Reducing cervical cancer screening disparities in Somali immigrant women through a primary care based HPV self-sampling intervention

通过基于初级保健的 HPV 自我采样干预措施减少索马里移民妇女的宫颈癌筛查差异

• 批准号: 10746677
• 负责人: Rebekah J. Pratt
• 金额: $ 4.1万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746677
• 关键词: Address; Appointment; Awareness; COVID-19 pandemic; Cervical; Cervical Cancer Screening; Clinic; Consolidated Framework for Implementation Research; Data; Development; Disparity; Electronic Health Record; Female; Focus Groups; Health; Health Personnel; Home; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Hybrids; Immigrant; Intervention; Interview; Lesion; Male Circumcision; Malignant neoplasm of cervix uteri; Methods; Minority Groups; Modality; Neighborhoods; Pap smear; Patients; Population; Positioning Attribute; Primary Care; Process; Provider; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Recovery; Religious Belief; Research; Sampling; Screening for cancer; Self Efficacy; Services; System; Testing; Time; Travel; Woman; Work; acceptability and feasibility; budget impact; cost; deprivation; disparity reduction; effectiveness evaluation; effectiveness/implementation design; health care disparity; implementation science; implementation strategy; indexing; intervention refinement; novel strategies; outcome disparities; pandemic disease; parent grant; patient oriented; patient population; patient subsets; post implementation; premalignant; primary care clinic; primary care setting; screening; screening disparities; screening participation; screening services; social cognitive theory; standard of care; uptake

SUMMARY/ABSTRACT Somali women living in the U.S. have lower cervical cancer screening rates than the U.S. general female population. This disparity is due to a range of factors, including limited awareness of HPV and cervical cancer, cultural and religious beliefs, mistrust of health care providers, concerns around modesty and circumcision, and low provider self-efficacy to perform Pap tests on circumcised women. HPV self-sampling is an emerging cervical cancer screening modality that may address common screening barriers among Somali women, particularly those related to modesty and circumcision. HPV self-sampling is accurate for detecting pre- cancerous cervical lesions and effective in reaching underscreened women. In addition, our pilot work has demonstrated the feasibility and acceptability of HPV self-sampling in Somali women. While research has focused primarily on home-based HPV self-sampling, there is an untapped opportunity to offer HPV self- sampling in the primary care setting. Offering HPV self-sampling in primary care could effectively increase cervical cancer screening rates in Somali women by positioning providers to address screening barriers, enabling clinics to opportunistically fit in HPV self-sampling with other appointments, and providing an alternative modality for circumcised women. We propose a Hybrid Type 2 effectiveness-implementation design to assess the effectiveness and implementation of a patient-centered, culturally-tailored HPV self-sampling intervention for Somali women. Guided by the Consolidated Framework for Implementation Science and Social Cognitive Theory, we will conduct focus groups with Somali patients and interviews with providers to identify patient-, provider-, clinic-, and systems-level factors to inform refinement of intervention materials and development of implementation strategies (Aim 1). After tailoring the intervention, we will then implement HPV self-sampling in 2 primary care clinics, and evaluate changes in Somali women’s cervical cancer screening rates one-year pre and one-year post implementation (Aim 2). Changes will be compared with Somali women attending 27 control clinics followed over the same time period, using difference-in-difference methods. Finally, using RE-AIM, we will conduct a post-implementation mixed methods analysis of the processes and strategies needed to successfully implement HPV self-sampling in primary care for Somali patients (Aim 3), including interviews with providers and Somali women. Our hypothesis is that implementing HPV self-sampling in primary care will lead to increased uptake of cervical cancer screening in Somali women and that an implementation science based analysis of the processes needed to successfully implement the intervention will lead to sustainable, novel strategies to support the sustained integration of HPV self-sampling into primary care.

总结/摘要 生活在美国的索马里妇女的宫颈癌筛查率低于美国普通女性 人口这种差异是由一系列因素造成的，包括对HPV和宫颈癌的认识有限， 文化和宗教信仰，对卫生保健提供者的不信任，对谦虚和割礼的担忧， 对接受过包皮环切术的妇女进行巴氏试验的自我效能较低。HPV自我采样是一种新兴的 宫颈癌筛查模式，可解决索马里妇女常见的筛查障碍， 特别是那些与谦虚和割礼有关的问题。HPV自我采样是准确的检测前 癌症宫颈病变，并有效地接触到筛查不足的妇女。此外，我们的试点工作， 证明了索马里妇女HPV自我采样的可行性和可接受性。虽然研究 主要集中在家庭为基础的HPV自我采样，有一个未开发的机会，提供HPV自我， 在初级保健环境中抽样。在初级保健中提供HPV自我采样可以有效地增加 通过定位提供者解决筛查障碍，提高索马里妇女的宫颈癌筛查率， 使诊所能够有机会适应HPV自我采样与其他预约，并提供一个 为接受割礼的妇女提供替代方式。我们提出了一种混合型2有效性实现设计 评估以患者为中心、文化定制的HPV自我采样的有效性和实施情况 为索马里妇女进行干预。在《科学和社会发展综合执行框架》的指导下， 认知理论，我们将与索马里患者进行焦点小组讨论，并与提供者进行访谈，以确定 患者、提供者、诊所和系统层面的因素，为干预材料的完善提供信息， 制定实施战略（目标1）。在定制干预措施后，我们将实施HPV 在2个初级保健诊所进行自我抽样，并评价索马里妇女宫颈癌筛查的变化 实施前一年和实施后一年的比率（目标2）。变化将与索马里妇女进行比较 参加27个对照诊所在同一时间段内，使用差异中差异的方法。最后， 使用RE-AIM，我们将对过程和战略进行实施后的混合方法分析 需要在索马里患者的初级保健中成功实施HPV自我采样（目标3），包括 与供应商和索马里妇女的访谈。我们的假设是，实施HPV自我采样， 初级保健将导致索马里妇女接受宫颈癌筛查的人数增加， 对成功实施干预措施所需的过程进行基于实施科学的分析， 导致可持续的，新的战略，以支持持续整合HPV自我采样到小学 在乎