Continuation of the NuMoM2b Heart Health Study

NuMoM2b 心脏健康研究的延续

• 批准号: 10905863
• 负责人: Philip Greenland
• 金额: $ 213万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10905863
• 关键词: Address; Ancillary Study; Birth; COVID-19 pandemic effects; Cardiac health; Cardiovascular Diseases; Complex; Data; Data Analyses; Enrollment; Environment; Gestational Diabetes; Hypertension; Incentives; Infrastructure; Investments; Knowledge; Monitor; Mothers; Network Infrastructure; Nulliparity; Outcome Study; Participant; Persons; Phase; Pilot Projects; Positioning Attribute; Pregnancy; Pregnancy Outcome; Premature Birth; Recontacts; Reporting; Research; Research Personnel; Resources; Risk Factors; Running; Site; Small for Gestational Age Infant; Surveys; Time; Travel; Visit; Woman; Work; adverse pregnancy outcome; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cohort; follow-up; improved; maternal outcome; patient engagement; phenotypic data; post-pandemic; pregnancy disorder; remote visit; research study; resilience; support network

Project Summary/Abstract Adverse pregnancy outcomes (APO), including hypertensive disorders of pregnancy, preterm birth, small for gestational age birth, and gestational diabetes, are associated with cardiovascular disease (CVD) risk in mothers. The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be (nuMoM2b) collected biospecimens during pregnancy and extensive phenotyping data for 10,038 nulliparous women from 2010-13. The nuMoM2b Heart Health Study is comprised of 7,003 nuMoM2b participants who were recontacted at least once after their nuMoM2b birth, 4,508 of whom returned for an in-person CVD risk factor assessment 2-7 years later. This cohort is currently in a second phase of followup, with multiple ancillary studies running in parallel, and is uniquely positioned to address questions about the complex interplay of APOs and maternal CVD. Unfortunately, the network is facing several challenges related to the downstream effects of the COVID-19 pandemic. We propose four activities to address these challenges, improve participant engagement, and expand the network infrastructure: • Increasing participant incentives. Prior increases in incentives have resulted in improved rates of survey completion. We plan an additional increase, reflecting the significant time investment and commitment of our study participants. • Increasing study network support. Downstream effects of the COVID-19 pandemic include reduced participant engagement with research studies and increased rates of missed study visits, which increase the time required to complete planned activities. Increasing the level of support to network sites will improve their ability to respond to these challenges and build network resilience. • Implementing a pilot study of remote visits. Since the original time of enrollment in nuMoM2b, about 30% of study participants have moved away from their network sites and are no longer located within a travel distance that allows them to attend in-person study visits. We propose to complete a pilot study of remote visits using a national network of mobile phlebotomists to evaluate remote visits as a strategic approach to maintaining engagement of these participants. • Sustaining infrastructure. To further improve participant engagement, the network will convene a Participant Engagement Committee and expand its online informational content. In addition, analytic support to network investigators will be expanded and recently collected data will be prepared for release to support timely reporting of results.

项目总结/摘要 不良妊娠结局（APO），包括妊娠期高血压疾病、早产 出生、小于胎龄儿出生和妊娠期糖尿病， 心血管疾病（CVD）的风险在母亲。未产妊娠结局研究： 监测孕妇在怀孕期间收集的生物标本（nuMoM 2b）， 2010- 2013年10，038名未生育妇女的表型数据。nuMoM 2b心脏健康 研究由7，003名nuMoM 2b参与者组成，这些参与者在治疗后至少重新联系过一次 他们的nuMoM 2b出生，其中4，508人返回进行面对面CVD风险因素评估2-7 年后该队列目前处于第二阶段的随访，有多项辅助研究 并行运行，并处于独特的位置，以解决有关复杂的相互作用的问题， 和母亲心血管疾病的风险不幸的是，该网络正面临着与以下方面有关的几个挑战： COVID-19疫情的下游影响。我们建议开展四项活动来解决这些问题 挑战，提高参与者的参与度，并扩展网络基础设施： ·增加参与者激励。先前增加的奖励措施导致改善了 调查完成率。我们计划额外增加，以反映 我们的研究参与者的投资和承诺。 加强学习网络支持。2019冠状病毒病疫情的下游影响 包括减少参与者参与研究，增加 错过研究访视，这增加了完成计划活动所需的时间。 提高对网络站点的支持水平将提高它们对以下问题作出反应的能力： 应对这些挑战，并建立网络弹性。 开展远程访问试点研究。自最初的入组时间起， nuMoM 2b，大约30%的研究参与者已经离开了他们的网络站点 并且不再位于允许他们亲自参加的旅行距离内 研究访问。我们建议利用国家一级的远程访问系统完成一项试点研究。 移动的抽血师网络，以评估远程访问作为一种战略方法， 保持这些参与者的参与。 ·持续的基础设施。为了进一步提高参与者的参与度，该网络将 召集参与者参与委员会，并扩大其在线信息 内容此外，将扩大对网络调查员的分析支助， 最近收集的数据将准备发布，以支持及时报告结果。

项目成果

Association between aspirin use during pregnancy and cardiovascular risk factors 2-7 years after delivery: The nuMoM2b Heart Health Study.

• DOI: 10.1016/j.preghy.2022.01.012
• 发表时间: 2022-06
• 期刊: PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
• 影响因子: 2.2
• 作者: Theilen, Lauren H.;Greenland, Philip;Varagic, Jasmina;Catov, Janet;Shanks, Anthony;Thorsten, Vanessa;Parker, Corette B.;McNeil, Rebecca;Mercer, Brian;Hoffman, Matthew;Wapner, Ronald;Haas, David;Simhan, Hyagriv;Grobman, William;Chung, Judith H.;Levine, Lisa D.;Barnes, Shannon;Merz, Noel Bairey;Saade, George;Silver, Robert M.
• 通讯作者: Silver, Robert M.

Early Pregnancy Atherogenic Profile in a First Pregnancy and Hypertension Risk 2 to 7 Years After Delivery.

• DOI: 10.1161/jaha.120.017216
• 发表时间: 2021-03
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Catov JM;McNeil RB;Marsh DJ;Mercer BM;Bairey Merz CN;Parker CB;Pemberton VL;Saade GR;Chen YI;Chung JH;Ehrenthal DB;Grobman WA;Haas DM;Parry S;Polito L;Reddy UM;Silver RM;Simhan HN;Wapner RJ;Kominiarek M;Kreutz R;Levine LD;Greenland P;NHLBI nuMoM2b Heart Health Study
• 通讯作者: NHLBI nuMoM2b Heart Health Study

Associations of the Neighborhood Built Environment with Gestational Weight Gain.

• DOI: 10.1055/s-0041-1730363
• 发表时间: 2023-04
• 期刊: American journal of perinatology
• 影响因子: 2
• 作者: Grobman WA;Crenshaw EG;Marsh DJ;McNeil RB;Pemberton VL;Haas DM;Debbink M;Mercer BM;Parry S;Reddy U;Saade G;Simhan H;Mukhtar F;Wing DA;Kershaw KN;NICHD nuMoM2b NHLBI nuMoM2b Heart Health Study Networks
• 通讯作者: NICHD nuMoM2b NHLBI nuMoM2b Heart Health Study Networks

Associations of the Neighborhood Built Environment With Physical Activity Across Pregnancy.

• DOI: 10.1123/jpah.2020-0510
• 发表时间: 2021-05-01
• 期刊: Journal of physical activity & health
• 影响因子: 3.1
• 作者: Kershaw KN;Marsh DJ;Crenshaw EG;McNeil RB;Pemberton VL;Cordon SA;Haas DM;Debbink MP;Mercer BM;Parry S;Reddy U;Saade G;Simhan H;Wapner RJ;Wing DA;Grobman WA;NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study Networks
• 通讯作者: NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study Networks

Serum Cotinine and Adverse Cardiovascular Outcomes: A Cross-sectional Secondary Analysis of the nuMoM2b Heart Health Study.

• DOI: 10.1055/a-1580-3155
• 发表时间: 2023-09
• 期刊: American journal of perinatology
• 影响因子: 2
• 作者: Theilen LH;McNeil RB;Hunter S;Grobman WA;Parker CB;Catov JM;Pemberton VL;Ehrenthal DB;Haas DM;Hoffman MK;Chung JH;Mukhtar F;Arzumanyan Z;Mercer B;Parry S;Saade GR;Simhan HN;Wapner RJ;Silver RM;NHLBI nuMoM2b Heart Health Study Network
• 通讯作者: NHLBI nuMoM2b Heart Health Study Network