Harvard School of Dental Medicine Collaborative Clinical Practice-based REsearch Program for DENTal Schools (H-CREDENT)

哈佛大学牙科医学院牙科学院基于临床实践的合作研究计划 (H-CREDENT)

• 批准号: 10754738
• 负责人: WILLIAM V GIANNOBILE
• 金额: $ 85.91万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-13 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10754738
• 关键词: Active Learning; Address; Age; Aptitude; Artificial Intelligence; Basic Science; Clinical; Clinical Research; Collaborations; Communities; Complement; Dedications; Dental; Dental Care; Dental Education; Dental Faculty; Dental General Practice; Dental Schools; Dental Students; Dentistry; Development; Enrollment; Face; Faculty; Fostering; Genetic; Genomics; Goals; Health Alliance; Health Personnel; Health Sciences; Healthcare; Individual; Institution; Investigation; Learning; Machine Learning; Massachusetts; Measures; Medicine; Mentors; Mentorship; Mission; National Institute of Dental and Craniofacial Research; Neighborhood Health Center; New England; Oral; Oral health; Outcome; Pain; Pain management; Participant; Patients; Pharmacy facility; Population; Post-Procedural Pain; Postdoctoral Fellow; Postoperative Pain; Practice based research; Predictive Factor; Private Practice; Problem Solving; Program Development; Provider; Research; Research Design; Research Methodology; Research Personnel; Risk; Risk Factors; Salivary; Scientific Inquiry; Site; Stratification; Students; Training; Training Programs; Translational Research; Universities; Work; care burden; career; catalyst; clinical care; clinical investigation; clinical practice; college; craniofacial; demographics; doctoral student; experience; follow-up; health care delivery; high risk; innovation; inter-institutional; longitudinal, prospective study; machine learning method; member; multidisciplinary; next generation; pain-related disability; patient stratification; peer; practice-based research network; programs; prospective; psychosocial; public health research; recruit; research faculty; risk stratification; skill acquisition

Project Summary/Abstract The Harvard School of Dental Medicine Collaborative Clinical Practice-based REsearch Program for DENTal Schools (H-CREDENT) will embark on an innovative, multidisciplinary practice-based research program to engage dental students and residents with research and clinical-based faculty to address the challenge of pain management in dentistry. H-CREDENT is a partnership amongst HSDM, University of New England, Massachusetts College of Pharmacy & Health Sciences, Meharry University, Charles River Community Health Center, and Cambridge Health Alliance. The program provides didactic and hands-on clinical research opportunities to deliver an experiential-learning/training for pre-/postdoctoral students and clinical/research faculty at these sites. Leveraging the unique diversity in the provider/patient communities brought together by this collaboration, H-CREDENT strives to prepare the next-generation oral healthcare providers through the conduct of practice-based clinical research to enhance precision oral healthcare delivery. H-CREDENT will work towards this goal by accomplishing 2 aims: Aim 1: Establishment of clinical research skills development program that will train next-generation clinical scholars in practice-based research networks (PBRNs). Skills development will be advanced via a) coursework in clinical research study design and PBR, complemented by b) unique pod-based mentorship program for experiential learning. Courses will be developed by HSDM investigators in partnership with Harvard Catalyst, national PBRN, and a premier network of private practice clinicians with extensive experience in clinical research. The courses will be taken by H- CREDENT trainees from all collaborating sites, and each mentoring pod will comprise research-/clinical-focused faculty and pre-/ postdoctoral trainees from all institutions to promote strong mentorship relationships, both vertically (e.g., student/faculty) and laterally (e.g., peer-peer) across institutions. Aim 2: A PBRN investigation to engage dental student and faculty providers to determine risk factors for developing pain following invasive dental procedures and stratify patients based on demographic, psychosocial, and genetic factors. We will a) determine risk factors predicting pain after dental procedures and b) how well the dental providers can predict the patients’ pain experience and if biases influence this prediction, and c) identify patients as low-/ high-risk for developing post-procedural pain through patient stratification by applying artificial intelligence/ machine learning methods. This prospective longitudinal study will take place at all sites, where pre-/postdoctoral students will recruit/enroll, perform dental procedures, and follow up with patients, under the guidance of their clinical mentor. Differential experiences by H-CREDENT trainees across institutions will be shared via mentoring pods to integrate and reinforce learnings from the classroom and direct participation in clinical research. Through these activities, H-CREDENT will foster a culture of scientific inquiry to prepare dental providers with aptitude for conducting effective practice-based clinical research.

项目总结/摘要 哈佛口腔医学院临床实践协作研究项目 DENTal学校（H-CREDENT）将开展一项创新的、基于实践的多学科研究计划 让牙科学生和居民与研究和临床教师一起应对以下挑战： 牙科疼痛管理H-CREDENT是HSDM，新英格兰大学， 马萨诸塞州药学与健康科学学院，梅哈里大学，查尔斯河社区卫生 中心和剑桥健康联盟。该计划提供教学和动手临床研究 为博士前/博士后学生和临床/研究提供体验式学习/培训的机会 在这些网站的教师。利用提供者/患者社区的独特多样性， 通过此次合作，H-CREDENT致力于为下一代口腔保健提供商做好准备， 开展以实践为基础的临床研究，以提高精确的口腔保健服务。 H-CREDENT将通过实现两个目标来实现这一目标：目标1：建立临床 研究技能发展计划，将培养下一代临床学者在实践为基础的研究 网络（PBRN）技能发展将通过a）临床研究设计课程和 PBR，辅以B）独特的基于播客的体验式学习导师计划。课程将 由HSDM研究人员与哈佛催化剂公司、国家PBRN和一个一流的网络合作开发 拥有丰富临床研究经验的私人执业临床医生。这些课程将由H- 来自所有合作研究中心的CREDENT受训人员，每个指导小组将包括以研究/临床为重点的 来自所有机构的教师和博士前/博士后学员，以促进牢固的导师关系， 垂直地（例如，学生/教员）和横向（例如，peer-peer）跨机构。目标2：PBRN研究 让牙科学生和教职员工参与进来，以确定侵入性手术后发生疼痛的风险因素， 牙科手术，并根据人口统计学、心理社会学和遗传因素对患者进行分层。我们将（a） 确定预测牙科手术后疼痛的风险因素，以及B）牙科提供者能够预测 患者的疼痛经历以及偏差是否影响该预测，以及c）将患者识别为低/高风险， 通过应用人工智能/机器学习，通过患者分层开发术后疼痛 方法.这项前瞻性纵向研究将在所有研究中心进行，其中博士前/博士后学生将 招募/登记，进行牙科手术，并在临床导师的指导下随访患者。 H-CREDENT学员在各机构的不同经验将通过辅导舱分享， 整合和加强课堂学习，并直接参与临床研究。通过这些 活动，H-CREDENT将促进科学探究的文化，使牙科医生具备以下能力： 开展有效的临床实践研究。