Continuation of the NuMoM2b Heart Health Study

NuMoM2b 心脏健康研究的延续

• 批准号: 10905863
• 负责人: Philip Greenland
• 金额: $ 213万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10905863
• 关键词: Address; Ancillary Study; Birth; COVID-19 pandemic effects; Cardiac health; Cardiovascular Diseases; Complex; Data; Data Analyses; Enrollment; Environment; Gestational Diabetes; Hypertension; Incentives; Infrastructure; Investments; Knowledge; Monitor; Mothers; Network Infrastructure; Nulliparity; Outcome Study; Participant; Persons; Phase; Pilot Projects; Positioning Attribute; Pregnancy; Pregnancy Outcome; Premature Birth; Recontacts; Reporting; Research; Research Personnel; Resources; Risk Factors; Running; Site; Small for Gestational Age Infant; Surveys; Time; Travel; Visit; Woman; Work; adverse pregnancy outcome; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cohort; follow-up; improved; maternal outcome; patient engagement; phenotypic data; post-pandemic; pregnancy disorder; remote visit; research study; resilience; support network

Project Summary/Abstract Adverse pregnancy outcomes (APO), including hypertensive disorders of pregnancy, preterm birth, small for gestational age birth, and gestational diabetes, are associated with cardiovascular disease (CVD) risk in mothers. The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be (nuMoM2b) collected biospecimens during pregnancy and extensive phenotyping data for 10,038 nulliparous women from 2010-13. The nuMoM2b Heart Health Study is comprised of 7,003 nuMoM2b participants who were recontacted at least once after their nuMoM2b birth, 4,508 of whom returned for an in-person CVD risk factor assessment 2-7 years later. This cohort is currently in a second phase of followup, with multiple ancillary studies running in parallel, and is uniquely positioned to address questions about the complex interplay of APOs and maternal CVD. Unfortunately, the network is facing several challenges related to the downstream effects of the COVID-19 pandemic. We propose four activities to address these challenges, improve participant engagement, and expand the network infrastructure: • Increasing participant incentives. Prior increases in incentives have resulted in improved rates of survey completion. We plan an additional increase, reflecting the significant time investment and commitment of our study participants. • Increasing study network support. Downstream effects of the COVID-19 pandemic include reduced participant engagement with research studies and increased rates of missed study visits, which increase the time required to complete planned activities. Increasing the level of support to network sites will improve their ability to respond to these challenges and build network resilience. • Implementing a pilot study of remote visits. Since the original time of enrollment in nuMoM2b, about 30% of study participants have moved away from their network sites and are no longer located within a travel distance that allows them to attend in-person study visits. We propose to complete a pilot study of remote visits using a national network of mobile phlebotomists to evaluate remote visits as a strategic approach to maintaining engagement of these participants. • Sustaining infrastructure. To further improve participant engagement, the network will convene a Participant Engagement Committee and expand its online informational content. In addition, analytic support to network investigators will be expanded and recently collected data will be prepared for release to support timely reporting of results.

项目概要/摘要 不良妊娠结局 (APO)，包括妊娠高血压疾病、早产 出生、小于胎龄出生和妊娠期糖尿病与 母亲患心血管疾病（CVD）的风险。未产儿妊娠结局研究： 准妈妈监测 (nuMoM2b) 在怀孕期间和广泛收集生物样本 2010-13 年 10,038 名未生育女性的表型数据。 nuMoM2b 心脏健康 研究由 7,003 名 nuMoM2b 参与者组成，他们在研究后至少重新联系过一次 他们的 nuMoM2b 出生，其中 4,508 人返回进行面对面的 CVD 危险因素评估 2-7 几年后。该队列目前正处于随访的第二阶段，有多项辅助研究 并行运行，并且具有独特的定位来解决有关复杂相互作用的问题 APO 和母亲 CVD 的关系。不幸的是，该网络面临着一些与以下方面相关的挑战： COVID-19 大流行的下游影响。我们提出四项活动来解决这些问题 挑战、提高参与者参与度并扩展网络基础设施： • 增加参与者的激励。先前增加的激励措施已导致改善 调查完成率。我们计划额外增加，以反映重要的时间 我们的研究参与者的投资和承诺。 • 增加学习网络支持。 COVID-19 大流行的下游影响 包括减少参与者对研究的参与以及增加的比率 错过考察访问，这会增加完成计划活动所需的时间。 提高对网站的支持水平将提高他们的响应能力 这些挑战并建立网络弹性。 • 实施远程访问试点研究。自原定入学时间起 nuMoM2b，大约 30% 的研究参与者已经离开他们的网站 并且不再位于允许他们亲自参加的旅行距离内 考察访问。我们建议利用国家标准完成远程访问试点研究 移动抽血医生网络评估远程访问作为一种战略方法 保持这些参与者的参与。 • 维持基础设施。为了进一步提高参与者的参与度，该网络将 召集参与者参与委员会并扩大其在线信息 内容。此外，还将扩大对网络调查人员的分析支持， 最近收集的数据将准备发布，以支持及时报告结果。

项目成果

Association between aspirin use during pregnancy and cardiovascular risk factors 2-7 years after delivery: The nuMoM2b Heart Health Study.

• DOI: 10.1016/j.preghy.2022.01.012
• 发表时间: 2022-06
• 期刊: PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
• 影响因子: 2.2
• 作者: Theilen, Lauren H.;Greenland, Philip;Varagic, Jasmina;Catov, Janet;Shanks, Anthony;Thorsten, Vanessa;Parker, Corette B.;McNeil, Rebecca;Mercer, Brian;Hoffman, Matthew;Wapner, Ronald;Haas, David;Simhan, Hyagriv;Grobman, William;Chung, Judith H.;Levine, Lisa D.;Barnes, Shannon;Merz, Noel Bairey;Saade, George;Silver, Robert M.
• 通讯作者: Silver, Robert M.

Early Pregnancy Atherogenic Profile in a First Pregnancy and Hypertension Risk 2 to 7 Years After Delivery.

• DOI: 10.1161/jaha.120.017216
• 发表时间: 2021-03
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Catov JM;McNeil RB;Marsh DJ;Mercer BM;Bairey Merz CN;Parker CB;Pemberton VL;Saade GR;Chen YI;Chung JH;Ehrenthal DB;Grobman WA;Haas DM;Parry S;Polito L;Reddy UM;Silver RM;Simhan HN;Wapner RJ;Kominiarek M;Kreutz R;Levine LD;Greenland P;NHLBI nuMoM2b Heart Health Study
• 通讯作者: NHLBI nuMoM2b Heart Health Study

Associations of the Neighborhood Built Environment with Gestational Weight Gain.

• DOI: 10.1055/s-0041-1730363
• 发表时间: 2023-04
• 期刊: American journal of perinatology
• 影响因子: 2
• 作者: Grobman WA;Crenshaw EG;Marsh DJ;McNeil RB;Pemberton VL;Haas DM;Debbink M;Mercer BM;Parry S;Reddy U;Saade G;Simhan H;Mukhtar F;Wing DA;Kershaw KN;NICHD nuMoM2b NHLBI nuMoM2b Heart Health Study Networks
• 通讯作者: NICHD nuMoM2b NHLBI nuMoM2b Heart Health Study Networks

Associations of the Neighborhood Built Environment With Physical Activity Across Pregnancy.

• DOI: 10.1123/jpah.2020-0510
• 发表时间: 2021-05-01
• 期刊: Journal of physical activity & health
• 影响因子: 3.1
• 作者: Kershaw KN;Marsh DJ;Crenshaw EG;McNeil RB;Pemberton VL;Cordon SA;Haas DM;Debbink MP;Mercer BM;Parry S;Reddy U;Saade G;Simhan H;Wapner RJ;Wing DA;Grobman WA;NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study Networks
• 通讯作者: NICHD nuMoM2b and NHLBI nuMoM2b Heart Health Study Networks

Serum Cotinine and Adverse Cardiovascular Outcomes: A Cross-sectional Secondary Analysis of the nuMoM2b Heart Health Study.

• DOI: 10.1055/a-1580-3155
• 发表时间: 2023-09
• 期刊: American journal of perinatology
• 影响因子: 2
• 作者: Theilen LH;McNeil RB;Hunter S;Grobman WA;Parker CB;Catov JM;Pemberton VL;Ehrenthal DB;Haas DM;Hoffman MK;Chung JH;Mukhtar F;Arzumanyan Z;Mercer B;Parry S;Saade GR;Simhan HN;Wapner RJ;Silver RM;NHLBI nuMoM2b Heart Health Study Network
• 通讯作者: NHLBI nuMoM2b Heart Health Study Network