDK R01 DK100916], a completed two-site weight management randomized controlled trial for young adults, ages 18-35. We will use objective physical activity data measured via the ActiGraph accelerometer at four time-points (Baseline, Month 6, Month 12, Month 18) to identify activity time categories (i.e., morning, afternoon, evening, night-time) and examine how differences at baseline, and changes over time, in activity during each time category relate to health outcomes (i.e., weight, cardiometabolic risk factors). We hypothesize that: 1) morning activity will be associated with lower weight at baseline and greater weight loss over the follow-up, 2) morning activity will be associated with fewer cardiometabolic risk factors at baseline and reductions in these risk factors over the follow-up, 3) the proposed associations between morning activity and improved weight/cardiometabolic risk factors will be mediated by greater weekly volumes of moderate-to- vigorous physical activity, and 4) age, sex, and intervention status will moderate the relationships. The proposed study is innovative in (a) its use of longitudinal data over 18 months to test associations between timing of activity and health outcomes, (b) its use of an at-risk young adult sample and (c) its use of a randomized controlled design to test the impact of a technology-based health messaging intervention on the associations of interest. The long-term goal of our research is to inform the design of timing-focused, theory- based behavior change interventions for at-risk young adults.

抽象的为了预防和管理慢性病，国家准则要求至少150分钟每周剧烈的体育锻炼；然而，对于一天中的哪些时间最适合执行这项活动。体育锻炼的时机对于容易受到社交喷气lag攻击的年轻人尤其重要（即生物节奏与睡眠/唤醒行为之间的差异），使它们处于增加的风险发展慢性疾病。成人样本的研究表明，早晨的活动可能对体重管理和/或心脏代谢风险因素；但是，缺乏纵向研究支持这些发现。此外，关于体育锻炼和健康成果的时机知之甚少在生理学上与成年人不同的年轻人中社交喷气lag/昼夜节律错位。我们旨在检查体重和体重和心脏代谢危险因素的身体活动计时，其中一群有风险的年轻人心脏代谢疾病。具体而言，我们将使用健康身体健康U（HBHU）试验的数据 [NIH/NIDDK R01 DK100916]，一个完整的Young的两次重量管理随机对照试验成年人，18-35岁。我们将使用通过Actigraph加速度计测量的客观体育活动数据四个时间点（基线，第6个月，第12个月，第18个月）确定活动时间类别（即早晨，下午，晚上，夜间）并检查基线的差异和随着时间的变化如何变化在每个时间内，类别都与健康结果有关（即体重，心脏代谢风险因素）。我们假设那是：1）早晨的活动将与基线时的体重降低相关，而在随访，2）早晨的活动将与基线和基线时的心脏代谢危险因素更少有关在随访中减少这些危险因素，3）早晨活动与改善的体重/心脏代谢危险因素将由每周大量中等到中等的体积介导剧烈的体育锻炼，4）年龄，性别和干预状况将减轻关系。这拟议的研究具有（a）在18个月内使用纵向数据的创新性来测试关联活动和健康成果的时机，（b）使用高危年轻的成人样本和（c）随机控制设计，以测试基于技术的健康消息干预对感兴趣的协会。我们研究的长期目标是告知以时计时，理论的设计 - 高危年轻人的基于行为改变干预措施。