Skin-like wearable biosensors for multimodal mental health biomarker monitoring

用于多模式心理健康生物标志物监测的类肤可穿戴生物传感器

基本信息

  • 批准号:
    10750863
  • 负责人:
  • 金额:
    $ 7.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-07-01 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Mental disorders affect one in four people worldwide (~2 billion people), with the cost of mental health conditions projected to reach $6 trillion by 2030. Unfortunately, mental disorders are difficult to diagnose, monitor, and treat. Repeated triggering of daily stress can also lead to chronic stress, associated with higher risks of mental disorders, weakening immuneresponse, and cardiovascular diseases. Despite the mental health crisis, available resources and access to care scarcely begin to meet the need. Moreover, there are no objective tests or scalable technologies for detecting chronic stress. To advance precision mental healthcare, we need continuous, predictive, and quantitative measurements of mental states for stress, anxiety, and depression. Wearable devices can transform mental health care due to their ability to monitor previously inaccessible biodata. However, there are limited wearable devices designed for mental health monitoring. In the proposed research, I will tackle the mentioned problems in mental health monitoring by developing platform technologies based on skin-like wearable biosensors. The focus of the proposed study is to create a soft and wearable biosensor that can measure multiple mental health biomarkers wirelessly in real-time, providing quantifiable metrics to assist diagnosis, treatment, monitoring, and prevention of mental disorders. Two new technologies will be developed: a soft and wireless patch to measure mental health-related physical biomarkers on the skin and a new organic biosensor platform to monitor chemical biomarkers in sweat. First, I will design a soft and wireless sensor patch to monitor skin conductance changes in response to acute stressors and circadian rhythm. The designed skin conductance sensor patch, composed of intrinsically stretchable and soft materials, will provide seamless integration with skin and accurate measurement with high signal-to-noise ratios. Second, I will fabricate a soft chemical biosensor to monitor the stress hormone in sweat using organic field-effect transistors. A highly sensitive and selective aptamer chemical biosensor will be utilized in a skin-like organic material system. Both alone and combined, the skin-like wearable systems will allow continuous quantitative monitoring of mental health biomarkers, assisting in the prevention and treatment of mental disorders. Professor Zhenan Bao, Professor Leanne Williams, and Stanford University provide the tools and expertise needed to accomplish the proposed research. Working with Professor Bao, a leading scientist in the field of intrinsically stretchable materials, I will acquire scientific skills in the design, fabrication, and characterization techniques of organic materials and bioelectronics. In addition, I will gain experience working with human subjects during this postdoctoral training. For this reason, I am working with Professor Williams, my co-mentor, who is a leading professor in psychiatry and behavioral sciences. Moreover, I will obtain training in psychiatry and electrical engineering by taking classes at Stanford. This environment provides the expertise needed to accomplish the proposed research and provide me with the appropriate training to pursue a career in academic research.
项目摘要 精神障碍影响全球四分之一的人(约20亿人),心理健康状况的成本 预计到2030年将达到6万亿美元。不幸的是,精神疾病很难诊断、监测和治疗。 反复引发日常压力也会导致慢性压力,与精神疾病的风险较高有关。 疾病,免疫反应减弱,以及心血管疾病。尽管存在心理健康危机, 资源和获得护理的机会开始难以满足需要。此外,没有客观的测试或可扩展的 检测慢性压力的技术。为了推进精准的精神卫生保健,我们需要持续的, 压力、焦虑和抑郁的心理状态的预测和定量测量。可穿戴 由于能够监测以前无法获得的生物数据,这些设备可以改变精神卫生保健。然而,在这方面, 设计用于心理健康监测的可穿戴设备有限。在研究中,我将解决 通过开发基于类皮肤的平台技术, 可穿戴生物传感器拟议研究的重点是创建一个软的和可穿戴的生物传感器, 实时无线测量多种心理健康生物标志物,提供可量化的指标, 精神疾病的诊断、治疗、监测和预防。将开发两项新技术: 一种柔软的无线贴片,用于测量皮肤上与心理健康相关的身体生物标志物, 生物传感器平台来监测汗液中的化学生物标志物。首先,我将设计一个柔软和无线传感器贴片 监测皮肤电导变化,以应对急性应激源和昼夜节律。设计的皮肤 电导传感器贴片,由固有的可拉伸和柔软的材料组成,将提供无缝的 与皮肤的集成以及具有高信噪比的精确测量。第二,我会编造一个软 化学生物传感器使用有机场效应晶体管监测汗液中的应激激素。一个高度 敏感性和选择性的适体化学生物传感器将用于类皮肤有机材料系统。两 单独和组合,皮肤般的可穿戴系统将允许连续定量监测精神 健康生物标志物,协助预防和治疗精神障碍。鲍哲南教授, Leanne威廉姆斯教授和斯坦福大学提供了完成 提议的研究。与鲍教授合作,鲍教授是内在可拉伸领域的领先科学家, 材料,我将获得科学技能的设计,制造和表征技术的有机 材料和生物电子学。此外,我将在此期间获得与人类受试者合作的经验。 博士后培训。出于这个原因,我与威廉姆斯教授,我的共同导师,谁是一个领先的 精神病学和行为科学教授此外,我将获得精神病学和电气方面的培训, 通过在斯坦福大学上课来学习工程学。此环境提供了完成 建议的研究,并为我提供适当的培训,以追求学术研究的职业生涯。

项目成果

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