Continuation of the NuMoM2b Heart Health Study

NuMoM2b 心脏健康研究的延续

• 批准号: 10200499
• 负责人: Philip Greenland
• 金额: $ 238.96万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10200499
• 关键词: Address; Age; Ancillary Study; Behavioral; Biometry; Birth; Cardiac health; Cardiology; Cardiovascular Diseases; Cardiovascular system; Cerebrovascular Disorders; Cessation of life; Clinical; Clinical Data; Cohort Studies; Data; Data Collection; Development; Diabetes Mellitus; Enrollment; Environment; Foundations; Future; Geography; Gestational Diabetes; Goals; Grant; Hypertension; Incidence; Incidence Study; Infrastructure; Investigation; Kidney Diseases; Knowledge; Leadership; Link; Maternal-fetal medicine; Mediating; Metabolic syndrome; Morbidity - disease rate; Obesity; Observational Study; Participant; Pattern; Persons; Phenotype; Physical activity; Pregnancy; Premature Birth; Prevention; Prevention strategy; Process; Recurrence; Resource Sharing; Resources; Risk Factors; Schedule; Scientist; Sleep Apnea Syndromes; Small for Gestational Age Infant; Smoking; Structure; Time; United States; United States National Institutes of Health; Vision; Visit; Woman; adverse pregnancy outcome; cardiovascular disorder risk; cohort; ethnic diversity; experience; follow-up; indexing; infrastructure development; mortality; multimodality; nutrition; pregnancy hypertension; prospective; reproductive; stillbirth; success; treatment strategy

PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and large knowledge gaps exist in CVD predictive and preventive strategies for women. The nuMoM2b Heart Health Study (nuMoM2b-HHS) has followed a demographically diverse cohort of 4,475 women enrolled and richly phenotyped during their first pregnancy, with data and biospecimens prospectively collected for up to 7 years thereafter. The overarching scientific goal of the nuMoM2b-HHS is to define the relationship between adverse pregnancy outcomes (APOs) and CVD to optimize CVD prediction, prevention, and treatment strategies for women. Continued follow-up of this cohort, building on a foundation of existing high-quality data, biospecimens, and administrative structures with a robust framework for ancillary study development and implementation, provides a unique opportunity to address knowledge gaps regarding the early mechanisms and trajectory of CVD in women. We propose to continue nuMoM2b-HHS follow-up through semiannual contacts and an in-person visit to assess CVD risk factors during grant years 3-5 (Aim 1). Accumulated longitudinal data and biospecimens will serve as a broadly accessible platform for ancillary studies to identify early mechanisms of CVD and to address additional NIH priority domains including early manifestations of cerebrovascular and renal disease in reproductive-age women. Ancillary studies (Aim 2) will expand data collection during the follow-up contacts and in-person visit, and add to the planned contact schedule, to permit the effective targeting of knowledge gaps required to optimize predictive and preventive strategies. The Specific Aims reflect a multifaceted approach to the study of the incidence and mechanisms of CVD development in women of reproductive age, focusing on the incidence of CVD risk factors in women with and without APOs (Aim 3); the associations between atherogenic phenotypes and sleep-disordered breathing during and after pregnancy and estimated CVD risk 6-15 years later (Aims 4 and 5, respectively); and identification of modifiable factors that influence or moderate these associations (Aim 6). This application has several strengths that reflect the potential for long-term success of the cohort: (1) The nuMoM2b-HHS will be led by three deeply experienced PIs with complementary domains of expertise in cardiology, maternal-fetal medicine, and biostatistics. (2) The network has robust infrastructure in place to maintain long-term participant engagement and support rigorous data collection. (3) The cohort's high-quality data and biospecimens have been collected under regulatory frameworks that support resource sharing and use in future research. (4) The network has established processes for successfully proposing, reviewing, and implementing ancillary studies. This foundation of strong leadership, robust administrative and operational infrastructure, and actualized long-term vision will provide an ideal environment for the nuMoM2b-HHS to continue to address critical knowledge gaps concerning CVD development in women of reproductive age.

项目摘要/摘要 心血管疾病（CVD）是各个年龄段的美国妇女死亡率和发病率的主要原因， CVD预测性和预防性策略中存在较大的知识差距。 numom2b心 健康研究（NUMOM2B-HHS）遵循了4,475名女性的人口统计学群体， 在第一次怀孕期间，表现出丰富的表型，数据和生物测量的前瞻性收集到7个 此后几年。 NUMOM2B-HHS的总体科学目标是定义 不良怀孕结果（APO）和CVD，以优化CVD预测，预防和治疗 妇女的策略。继续跟进这个队列，建立在现有高质量的基础上 具有辅助研究开发框架的数据，生物测量和行政结构 和实施，提供了一个独特的机会来解决有关早期知识的差距 女性CVD的机制和轨迹。我们建议通过Numom2B-HHS随访 半年度接触和面对面访问，以评估3 - 5年期间的CVD风险因素（AIM 1）。 累积的纵向数据和生物测量将成为辅助的广泛访问平台 研究以识别CVD的早期机制，并解决其他NIH优先级领域，包括早期 生殖时代妇女中脑血管和肾脏疾病的表现。辅助研究（目标2） 将在后续联系和面对面访问期间扩展数据收集，并添加到计划中的联系人 时间表，允许有效靶向优化预测性和预防性所需的知识差距 策略。具体目的反映了一种多方面研究的方法和机制的方法 生殖年龄妇女的CVD发展，重点是女性CVD风险因素的发生率 有和没有APO（AIM 3）；动脉粥样硬化表型与睡眠状态之间的关联 怀孕期间和呼吸呼吸和估计的CVD风险在6 - 15年后（分别为4和5）； 并识别影响或减轻这些关联的可修改因素（AIM 6）。 该应用具有多种优势，反映了队列长期成功的潜力：（1） NUMOM2B-HHS将由三个经验丰富的PI领导，并具有互补的专业知识领域 心脏病学，母亲医学和生物统计学。 （2）该网络具有强大的基础架构 保持长期参与者的参与并支持严格的数据收集。 （3）队列的高质量 数据和生物测量已在支持资源共享和的监管框架下收集 在未来的研究中使用。 （4）该网络已经建立了成功提议，审查和 实施辅助研究。这是强大的领导，强大的行政和运营的基础 基础架构和实现的长期视觉将为NUMOM2B-HHS提供理想的环境 继续解决有关生殖年龄妇女CVD发展的关键知识差距。