Adaptive Testing of Cognitive Function based on multi-dimensionalItem Response Theory

基于多维项目反应理论的认知功能自适应测试

• 批准号: 10900990
• 负责人: ROBERT D GIBBONS
• 金额: $ 90.33万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10900990
• 关键词: Administrator; Adopted; Adult; Age; Age Years; Aging; Alzheimer' s Disease; American; Applied Research; Assessment tool; Basic Science; Calibration; Clinic; Clinical; Cognition; Cognitive; Computers; Consumption; Data; Development; Dimensions; Discrimination; Early Diagnosis; Early Intervention; Elderly; Episodic memory; Evaluation; Funding; Health; Healthcare; Human Resources; Immune; Impaired cognition; Impairment; Individual; Internet; Language; Learning; Life Cycle Stages; Link; Longevity; Longitudinal Studies; Masks; Measurement; Measures; Mental Health; Mental Tests; Modeling; National Institute of Mental Health; Neuropsychological Tests; Neuropsychology; Office Visits; Outcome; Participant; Persons; Population; Preparation; Protocols documentation; Recommendation; Research; Research Personnel; Resources; Respondent; Risk; Sampling; Semantic memory; Short-Term Memory; Standardization; Stimulus; Structure; Subgroup; Testing; Time; Training; Underserved Population; Validation; age related; aged; attentional control; cognitive ability; cognitive function; cognitive performance; cognitive task; cognitive testing; computerized; design; flexibility; improved; innovation; mild cognitive impairment; platform-independent; processing speed; prototype; response; risk stratification; self-directed learning; theories; tool; young adult

Project Abstract With the aging of the American population, the number of older adults at risk for developing cognitive impairment is staggering. Recent research points to age-related change in cognitive performance beginning as early as age 30, highlighting the potential for early interventions. Cognitive function has long been assessed using standardized cognitive tasks administered via neuropsychological evaluation. However, the traditional way to assess cognitive ability is time consuming, requires trained personnel, requires an office visit, and identifying decline among younger adults is particularly challenging because it can be masked by item redundancy effects. Here we propose developing a new computerized adaptive test (CAT) to assess cognitive function, either in clinic or remotely, that is based on recent advances in multidimensional item response theory (MIRT). We are calling it the CAT-COG. The CAT-COG will assess global cognitive ability as a primary domain as well as 5 cognitive subdomains: episodic memory, language/semantic memory, processing speed, attentional control/working memory, flexible cognition/reasoning. Our approach will revolutionize computer-based cognitive testing (ultimately in a platform independent way), providing precise estimation of an individual’s ability on these domains with minimal respondent burden, using a sufficiently large bank of items so that the same individual’s cognitive ability can be assessed repeatedly without reusing items or stimuli. This project brings together an accomplished interdisciplinary team of researchers and also builds on the unique resources of the Rush Alzheimer’s Disease Center (RADC). These are the key project steps: (1) We will develop a new 500 item bank of cognitive tasks and test them alongside a standard battery of neuropsychological tests through the RADC, and in an online Prolific sample that includes younger adults. (2) Based on these data, we will develop a computerized adaptive test (CAT- COG) appropriate for measuring global cognitive function and cognitive subdomains across the life course. (3) We will test and validate the CAT-COG among returning RADC participants who will also receive traditional neuropsychological testing. (4) We will study short-term variability of the CAT-COG based on daily assessment for a week to determine learning effects and develop a testing protocol that is immune to such effects. (5) we will harmonize the CAT-COG with the RADC standard battery of neuropsychological tests so that existing data can be linked to newly collected CAT-COG assessments.

项目摘要 随着美国人口的老龄化，有认知障碍风险的老年人数量 是惊人的。最近的研究指出，认知能力的年龄相关变化早在年龄 30，强调早期干预的潜力。长期以来，认知功能一直是用 通过神经心理学评估管理的标准化认知任务。然而，传统的方法， 评估认知能力是耗时的，需要训练有素的人员，需要办公室访问，并确定 年轻人的下降尤其具有挑战性，因为它可能被项目冗余效应所掩盖。 在这里，我们建议开发一种新的计算机化自适应测试（CAT）来评估认知功能，无论是在 临床或远程，这是基于多维项目反应理论（MIRT）的最新进展。我们 称之为猫-COG。CAT-COG将评估作为主要领域的全球认知能力以及5 认知子领域：情景记忆，语言/语义记忆，处理速度，注意力 控制/工作记忆，灵活认知/推理。我们的方法将彻底改变计算机认知 测试（最终以独立于平台的方式），提供对个人在这些方面的能力的精确估计 域与最小的答复负担，使用足够大的银行的项目，使同一个人的 认知能力可以在不重复使用项目或刺激的情况下重复评估。该项目汇集了一个 完成跨学科的研究人员团队，并建立在拉什的独特资源 阿尔茨海默病中心（RADC）。项目的关键步骤是：（1）建立一个新的500道题库 并通过RADC将其与标准的神经心理学测试组合一起进行测试， 在一个包括年轻人的在线多产样本中。(2)根据这些数据，我们将开发一个 计算机化适应性测试（CAT- COG）适用于测量整体认知功能和认知功能 生命历程中的子领域。(3)我们将在返回的RADC中测试和验证CAT-COG 参与者还将接受传统的神经心理学测试。(4)我们将研究短期的变化， CAT-COG基于一周的日常评估，以确定学习效果并制定测试 该协议对此类影响免疫。(5)我们将协调CAT-COG与RADC标准电池， 神经心理学测试，使现有的数据可以链接到新收集的CAT-COG评估。