Continuation of the NuMoM2b Heart Health Study

NuMoM2b 心脏健康研究的延续

• 批准号: 10657212
• 负责人: Philip Greenland
• 金额: $ 28.17万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657212
• 关键词: Address; Aliquot; Cardiac health; DNA; Data; Data Aggregation; Enrollment; Ensure; Equipment and supply inventories; Fetal Growth Retardation; Foundations; Funding; Gestational Diabetes; Health; Hypertension; Infrastructure; Knowledge; Leadership; Learning; Metadata; Monitor; Mothers; National Institute of Child Health and Human Development; Nulliparity; Outcome; Outcome Study; Persons; Phenotype; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Premature Birth; Prevention strategy; Process; Quality Control; Research; Research Personnel; Resource Sharing; Risk; Risk Factors; Running; Specific qualifier value; Specimen; Update; Woman; Work; adverse pregnancy outcome; cohort; fetal; pregnant; risk prediction

PROJECT SUMMARY/ABSTRACT Adverse pregnancy outcomes and complications such as preterm birth, preeclampsia, intrauterine growth restriction, and gestational diabetes present significant risks to pregnant people. The strongest predictor of these pregnancy outcomes is the occurrence of the outcome during a prior pregnancy; however, this leaves a large knowledge gap regarding risk prediction for people in their first pregnancy (nulliparas). To address this gap, the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) enrolled and richly phenotyped a demographically diverse cohort of women during their first pregnancy. The cohort’s high-quality data and biospecimens were collected under regulatory frameworks that support resource sharing and data compilation leading to use in future research. The upcoming public release of nuMoM2b biospecimens requires the aggregation of biospecimen metadata using a templated spreadsheet provided by NICHD, which will be completed by the nuMoM2b Heart Health Study team at RTI. The data provided to NICHD will include all requested fields available in the project data. These data will be provided for the biospecimens that were originally collected during nuMoM2b and have not yet been analyzed or earmarked for analysis and a set of aliquots of maternal and fetal DNA that were derived from nuMoM2b specimens. The Specific Aims reflect an efficient approach to completing advantageous biospecimen compilation, which can be used in analyses going forward. The RTI team will receive updated biospecimen inventories from the network partners tracking nuMoM2b biospecimen use (Aim 1). Once RTI receives information, the nuMoM2b Heart Health Study team will run quality control checks against the inventory files to ensure accuracy of information and then merge them with the nuMoM2b data (Aim 2). Upon merging, data will then be exported in the available biospecimen metadata fields in the requested format (Aim 3). Throughout the process, the team will also provide support for administration of the funds to support this work. With a foundation of strong leadership and technical infrastructure, RTI will provide an ideal setting for compiling nuMoM2b data to continue addressing critical knowledge gaps in the field.

项目摘要/摘要 不良妊娠结局和并发症，例如早产，先兆子痫， 内氨酸内生长限制和妊娠糖尿病对孕妇带来了重大风险。 这些妊娠结局的强有力预测指标是结果在 先前怀孕；但是，这给人们留下了很大的知识差距 他们的第一次怀孕（零帕拉斯）。为了解决这一差距，无效的妊娠结局研究： 监控准母亲（NUMOM2B）已注册并表现出丰富的人口统计学多样 妇女在第一次怀孕期间。队列的高质量数据和生物测量是 在支持资源共享和数据汇编领先的监管框架下收集 用于未来的研究。 NUMOM2B生物测量的即将发布的公开发布需要 使用NICHD提供的模板电子表格的生物测试元数据的聚合， RTI的NUMOM2B心脏健康研究团队将完成。提供给NICHD的数据 将包括项目数据中可用的所有请求字段。这些数据将用于 最初在NUMOM2B期间收集但尚未分析或 专门用于分析以及一组来自的母体和胎儿DNA的等分试样 NUMOM2B标本。具体目的反映了一种有效的方法来完成有利的方法 生物测量汇编，可用于分析。 RTI团队将收到 来自网络合作伙伴的更新生物循环库存跟踪NUMOM2B BiosseCimen使用 （目标1）。 RTI收到信息后，Numom2B心脏健康研究团队将运行质量 控制检查库存文件以确保信息的准确性，然后将其合并 使用NUMOM2B数据（AIM 2）。合并后，数据将在可用的 以请求格式的生物测膜元数据（AIM 3）。通过整个过程，团队将 还为管理资金提供支持以支持这项工作。有坚强的基础 领导力和技术基础设施，RTI将为编译NUMOM2B提供理想的环境 数据继续解决该领域的关键知识差距。