Continuation of the NuMoM2b Heart Health Study

NuMoM2b 心脏健康研究的延续

• 批准号: 10657212
• 负责人: Philip Greenland
• 金额: $ 28.17万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657212
• 关键词: Address; Aliquot; Cardiac health; DNA; Data; Data Aggregation; Enrollment; Ensure; Equipment and supply inventories; Fetal Growth Retardation; Foundations; Funding; Gestational Diabetes; Health; Hypertension; Infrastructure; Knowledge; Leadership; Learning; Metadata; Monitor; Mothers; National Institute of Child Health and Human Development; Nulliparity; Outcome; Outcome Study; Persons; Phenotype; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Premature Birth; Prevention strategy; Process; Quality Control; Research; Research Personnel; Resource Sharing; Risk; Risk Factors; Running; Specific qualifier value; Specimen; Update; Woman; Work; adverse pregnancy outcome; cohort; fetal; pregnant; risk prediction

PROJECT SUMMARY/ABSTRACT Adverse pregnancy outcomes and complications such as preterm birth, preeclampsia, intrauterine growth restriction, and gestational diabetes present significant risks to pregnant people. The strongest predictor of these pregnancy outcomes is the occurrence of the outcome during a prior pregnancy; however, this leaves a large knowledge gap regarding risk prediction for people in their first pregnancy (nulliparas). To address this gap, the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) enrolled and richly phenotyped a demographically diverse cohort of women during their first pregnancy. The cohort’s high-quality data and biospecimens were collected under regulatory frameworks that support resource sharing and data compilation leading to use in future research. The upcoming public release of nuMoM2b biospecimens requires the aggregation of biospecimen metadata using a templated spreadsheet provided by NICHD, which will be completed by the nuMoM2b Heart Health Study team at RTI. The data provided to NICHD will include all requested fields available in the project data. These data will be provided for the biospecimens that were originally collected during nuMoM2b and have not yet been analyzed or earmarked for analysis and a set of aliquots of maternal and fetal DNA that were derived from nuMoM2b specimens. The Specific Aims reflect an efficient approach to completing advantageous biospecimen compilation, which can be used in analyses going forward. The RTI team will receive updated biospecimen inventories from the network partners tracking nuMoM2b biospecimen use (Aim 1). Once RTI receives information, the nuMoM2b Heart Health Study team will run quality control checks against the inventory files to ensure accuracy of information and then merge them with the nuMoM2b data (Aim 2). Upon merging, data will then be exported in the available biospecimen metadata fields in the requested format (Aim 3). Throughout the process, the team will also provide support for administration of the funds to support this work. With a foundation of strong leadership and technical infrastructure, RTI will provide an ideal setting for compiling nuMoM2b data to continue addressing critical knowledge gaps in the field.

项目概要/摘要 不良妊娠结局和并发症，如早产、先兆子痫、 宫内生长受限和妊娠糖尿病给孕妇带来重大风险。 这些妊娠结局的最强预测因素是妊娠期间结果的发生 怀孕前；然而，这给人们在风险预测方面留下了巨大的知识空白 他们的第一次怀孕（nulliparas）。为了解决这一差距，未产儿妊娠结局研究： 监测准妈妈 (nuMoM2b) 已登记并具有人口多样化的丰富表型 第一次怀孕期间的妇女群体。该队列的高质量数据和生物样本是 在支持资源共享和数据汇编领先的监管框架下收集 用于未来的研究。即将公开发布的 nuMoM2b 生物样本需要 使用 NICHD 提供的模板电子表格聚合生物样本元数据， 将由 RTI 的 nuMoM2b 心脏健康研究团队完成。向 NICHD 提供的数据 将包括项目数据中可用的所有请求字段。这些数据将提供给 最初在 nuMoM2b 期间收集且尚未分析的生物样本，或 指定用于分析的一组母体和胎儿 DNA 等份，源自 nuMoM2b 标本。具体目标反映了完成有利目标的有效方法 生物样本编译，可用于后续分析。 RTI 团队将收到 跟踪 nuMoM2b 生物样本使用的网络合作伙伴更新的生物样本库存 （目标 1）。一旦 RTI 收到信息，nuMoM2b 心脏健康研究团队将进行质量评估 控制检查库存文件以确保信息的准确性，然后合并它们 与 nuMoM2b 数据（目标 2）。合并后，数据将导出到可用的 生物样本元数据字段采用所请求的格式（目标 3）。在整个过程中，团队将 还为支持这项工作的资金管理提供支持。凭借雄厚的基础 RTI 的领导力和技术基础设施将为编译 nuMoM2b 提供理想的环境 数据以继续解决该领域的关键知识差距。