CSHL 2023 Mechanisms of Metabolic Signaling Conference

冷泉港实验室会议 代谢信号传导机制 2023年5月16日至20日 项目摘要 这项建议寻求支持的会议"机制的代谢信号"， 于2023年5月16日至20日在冷泉港实验室举行。会议将聚集各国领导人 在外地，与初级教师，博士后研究员和研究生一起，讨论 我们对代谢调节及其在正常生理学中的作用的理解的最新进展， 以及从肥胖到癌症的各种疾病状态。 代谢过程是生命所必需的，并且在生物体之间非常相似 从细胞到细胞。在哺乳动物中，特定的细胞类型使用高度专门化的代谢途径， 进行细胞特异性功能的方法。此外，某些细胞类型的专门功能 用于通过调节多细胞生物的代谢水平来维持多细胞生物的代谢稳态。 激素和代谢物的信使。肥胖等代谢性疾病 当这些过程失败时就会导致糖尿病。与此同时，癌症越来越多地 被认为是恶性细胞通过改变其燃料代谢而增殖的状态， 忽略代谢信号 会议将涵盖广泛的主题，从代谢串扰与基因组 表观基因组与器官间串扰和养分利用此外，一届会议是 致力于该领域的新兴技术。每届会议将由一位领导人主持。 领域的科学家。一组杰出的特邀演讲者将作口头介绍 以及从提交的摘要中选出的发言者。选定的演讲者将包括研究生 学生，博士后研究员和初级教师，旨在最大限度地包容年轻人 investigators.特别重要的是两个海报会议，许多与会者可以 在有利于非正式讨论的气氛中介绍他们的工作。会议将由 中等规模，我们预计约有250人参加，其中绝大多数将是 展示海报或演讲。会议主席和发言人将被要求亲自出席， 确保聚集在冷泉港的与会者达到临界质量;但是，我们将促进 在亲自出席的基础上增加额外的虚拟观众。这将是重要的， 因为在大流行之后，旅行问题可能会持续一段时间，而且， 展望未来，虚拟出席会议将有助于减少科学的影响， 气候变化会议，并使世界各地的实验室能够更公平地参与， 世界

Cold Spring Harbor Laboratory Conference on Mechanisms of Metabolic Signaling May 16 – 20, 2023 Project Summary This proposal seeks support for the meeting on “Mechanisms of Metabolic Signaling” to be held at Cold Spring Harbor Laboratory in May 16 - 20, 2023. The meeting will assemble leaders in the field, together with junior faculty, postdoctoral fellows and graduate students, to discuss the latest advances in our understanding of metabolic regulation and its role in normal physiology as well as a variety of disease states ranging from obesity to cancer. Metabolic processes are required for life, and are remarkably similar from organism to organism and from cell to cell. In mammals, specific cell types use metabolic pathways in highly specialized ways to conduct their cell-specific functions. Further, the specialized function of some cell types serves to maintain metabolic homeostasis of the, multicellular organism by regulating levels of hormone and metabolite messengers in the bloodstream. Metabolic diseases such as obesity and diabetes result when those processes fail. At the same time, cancer is increasingly recognized as a state whereby the malignant cell proliferates by altering its fuel metabolism and ignoring metabolic signals. The meeting will cover a broad spectrum of topics ranging from Metabolic Crosstalk with Genome and Epigenome to Interorgan Crosstalk and Nutrient Utilization. In addition, one session is dedicated to Emerging Technologies in the field. Each session will be chaired by a leading scientist in the field. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. The meeting will be of moderate size, and we expect about 250 people to attend, the vast majority of whom will be presenting a poster or talk. Session chairs and presenters will be required to attend in-person to ensure a critical mass of attendees gathering at Cold Spring Harbor; however, we will facilitate an additional virtual audience layered on top of the in person attendance. This will be important both because travel concerns are likely to persist for some time after the pandemic, and because, looking to the future, virtual attendance at meetings will help to reduce the effects of scientific conferences on climate change and enable more equitable participation from labs around the world.